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- W2014758069 abstract "High concentrations of PGE2 and PGF2α were identified by radio-immunoassay (RIA) and/or gas chromatography/mass spectrometry (GC/MS) in the hemolymph, salivary glands and saliva of the lone star tick Amblyomma americanum (L.). Binding studies indicated that PGE2 was free and not bound to any proteins in the hemolymph. A small amount of 6-keto-PGF1α (breakdown product of PGI2; prostacyclin) was also found in the salivary glands but not in the hemolymph or saliva. Neither PGD2 nor PGA2/B2 was detected in any tick material investigated. Although PGE2 was found in the gut contents, only small amounts of label crossed the gut into the hemolymph during artificial feeding with labeled PGE2, indicating that the high amounts of PGE2 in hemolymph and salivary glands are not sequestered from the host blood meal. Isolated salivary glands and salivary gland homogenates demonstrated robust synthesis of PGE2 at high concentrations of exogenous arachidonic acid. Synthesis by the salivary glands was monitored by measuring increasing PGE2 with increasing arachidonic acid by RIA, GC/MS and labeled PGE2 in the presence of labeled arachidonic acid. Synthesis was inhibited in a dose-dependent manner by indomethacin indicating that the cyclooxygenase synthesizing prostaglandins in ticks shares similarities to the enzyme found in mammals." @default.
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- W2014758069 date "2002-03-01" @default.
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- W2014758069 title "Identity and synthesis of prostaglandins in the lone star tick, Amblyomma americanum (L.), as assessed by radio-immunoassay and gas chromatography/mass spectrometry" @default.
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- W2014758069 doi "https://doi.org/10.1016/s0965-1748(01)00113-8" @default.
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