Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014757222> ?p ?o ?g. }
- W2014757222 endingPage "389" @default.
- W2014757222 startingPage "373" @default.
- W2014757222 abstract "Although the introduction of highly active antiretroviral therapy (HAART) has led to a significant reduction in AIDS-related morbidity and mortality, unfortunately, many patients discontinue their initial HAART regimen, resulting in development of viral resistance. During HIV infection, the viral activator Tat is needed for viral progeny formation, and the basic and core domains of Tat are the most conserved parts of the protein. Here, we show that a Tat 41/44 peptide from the core domain can inhibit HIV-1 gene expression and replication. The peptides are not toxic to cells and target the Cdk2/Cyclin E complex, inhibiting the phosphorylation of serine 5 of RNAPII. Using the Cdk2 X-ray crystallography structure, we found that the low-energy wild-type peptides could bind to the ATP binding pocket, whereas the mutant peptide bound to the Cdk2 interface. Finally, we show that these peptides do not allow loading of the catalytic domain of the cdk/cyclin complex onto the HIV-1 promoter in vivo." @default.
- W2014757222 created "2016-06-24" @default.
- W2014757222 creator A5016433275 @default.
- W2014757222 creator A5016700147 @default.
- W2014757222 creator A5019194282 @default.
- W2014757222 creator A5020737342 @default.
- W2014757222 creator A5022311364 @default.
- W2014757222 creator A5061649532 @default.
- W2014757222 creator A5088663673 @default.
- W2014757222 date "2006-02-01" @default.
- W2014757222 modified "2023-09-25" @default.
- W2014757222 title "Inhibition of HIV-1 virus replication using small soluble Tat peptides" @default.
- W2014757222 cites W1488192195 @default.
- W2014757222 cites W1518524366 @default.
- W2014757222 cites W1575088319 @default.
- W2014757222 cites W1586243412 @default.
- W2014757222 cites W1605366962 @default.
- W2014757222 cites W1622061844 @default.
- W2014757222 cites W177084162 @default.
- W2014757222 cites W1865335929 @default.
- W2014757222 cites W1918714789 @default.
- W2014757222 cites W1941458089 @default.
- W2014757222 cites W1964658039 @default.
- W2014757222 cites W1966383348 @default.
- W2014757222 cites W1966425882 @default.
- W2014757222 cites W1966975236 @default.
- W2014757222 cites W1972370047 @default.
- W2014757222 cites W1976280089 @default.
- W2014757222 cites W1977569407 @default.
- W2014757222 cites W1982655250 @default.
- W2014757222 cites W1982685209 @default.
- W2014757222 cites W1983533964 @default.
- W2014757222 cites W1984064054 @default.
- W2014757222 cites W1985844240 @default.
- W2014757222 cites W1988904557 @default.
- W2014757222 cites W1989415425 @default.
- W2014757222 cites W1990957349 @default.
- W2014757222 cites W1995953390 @default.
- W2014757222 cites W1998820273 @default.
- W2014757222 cites W1999158418 @default.
- W2014757222 cites W2001021440 @default.
- W2014757222 cites W2002114666 @default.
- W2014757222 cites W2006931677 @default.
- W2014757222 cites W2007691102 @default.
- W2014757222 cites W2007801829 @default.
- W2014757222 cites W2008391205 @default.
- W2014757222 cites W2010090319 @default.
- W2014757222 cites W2015620966 @default.
- W2014757222 cites W2015880637 @default.
- W2014757222 cites W2017769971 @default.
- W2014757222 cites W2019518442 @default.
- W2014757222 cites W2028800022 @default.
- W2014757222 cites W2031189364 @default.
- W2014757222 cites W2034903767 @default.
- W2014757222 cites W2035516686 @default.
- W2014757222 cites W2038143561 @default.
- W2014757222 cites W2040132563 @default.
- W2014757222 cites W2040347867 @default.
- W2014757222 cites W2046135441 @default.
- W2014757222 cites W2046336423 @default.
- W2014757222 cites W2046854154 @default.
- W2014757222 cites W2048792281 @default.
- W2014757222 cites W2050682981 @default.
- W2014757222 cites W2051627027 @default.
- W2014757222 cites W2056114994 @default.
- W2014757222 cites W2057290799 @default.
- W2014757222 cites W2059083953 @default.
- W2014757222 cites W2060554618 @default.
- W2014757222 cites W2060699984 @default.
- W2014757222 cites W2060737830 @default.
- W2014757222 cites W2060913542 @default.
- W2014757222 cites W2061025027 @default.
- W2014757222 cites W2068170981 @default.
- W2014757222 cites W2072916562 @default.
- W2014757222 cites W2074395777 @default.
- W2014757222 cites W2077210299 @default.
- W2014757222 cites W2078246081 @default.
- W2014757222 cites W2078712088 @default.
- W2014757222 cites W2079258572 @default.
- W2014757222 cites W2079612556 @default.
- W2014757222 cites W2081322742 @default.
- W2014757222 cites W2083804862 @default.
- W2014757222 cites W2088120691 @default.
- W2014757222 cites W2088913708 @default.
- W2014757222 cites W2098518481 @default.
- W2014757222 cites W2100973614 @default.
- W2014757222 cites W2101296785 @default.
- W2014757222 cites W2102380059 @default.
- W2014757222 cites W2105192976 @default.
- W2014757222 cites W2106762061 @default.
- W2014757222 cites W2107174433 @default.
- W2014757222 cites W2113604152 @default.
- W2014757222 cites W2114151755 @default.
- W2014757222 cites W2118555821 @default.
- W2014757222 cites W2120913484 @default.
- W2014757222 cites W2123812291 @default.
- W2014757222 cites W2125177581 @default.
- W2014757222 cites W2129899421 @default.