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- W2014756576 abstract "Recent in vitro evidences indicate that factors as Parathyroid hormone (PTH) and its related peptide (PTHrp), 1, 25-dihydroxyvitamin D3 and 17β-estradiol (E2) have regulatory effects on mouse- or rat-derived osteoblast-like cells. We studied the effects in vitro of various hormones, i.e. recombinant human growth hormone (r-hGH), PTHrp, 1, 25-dihydroxyvitamin D3 and E2, on type I procollagen (IP) and IGFs binding proteins (IGFBPs) production by human osteosarcoma cells (SaOs). Methods. Cells were cultured in 24-well plates in RPMI-1640 medium. Confluent cultures were added with medium alone (control cultures) or with the various hormones at 10−8 M final concentration in serum-free condition. After 3 days the supernates were recovered and assayed for IP by RIA and IGFBPs by the “ligand blotting” method, using 125I-IGF-I as probe. Results and comment. In the supernates of hormonally-treated cultures IP levels almost doubled the values found in the control ones. The ligand blotting showed the presence of two major bands relative to IGFBP2 and BP4. Such binding proteins had higher levels in the supernates of the hormonally-treated than in the control cultures and, among the hormones used, PTHrp seems the most potent. Thus, our data indicate that PTHrp, r-hGH, 1, 25-dihydroxyvitamin D3 and E2 have important regulatory effects on human osteoblast-like cells not only on bone matrix production but also on proteins that may play an autocrine/paracrine role in bone, as IGFBPs." @default.
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- W2014756576 date "1993-05-01" @default.
- W2014756576 modified "2023-10-18" @default.
- W2014756576 title "EFFECT IN VITRO OF r-hGH AND CALCIOTROPIC HORMONES ON HUMAN OSTEOBLAST-LIKE CELLS" @default.
- W2014756576 doi "https://doi.org/10.1203/00006450-199305001-00462" @default.
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