Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014748872> ?p ?o ?g. }
- W2014748872 endingPage "1926" @default.
- W2014748872 startingPage "1923" @default.
- W2014748872 abstract "Mutations in APC or beta-catenin inappropriately activate the transcription factor Tcf4, thereby transforming intestinal epithelial cells. Here it is shown that one of the target genes of Tcf4 in epithelial cells is Tcf1. The most abundant Tcf1 isoforms lack a beta-catenin interaction domain. Tcf1(-/-) mice develop adenomas in the gut and mammary glands. Introduction of a mutant APC allele into these mice substantially increases the number of these adenomas. Tcf1 may act as a feedback repressor of beta-catenin-Tcf4 target genes and thus may cooperate with APC to suppress malignant transformation of epithelial cells." @default.
- W2014748872 created "2016-06-24" @default.
- W2014748872 creator A5032142984 @default.
- W2014748872 creator A5032618320 @default.
- W2014748872 creator A5033586033 @default.
- W2014748872 creator A5036202367 @default.
- W2014748872 creator A5057097524 @default.
- W2014748872 creator A5062248785 @default.
- W2014748872 creator A5071373742 @default.
- W2014748872 creator A5085208309 @default.
- W2014748872 date "1999-09-17" @default.
- W2014748872 modified "2023-10-12" @default.
- W2014748872 title "Synergy Between Tumor Suppressor<i>APC</i>and the β-Catenin-Tcf4 Target<i>Tcf1</i>" @default.
- W2014748872 cites W1484268538 @default.
- W2014748872 cites W1511545125 @default.
- W2014748872 cites W1544046482 @default.
- W2014748872 cites W1554815317 @default.
- W2014748872 cites W1587560668 @default.
- W2014748872 cites W1922040470 @default.
- W2014748872 cites W1958512987 @default.
- W2014748872 cites W1966121721 @default.
- W2014748872 cites W1967137553 @default.
- W2014748872 cites W1975781876 @default.
- W2014748872 cites W1975853332 @default.
- W2014748872 cites W1975993620 @default.
- W2014748872 cites W1979618971 @default.
- W2014748872 cites W1989215255 @default.
- W2014748872 cites W1990606472 @default.
- W2014748872 cites W1999582446 @default.
- W2014748872 cites W2002404925 @default.
- W2014748872 cites W2005958249 @default.
- W2014748872 cites W2033618020 @default.
- W2014748872 cites W2034351801 @default.
- W2014748872 cites W2036864436 @default.
- W2014748872 cites W2039248606 @default.
- W2014748872 cites W2051328757 @default.
- W2014748872 cites W2053666128 @default.
- W2014748872 cites W2056017251 @default.
- W2014748872 cites W2057830803 @default.
- W2014748872 cites W2078591745 @default.
- W2014748872 cites W2081758458 @default.
- W2014748872 cites W2081985759 @default.
- W2014748872 cites W2088681495 @default.
- W2014748872 cites W2090636859 @default.
- W2014748872 cites W2092261702 @default.
- W2014748872 cites W2097098623 @default.
- W2014748872 cites W2098588381 @default.
- W2014748872 cites W2100070586 @default.
- W2014748872 cites W2103345757 @default.
- W2014748872 cites W2129713447 @default.
- W2014748872 cites W2132475598 @default.
- W2014748872 cites W2142522741 @default.
- W2014748872 cites W2146167376 @default.
- W2014748872 cites W2165781463 @default.
- W2014748872 cites W2170839692 @default.
- W2014748872 cites W2171080110 @default.
- W2014748872 doi "https://doi.org/10.1126/science.285.5435.1923" @default.
- W2014748872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10489374" @default.
- W2014748872 hasPublicationYear "1999" @default.
- W2014748872 type Work @default.
- W2014748872 sameAs 2014748872 @default.
- W2014748872 citedByCount "439" @default.
- W2014748872 countsByYear W20147488722012 @default.
- W2014748872 countsByYear W20147488722013 @default.
- W2014748872 countsByYear W20147488722014 @default.
- W2014748872 countsByYear W20147488722015 @default.
- W2014748872 countsByYear W20147488722016 @default.
- W2014748872 countsByYear W20147488722017 @default.
- W2014748872 countsByYear W20147488722018 @default.
- W2014748872 countsByYear W20147488722019 @default.
- W2014748872 countsByYear W20147488722020 @default.
- W2014748872 countsByYear W20147488722021 @default.
- W2014748872 countsByYear W20147488722022 @default.
- W2014748872 countsByYear W20147488722023 @default.
- W2014748872 crossrefType "journal-article" @default.
- W2014748872 hasAuthorship W2014748872A5032142984 @default.
- W2014748872 hasAuthorship W2014748872A5032618320 @default.
- W2014748872 hasAuthorship W2014748872A5033586033 @default.
- W2014748872 hasAuthorship W2014748872A5036202367 @default.
- W2014748872 hasAuthorship W2014748872A5057097524 @default.
- W2014748872 hasAuthorship W2014748872A5062248785 @default.
- W2014748872 hasAuthorship W2014748872A5071373742 @default.
- W2014748872 hasAuthorship W2014748872A5085208309 @default.
- W2014748872 hasConcept C104317684 @default.
- W2014748872 hasConcept C111936080 @default.
- W2014748872 hasConcept C121608353 @default.
- W2014748872 hasConcept C137620995 @default.
- W2014748872 hasConcept C158448853 @default.
- W2014748872 hasConcept C179185449 @default.
- W2014748872 hasConcept C2778237340 @default.
- W2014748872 hasConcept C2779324961 @default.
- W2014748872 hasConcept C30145163 @default.
- W2014748872 hasConcept C502942594 @default.
- W2014748872 hasConcept C526805850 @default.
- W2014748872 hasConcept C53345823 @default.
- W2014748872 hasConcept C54355233 @default.
- W2014748872 hasConcept C86339819 @default.
- W2014748872 hasConcept C86803240 @default.