Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014754886> ?p ?o ?g. }
- W2014754886 endingPage "2044" @default.
- W2014754886 startingPage "2037" @default.
- W2014754886 abstract "Osteopontin (OPN) is a secreted protein present in bodily fluids and tissues. It is subject to multiple post-translational modifications, including phosphorylation, glycosylation, proteolytic cleavage and crosslinking by transglutamination. Binding of OPN to integrin and CD44 receptors regulates signalling cascades that affect processes such as adhesion, migration, invasion, chemotaxis and cell survival. A variety of cells and tissues express OPN, including bone, vasculature, kidney, inflammatory cells and numerous secretory epithelia. Normal physiological roles include regulation of immune functions, vascular remodelling, wound repair and developmental processes. OPN also is expressed in many cancers, and elevated levels in patients' tumour tissue and blood are associated with poor prognosis. Tumour growth is regulated by interactions between tumour cells and their tissue microenvironment. Within a tumour mass, OPN can be expressed by both tumour cells and cellular components of the tumour microenvironment, and both tumour and normal cells may have receptors able to bind to OPN. OPN can also be found as a component of the extracellular matrix. The functional roles of OPN in a tumour are thus complex, with OPN secreted by both tumour cells and cells in the tumour microenvironment, both of which can in turn respond to OPN. Much remains to be learned about the cross-talk between normal and tumour cells within a tumour, and the role of multiple forms of OPN in these interactions. Understanding OPN-mediated interactions within a tumour will be important for the development of therapeutic strategies to target OPN." @default.
- W2014754886 created "2016-06-24" @default.
- W2014754886 creator A5001630082 @default.
- W2014754886 creator A5028681691 @default.
- W2014754886 creator A5063128052 @default.
- W2014754886 creator A5065205944 @default.
- W2014754886 date "2010-07-01" @default.
- W2014754886 modified "2023-09-26" @default.
- W2014754886 title "Role of the metastasis-promoting protein osteopontin in the tumour microenvironment" @default.
- W2014754886 cites W1480357432 @default.
- W2014754886 cites W1545099746 @default.
- W2014754886 cites W1564926555 @default.
- W2014754886 cites W1572752555 @default.
- W2014754886 cites W1757636880 @default.
- W2014754886 cites W1825214797 @default.
- W2014754886 cites W1965418913 @default.
- W2014754886 cites W1970122533 @default.
- W2014754886 cites W1971156035 @default.
- W2014754886 cites W1971992633 @default.
- W2014754886 cites W1974406951 @default.
- W2014754886 cites W1975675679 @default.
- W2014754886 cites W1980827014 @default.
- W2014754886 cites W1981895579 @default.
- W2014754886 cites W1985691031 @default.
- W2014754886 cites W1985804036 @default.
- W2014754886 cites W1986315113 @default.
- W2014754886 cites W1986471913 @default.
- W2014754886 cites W1988087441 @default.
- W2014754886 cites W1991370238 @default.
- W2014754886 cites W1991753815 @default.
- W2014754886 cites W1991840922 @default.
- W2014754886 cites W1993690997 @default.
- W2014754886 cites W1993869694 @default.
- W2014754886 cites W1996577023 @default.
- W2014754886 cites W1997697459 @default.
- W2014754886 cites W2001124438 @default.
- W2014754886 cites W2003558980 @default.
- W2014754886 cites W2007601283 @default.
- W2014754886 cites W2010680873 @default.
- W2014754886 cites W2010690155 @default.
- W2014754886 cites W2012124753 @default.
- W2014754886 cites W2012927577 @default.
- W2014754886 cites W2015508837 @default.
- W2014754886 cites W2021415784 @default.
- W2014754886 cites W2024066814 @default.
- W2014754886 cites W2024206207 @default.
- W2014754886 cites W2026642739 @default.
- W2014754886 cites W2032006686 @default.
- W2014754886 cites W2033420580 @default.
- W2014754886 cites W2033432174 @default.
- W2014754886 cites W2034332480 @default.
- W2014754886 cites W2037691924 @default.
- W2014754886 cites W2041537003 @default.
- W2014754886 cites W2042583579 @default.
- W2014754886 cites W2045679709 @default.
- W2014754886 cites W2047902687 @default.
- W2014754886 cites W2048457753 @default.
- W2014754886 cites W2049045156 @default.
- W2014754886 cites W2049198267 @default.
- W2014754886 cites W2049866683 @default.
- W2014754886 cites W2055297995 @default.
- W2014754886 cites W2056086060 @default.
- W2014754886 cites W2062809449 @default.
- W2014754886 cites W2063152874 @default.
- W2014754886 cites W2063539736 @default.
- W2014754886 cites W2065262228 @default.
- W2014754886 cites W2069264610 @default.
- W2014754886 cites W2069880766 @default.
- W2014754886 cites W2075267181 @default.
- W2014754886 cites W2086238431 @default.
- W2014754886 cites W2086585598 @default.
- W2014754886 cites W2092754755 @default.
- W2014754886 cites W2095004629 @default.
- W2014754886 cites W2095598121 @default.
- W2014754886 cites W2097489402 @default.
- W2014754886 cites W2098873966 @default.
- W2014754886 cites W2103898770 @default.
- W2014754886 cites W2104516860 @default.
- W2014754886 cites W2110257529 @default.
- W2014754886 cites W2112509531 @default.
- W2014754886 cites W2115300301 @default.
- W2014754886 cites W2115537515 @default.
- W2014754886 cites W2116554142 @default.
- W2014754886 cites W2116858409 @default.
- W2014754886 cites W2120944127 @default.
- W2014754886 cites W2121793520 @default.
- W2014754886 cites W2124724858 @default.
- W2014754886 cites W2127730885 @default.
- W2014754886 cites W2132378346 @default.
- W2014754886 cites W2135569696 @default.
- W2014754886 cites W2139377231 @default.
- W2014754886 cites W2140484012 @default.
- W2014754886 cites W2142490790 @default.
- W2014754886 cites W2143887670 @default.
- W2014754886 cites W2148102207 @default.
- W2014754886 cites W2150350514 @default.
- W2014754886 cites W2153206163 @default.
- W2014754886 cites W2153624488 @default.