Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014751423> ?p ?o ?g. }
- W2014751423 endingPage "258" @default.
- W2014751423 startingPage "249" @default.
- W2014751423 abstract "Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta superfamily, play a variety of roles during mouse development. BMP type II receptor (BMPR-II) is a type II serine/threonine kinase receptor, which transduces signals for BMPs through heteromeric complexes with type I receptors, including activin receptor-like kinase 2 (ALK2), ALK3/BMPR-IA, and ALK6/BMPR-IB. To elucidate the function of BMPR-II in mammalian development, we generated BMPR-II mutant mice by gene targeting. Homozygous mutant embryos were arrested at the egg cylinder stage and could not be recovered at 9.5 days postcoitum. Histological analysis revealed that homozygous mutant embryos failed to form organized structure and lacked mesoderm. The BMPR-II mutant embryos are morphologically very similar to the ALK3/BMPR-IA mutant embryos, suggesting that BMPR-II is important for transducing BMP signals during early mouse development. Moreover, the epiblast of the BMPR-II mutant embryo exhibited an undifferentiated character, although the expression of tissue-specific genes for the visceral endoderm was essentially normal. Our results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development." @default.
- W2014751423 created "2016-06-24" @default.
- W2014751423 creator A5035885878 @default.
- W2014751423 creator A5036892364 @default.
- W2014751423 creator A5046954073 @default.
- W2014751423 creator A5051004924 @default.
- W2014751423 creator A5051009186 @default.
- W2014751423 creator A5072603506 @default.
- W2014751423 creator A5090298420 @default.
- W2014751423 date "2000-05-01" @default.
- W2014751423 modified "2023-10-17" @default.
- W2014751423 title "BMP Type II Receptor Is Required for Gastrulation and Early Development of Mouse Embryos" @default.
- W2014751423 cites W1530364143 @default.
- W2014751423 cites W1606814949 @default.
- W2014751423 cites W1639188211 @default.
- W2014751423 cites W1663371441 @default.
- W2014751423 cites W1680418198 @default.
- W2014751423 cites W1897118574 @default.
- W2014751423 cites W1901605442 @default.
- W2014751423 cites W1930907473 @default.
- W2014751423 cites W1937940610 @default.
- W2014751423 cites W1964269746 @default.
- W2014751423 cites W1980401378 @default.
- W2014751423 cites W1985411380 @default.
- W2014751423 cites W1986902460 @default.
- W2014751423 cites W1996746494 @default.
- W2014751423 cites W2000991526 @default.
- W2014751423 cites W2011334059 @default.
- W2014751423 cites W2016791091 @default.
- W2014751423 cites W2028854652 @default.
- W2014751423 cites W2030656510 @default.
- W2014751423 cites W2040751992 @default.
- W2014751423 cites W2043653995 @default.
- W2014751423 cites W2045673960 @default.
- W2014751423 cites W2046241907 @default.
- W2014751423 cites W2048540864 @default.
- W2014751423 cites W2053702504 @default.
- W2014751423 cites W2054144409 @default.
- W2014751423 cites W2055110202 @default.
- W2014751423 cites W2057375692 @default.
- W2014751423 cites W2070849620 @default.
- W2014751423 cites W2074597244 @default.
- W2014751423 cites W2077855089 @default.
- W2014751423 cites W2078107700 @default.
- W2014751423 cites W2080546144 @default.
- W2014751423 cites W2086331774 @default.
- W2014751423 cites W2091746877 @default.
- W2014751423 cites W2093417867 @default.
- W2014751423 cites W2099681945 @default.
- W2014751423 cites W2101408271 @default.
- W2014751423 cites W2103031848 @default.
- W2014751423 cites W2107022932 @default.
- W2014751423 cites W2107141327 @default.
- W2014751423 cites W2108946209 @default.
- W2014751423 cites W2110881937 @default.
- W2014751423 cites W2111399322 @default.
- W2014751423 cites W2115444433 @default.
- W2014751423 cites W2115686163 @default.
- W2014751423 cites W2118199431 @default.
- W2014751423 cites W2121586803 @default.
- W2014751423 cites W2127588196 @default.
- W2014751423 cites W2162238950 @default.
- W2014751423 cites W2165695219 @default.
- W2014751423 cites W2166919582 @default.
- W2014751423 cites W2396242620 @default.
- W2014751423 doi "https://doi.org/10.1006/dbio.2000.9670" @default.
- W2014751423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10772805" @default.
- W2014751423 hasPublicationYear "2000" @default.
- W2014751423 type Work @default.
- W2014751423 sameAs 2014751423 @default.
- W2014751423 citedByCount "393" @default.
- W2014751423 countsByYear W20147514232012 @default.
- W2014751423 countsByYear W20147514232013 @default.
- W2014751423 countsByYear W20147514232014 @default.
- W2014751423 countsByYear W20147514232015 @default.
- W2014751423 countsByYear W20147514232016 @default.
- W2014751423 countsByYear W20147514232017 @default.
- W2014751423 countsByYear W20147514232018 @default.
- W2014751423 countsByYear W20147514232019 @default.
- W2014751423 countsByYear W20147514232020 @default.
- W2014751423 countsByYear W20147514232021 @default.
- W2014751423 countsByYear W20147514232022 @default.
- W2014751423 countsByYear W20147514232023 @default.
- W2014751423 crossrefType "journal-article" @default.
- W2014751423 hasAuthorship W2014751423A5035885878 @default.
- W2014751423 hasAuthorship W2014751423A5036892364 @default.
- W2014751423 hasAuthorship W2014751423A5046954073 @default.
- W2014751423 hasAuthorship W2014751423A5051004924 @default.
- W2014751423 hasAuthorship W2014751423A5051009186 @default.
- W2014751423 hasAuthorship W2014751423A5072603506 @default.
- W2014751423 hasAuthorship W2014751423A5090298420 @default.
- W2014751423 hasBestOaLocation W20147514231 @default.
- W2014751423 hasConcept C104317684 @default.
- W2014751423 hasConcept C129536746 @default.
- W2014751423 hasConcept C143065580 @default.
- W2014751423 hasConcept C145103041 @default.
- W2014751423 hasConcept C153911025 @default.
- W2014751423 hasConcept C196843134 @default.