FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014754013> ?p ?o ?g. }

• W2014754013 endingPage "26" @default.
• W2014754013 startingPage "21" @default.
• W2014754013 abstract "Interferon (IFN) treatment of chronic hepatitis C virus (HCV) is associated with a high rate of relapse. IFN is thought to exert its effect against HCV via direct viral inhibition and immune stimulation. We have hypothesized that relapse following termination of therapy results from the sudden withdrawal of this immune modulatory effect and that gradual reduction in the IFN dose may decrease the incidence of relapse. One hundred six patients with chronic HCV were enrolled into this 24-month controlled, randomized prospective trial. All were treated with 5 mU of interferon-alpha-2b three times a week for 6 months. Patients who achieved biochemical response were randomized to either stop or taper IFN gradually at monthly intervals as follows; 3 mU, 2 mU, 1 mU, and 0.5 mU (all three times a week). 0.5 mU twice weekly and then once weekly. Liver histology was assessed by Knodell index and HCV RNA was measured by a quantitative polymerase chain reaction (PCR) assay. Of the 92 patients who completed the initial 6 months of IFN treatment, 47 (51%) achieved biochemical response. Twenty-one of these patients were randomized to stop IFN treatment and 25 to taper (1 drop-out). At randomization patients were well matched with respect to age, sex, race, serum alanine transaminase (ALT), and liver histology. Biochemical relapse was observed in 19 of 21 (91%) patients who stopped IFN treatment compared with only 60% who tapered IFN (P= .04). Virological relapse occurred in 90% of patients who stopped and only 48% of persons who tapered IFN therapy. At completion of the 24-month study patients who achieved long-term sustained biochemical response had a significantly lower mean Knodell score (3.5 vs. 6.5) and a significantly greater number were HCV RNA negative in serum (85% vs. 18%) compared with relapsers. We conclude that gradual reduction in IFN dose is associated with a significant higher rate of sustained response and clearance of HCV RNA from serum compared with abruptly stopping treatment. This in turn is associated with a significant improvement in hepatic histology supporting the premise that response to IFN therapy can prevent progression to cirrhosis." @default.
• W2014754013 created "2016-06-24" @default.
• W2014754013 creator A5010968373 @default.
• W2014754013 creator A5018022782 @default.
• W2014754013 creator A5054291707 @default.
• W2014754013 creator A5070639714 @default.
• W2014754013 creator A5073737952 @default.
• W2014754013 creator A5083962400 @default.
• W2014754013 date "1996-07-01" @default.
• W2014754013 modified "2023-10-18" @default.
• W2014754013 title "Improved sustained response following treatment of chronic hepatitis C by gradual reduction in the interferon dose" @default.
• W2014754013 cites W1493607500 @default.
• W2014754013 cites W1550484024 @default.
• W2014754013 cites W1648420719 @default.
• W2014754013 cites W1967481287 @default.
• W2014754013 cites W1985652317 @default.
• W2014754013 cites W1989321942 @default.
• W2014754013 cites W1989682360 @default.
• W2014754013 cites W1992753801 @default.
• W2014754013 cites W2019943793 @default.
• W2014754013 cites W2026062231 @default.
• W2014754013 cites W2033079107 @default.
• W2014754013 cites W2034670242 @default.
• W2014754013 cites W2087924794 @default.
• W2014754013 cites W2089079415 @default.
• W2014754013 cites W2106935734 @default.
• W2014754013 cites W2115956200 @default.
• W2014754013 cites W2119600310 @default.
• W2014754013 cites W2120100896 @default.
• W2014754013 cites W2162111530 @default.
• W2014754013 cites W2162627130 @default.
• W2014754013 cites W2177943720 @default.
• W2014754013 cites W2316240564 @default.
• W2014754013 cites W2332957918 @default.
• W2014754013 cites W2335968781 @default.
• W2014754013 cites W2336799715 @default.
• W2014754013 cites W2096189195 @default.
• W2014754013 doi "https://doi.org/10.1002/hep.510240105" @default.
• W2014754013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8707264" @default.
• W2014754013 hasPublicationYear "1996" @default.
• W2014754013 type Work @default.
• W2014754013 sameAs 2014754013 @default.
• W2014754013 citedByCount "30" @default.
• W2014754013 countsByYear W20147540132020 @default.
• W2014754013 crossrefType "journal-article" @default.
• W2014754013 hasAuthorship W2014754013A5010968373 @default.
• W2014754013 hasAuthorship W2014754013A5018022782 @default.
• W2014754013 hasAuthorship W2014754013A5054291707 @default.
• W2014754013 hasAuthorship W2014754013A5070639714 @default.
• W2014754013 hasAuthorship W2014754013A5073737952 @default.
• W2014754013 hasAuthorship W2014754013A5083962400 @default.
• W2014754013 hasConcept C126322002 @default.
• W2014754013 hasConcept C168563851 @default.
• W2014754013 hasConcept C203014093 @default.
• W2014754013 hasConcept C204243189 @default.
• W2014754013 hasConcept C2522874641 @default.
• W2014754013 hasConcept C2776178377 @default.
• W2014754013 hasConcept C2776408679 @default.
• W2014754013 hasConcept C2776455275 @default.
• W2014754013 hasConcept C2778606649 @default.
• W2014754013 hasConcept C2781228144 @default.
• W2014754013 hasConcept C2909179924 @default.
• W2014754013 hasConcept C71924100 @default.
• W2014754013 hasConcept C90924648 @default.
• W2014754013 hasConceptScore W2014754013C126322002 @default.
• W2014754013 hasConceptScore W2014754013C168563851 @default.
• W2014754013 hasConceptScore W2014754013C203014093 @default.
• W2014754013 hasConceptScore W2014754013C204243189 @default.
• W2014754013 hasConceptScore W2014754013C2522874641 @default.
• W2014754013 hasConceptScore W2014754013C2776178377 @default.
• W2014754013 hasConceptScore W2014754013C2776408679 @default.
• W2014754013 hasConceptScore W2014754013C2776455275 @default.
• W2014754013 hasConceptScore W2014754013C2778606649 @default.
• W2014754013 hasConceptScore W2014754013C2781228144 @default.
• W2014754013 hasConceptScore W2014754013C2909179924 @default.
• W2014754013 hasConceptScore W2014754013C71924100 @default.
• W2014754013 hasConceptScore W2014754013C90924648 @default.
• W2014754013 hasIssue "1" @default.
• W2014754013 hasLocation W20147540131 @default.
• W2014754013 hasLocation W20147540132 @default.
• W2014754013 hasOpenAccess W2014754013 @default.
• W2014754013 hasPrimaryLocation W20147540131 @default.
• W2014754013 hasRelatedWork W2012174757 @default.
• W2014754013 hasRelatedWork W2014374827 @default.
• W2014754013 hasRelatedWork W2052392525 @default.
• W2014754013 hasRelatedWork W2079002457 @default.
• W2014754013 hasRelatedWork W2090324800 @default.
• W2014754013 hasRelatedWork W2152169833 @default.
• W2014754013 hasRelatedWork W2409000725 @default.
• W2014754013 hasRelatedWork W2414437456 @default.
• W2014754013 hasRelatedWork W2416366082 @default.
• W2014754013 hasRelatedWork W80741246 @default.
• W2014754013 hasVolume "24" @default.
• W2014754013 isParatext "false" @default.
• W2014754013 isRetracted "false" @default.
• W2014754013 magId "2014754013" @default.
• W2014754013 workType "article" @default.