Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014750311> ?p ?o ?g. }
- W2014750311 endingPage "e116048" @default.
- W2014750311 startingPage "e116048" @default.
- W2014750311 abstract "Activating transcription factor 2 (ATF2) and its homolog ATF7 are phosphorylated at Thr-69/Thr-71 and at Thr-51/Thr-53, respectively, by stress-activated MAPKs regulating their transcriptional functions in G1 and S phases. However, little is known about the role of ATF2 and ATF7 in G2/M phase. Here, we show that Cdk1-cyclin B1 phosphorylates ATF2 at Thr-69/Thr-71 and ATF7 at Thr-51/Thr-53 from early prophase to anaphase in the absence of any stress stimulation. Knockdown of ATF2 or ATF7 decreases the rate of cell proliferation and the number of cells in M-phase. In particular, the knockdown of ATF7 severely inhibits cell proliferation and G2/M progression. The inducible expression of a mitotically nonphosphorylatable version of ATF7 inhibits G2/M progression despite the presence of endogenous ATF7. We also show that mitotic phosphorylation of ATF7 promotes the activation of Aurora kinases, which are key enzymes for early mitotic events. These results suggest that the Cdk1-mediated phosphorylation of ATF7 facilitates G2/M progression, at least in part, by enabling Aurora signaling." @default.
- W2014750311 created "2016-06-24" @default.
- W2014750311 creator A5000998202 @default.
- W2014750311 creator A5002376604 @default.
- W2014750311 creator A5009789102 @default.
- W2014750311 creator A5012464666 @default.
- W2014750311 creator A5013617571 @default.
- W2014750311 creator A5019397425 @default.
- W2014750311 creator A5043689859 @default.
- W2014750311 creator A5050850627 @default.
- W2014750311 creator A5053985691 @default.
- W2014750311 creator A5076149190 @default.
- W2014750311 date "2014-12-29" @default.
- W2014750311 modified "2023-09-27" @default.
- W2014750311 title "Cdk1-Mediated Phosphorylation of Human ATF7 at Thr-51 and Thr-53 Promotes Cell-Cycle Progression into M Phase" @default.
- W2014750311 cites W1483395792 @default.
- W2014750311 cites W1546924283 @default.
- W2014750311 cites W1550055479 @default.
- W2014750311 cites W1555489233 @default.
- W2014750311 cites W1747895236 @default.
- W2014750311 cites W1749711544 @default.
- W2014750311 cites W1886278373 @default.
- W2014750311 cites W1963821864 @default.
- W2014750311 cites W1974654938 @default.
- W2014750311 cites W1978032395 @default.
- W2014750311 cites W1978318806 @default.
- W2014750311 cites W1979653613 @default.
- W2014750311 cites W1981073960 @default.
- W2014750311 cites W1983434575 @default.
- W2014750311 cites W1984507712 @default.
- W2014750311 cites W1984665850 @default.
- W2014750311 cites W1985338536 @default.
- W2014750311 cites W1986858954 @default.
- W2014750311 cites W2004747143 @default.
- W2014750311 cites W2006113261 @default.
- W2014750311 cites W2013714072 @default.
- W2014750311 cites W2020198339 @default.
- W2014750311 cites W2029581772 @default.
- W2014750311 cites W2033107481 @default.
- W2014750311 cites W2036046756 @default.
- W2014750311 cites W2036367334 @default.
- W2014750311 cites W2036515905 @default.
- W2014750311 cites W2039885364 @default.
- W2014750311 cites W2047441102 @default.
- W2014750311 cites W2049904360 @default.
- W2014750311 cites W2049942953 @default.
- W2014750311 cites W2054887299 @default.
- W2014750311 cites W2057501724 @default.
- W2014750311 cites W2059814855 @default.
- W2014750311 cites W2060387110 @default.
- W2014750311 cites W2061145246 @default.
- W2014750311 cites W2064221650 @default.
- W2014750311 cites W2072319964 @default.
- W2014750311 cites W2074342357 @default.
- W2014750311 cites W2074998509 @default.
- W2014750311 cites W2079961202 @default.
- W2014750311 cites W2081660483 @default.
- W2014750311 cites W2085701634 @default.
- W2014750311 cites W2087009412 @default.
- W2014750311 cites W2095312050 @default.
- W2014750311 cites W2096934884 @default.
- W2014750311 cites W2097195870 @default.
- W2014750311 cites W2101117526 @default.
- W2014750311 cites W2112468983 @default.
- W2014750311 cites W2113067498 @default.
- W2014750311 cites W2125624250 @default.
- W2014750311 cites W2127806545 @default.
- W2014750311 cites W2138331322 @default.
- W2014750311 cites W2144983282 @default.
- W2014750311 cites W2146922843 @default.
- W2014750311 cites W2152470204 @default.
- W2014750311 cites W2156934474 @default.
- W2014750311 cites W2162778916 @default.
- W2014750311 cites W2168836733 @default.
- W2014750311 cites W2168881161 @default.
- W2014750311 cites W2328985298 @default.
- W2014750311 cites W2342346004 @default.
- W2014750311 cites W2417732733 @default.
- W2014750311 cites W4244969507 @default.
- W2014750311 cites W4252261908 @default.
- W2014750311 doi "https://doi.org/10.1371/journal.pone.0116048" @default.
- W2014750311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4278844" @default.
- W2014750311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25545367" @default.
- W2014750311 hasPublicationYear "2014" @default.
- W2014750311 type Work @default.
- W2014750311 sameAs 2014750311 @default.
- W2014750311 citedByCount "16" @default.
- W2014750311 countsByYear W20147503112015 @default.
- W2014750311 countsByYear W20147503112016 @default.
- W2014750311 countsByYear W20147503112017 @default.
- W2014750311 countsByYear W20147503112018 @default.
- W2014750311 countsByYear W20147503112019 @default.
- W2014750311 countsByYear W20147503112020 @default.
- W2014750311 countsByYear W20147503112021 @default.
- W2014750311 countsByYear W20147503112022 @default.
- W2014750311 countsByYear W20147503112023 @default.
- W2014750311 crossrefType "journal-article" @default.
- W2014750311 hasAuthorship W2014750311A5000998202 @default.