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• W2014746738 abstract "The present study compared the anxiolytic effects of the benzodiazepine agonist diazepam and ethanol in adult male and female rats. Varying doses of diazepam (1–3 mg/kg) or ethanol (0.5–2.0 g/kg) were tested using both the elevated plus maze and defensive prod-burying models. Two time points following ethanol administration (10 and 30 min) were tested in the plus maze. Sex differences were seen in some anxiety-related behaviors, with females showing greater open arm time and reduced burying behavior than males. Although this suggests females displayed less anxiety-like behavior than males, the differences in the plus maze were not observed in all testing situations. Both diazepam and ethanol dose-dependently increased open arm times in the plus maze and reduced burying behavior in the defensive prod-burying task. The parallel nature of the dose–response curves suggests that both diazepam and ethanol have similar anxiolytic effects in males and females. No sex differences were seen in the brain levels of diazepam-like activity or blood alcohol levels with these treatments. A greater corticosterone response was observed in females than males with these two behavioral tests, but neither diazepam nor ethanol decreased this response. These results suggest a dissociation between the anxiety-reducing influences of these compounds and the changes in stress-related endocrine responses." @default.
• W2014746738 created "2016-06-24" @default.
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• W2014746738 creator A5025839314 @default.
• W2014746738 date "2004-07-01" @default.
• W2014746738 modified "2023-10-16" @default.
• W2014746738 title "Anxiolytic effects of diazepam and ethanol in two behavioral models: comparison of males and females" @default.
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• W2014746738 doi "https://doi.org/10.1016/j.pbb.2004.04.017" @default.
• W2014746738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15251253" @default.
• W2014746738 hasPublicationYear "2004" @default.
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