FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014750558> ?p ?o ?g. }

• W2014750558 endingPage "18055" @default.
• W2014750558 startingPage "18050" @default.
• W2014750558 abstract "O 6 -alkylG adducts are highly mutagenic due to their capacity to efficiently form O 6 -alkylG:T mispairs during replication, thus triggering G→A transitions. Mutagenesis is largely prevented by repair strategies such as reversal by alkyltransferases or excision by nucleotide excision repair (NER). Moreover, methyl-directed mismatch repair (MMR) is known to trigger sensitivity to methylating agents via a mechanism that involves recognition by MutS of the O 6 -mG:T replication intermediates. We wanted to investigate the mechanism by which MMR controls the genotoxicity of environmentally relevant O 6 -alkylG adducts formed by ethylene oxide and propylene oxide. Recently, the alkyltransferase-like gene ybaZ (eATL) was shown to enhance repair of these slightly larger O 6 -alkylG adducts by NER. We analyzed the toxicity and mutagenesis induced by these O 6 -alkylG adducts using single-adducted plasmid probes. We show that the eATL gene product prevents MMR-mediated attack of the O 6 -alkylG:T replication intermediate for the larger alkyl groups but not for methyl. In vivo data are compatible with the occurrence of repeated cycles of MMR attack of the O 6 -alkylG:T intermediate. In addition, in vitro, the eATL protein efficiently prevents binding of MutS to the O 6 -alkylG:T mispairs formed by the larger alkyl groups but not by methyl. In conclusion, eATL not only enhances the efficiency of repair of these larger adducts by NER, it also shields these adducts from MMR-mediated toxicity." @default.
• W2014750558 created "2016-06-24" @default.
• W2014750558 creator A5024503871 @default.
• W2014750558 creator A5035334632 @default.
• W2014750558 creator A5058213120 @default.
• W2014750558 creator A5063314670 @default.
• W2014750558 creator A5073398421 @default.
• W2014750558 creator A5073569847 @default.
• W2014750558 date "2010-10-04" @default.
• W2014750558 modified "2023-10-08" @default.
• W2014750558 title "Alkyltransferase-like protein (eATL) prevents mismatch repair-mediated toxicity induced by <i>O</i> ⁶ -alkylguanine adducts in <i>Escherichia coli</i>" @default.
• W2014750558 cites W1521823278 @default.
• W2014750558 cites W1692796156 @default.
• W2014750558 cites W181491611 @default.
• W2014750558 cites W1908546530 @default.
• W2014750558 cites W1964517328 @default.
• W2014750558 cites W1971483561 @default.
• W2014750558 cites W1974292630 @default.
• W2014750558 cites W1982110422 @default.
• W2014750558 cites W1983632366 @default.
• W2014750558 cites W1985220169 @default.
• W2014750558 cites W1988745200 @default.
• W2014750558 cites W1991064992 @default.
• W2014750558 cites W1993743046 @default.
• W2014750558 cites W1994701134 @default.
• W2014750558 cites W1996872556 @default.
• W2014750558 cites W2001727506 @default.
• W2014750558 cites W2006400713 @default.
• W2014750558 cites W2017709322 @default.
• W2014750558 cites W2021281024 @default.
• W2014750558 cites W2026195203 @default.
• W2014750558 cites W2037898576 @default.
• W2014750558 cites W2042057331 @default.
• W2014750558 cites W2055213533 @default.
• W2014750558 cites W2061880574 @default.
• W2014750558 cites W2070910548 @default.
• W2014750558 cites W2077407509 @default.
• W2014750558 cites W2081962760 @default.
• W2014750558 cites W2089482729 @default.
• W2014750558 cites W2095590111 @default.
• W2014750558 cites W2104859355 @default.
• W2014750558 cites W2113819554 @default.
• W2014750558 cites W2153980875 @default.
• W2014750558 cites W2156305239 @default.
• W2014750558 cites W2160272420 @default.
• W2014750558 cites W2162991490 @default.
• W2014750558 cites W2163529853 @default.
• W2014750558 cites W2165064967 @default.
• W2014750558 cites W2167893234 @default.
• W2014750558 cites W4232147283 @default.
• W2014750558 doi "https://doi.org/10.1073/pnas.1008635107" @default.
• W2014750558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2964255" @default.
• W2014750558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20921378" @default.
• W2014750558 hasPublicationYear "2010" @default.
• W2014750558 type Work @default.
• W2014750558 sameAs 2014750558 @default.
• W2014750558 citedByCount "19" @default.
• W2014750558 countsByYear W20147505582012 @default.
• W2014750558 countsByYear W20147505582013 @default.
• W2014750558 countsByYear W20147505582014 @default.
• W2014750558 countsByYear W20147505582015 @default.
• W2014750558 countsByYear W20147505582016 @default.
• W2014750558 countsByYear W20147505582017 @default.
• W2014750558 countsByYear W20147505582018 @default.
• W2014750558 countsByYear W20147505582019 @default.
• W2014750558 countsByYear W20147505582020 @default.
• W2014750558 countsByYear W20147505582021 @default.
• W2014750558 countsByYear W20147505582023 @default.
• W2014750558 crossrefType "journal-article" @default.
• W2014750558 hasAuthorship W2014750558A5024503871 @default.
• W2014750558 hasAuthorship W2014750558A5035334632 @default.
• W2014750558 hasAuthorship W2014750558A5058213120 @default.
• W2014750558 hasAuthorship W2014750558A5063314670 @default.
• W2014750558 hasAuthorship W2014750558A5073398421 @default.
• W2014750558 hasAuthorship W2014750558A5073569847 @default.
• W2014750558 hasBestOaLocation W20147505581 @default.
• W2014750558 hasConcept C104317684 @default.
• W2014750558 hasConcept C104451858 @default.
• W2014750558 hasConcept C108204754 @default.
• W2014750558 hasConcept C134935766 @default.
• W2014750558 hasConcept C153911025 @default.
• W2014750558 hasConcept C16318435 @default.
• W2014750558 hasConcept C167975912 @default.
• W2014750558 hasConcept C178790620 @default.
• W2014750558 hasConcept C185592680 @default.
• W2014750558 hasConcept C501734568 @default.
• W2014750558 hasConcept C55493867 @default.
• W2014750558 hasConcept C60748783 @default.
• W2014750558 hasConcept C86803240 @default.
• W2014750558 hasConceptScore W2014750558C104317684 @default.
• W2014750558 hasConceptScore W2014750558C104451858 @default.
• W2014750558 hasConceptScore W2014750558C108204754 @default.
• W2014750558 hasConceptScore W2014750558C134935766 @default.
• W2014750558 hasConceptScore W2014750558C153911025 @default.
• W2014750558 hasConceptScore W2014750558C16318435 @default.
• W2014750558 hasConceptScore W2014750558C167975912 @default.
• W2014750558 hasConceptScore W2014750558C178790620 @default.
• W2014750558 hasConceptScore W2014750558C185592680 @default.

• next