FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014760247> ?p ?o ?g. }

• W2014760247 endingPage "50" @default.
• W2014760247 startingPage "43" @default.
• W2014760247 abstract "In many women, aversive psychological and somatic symptoms develop during the late luteal phase of the menstrual cycle, when progesterone levels fall sharply. Following intravenous administration in anaesthetised rats, the progesterone metabolite allopregnanolone readily gained access to the periaqueductal grey (PAG), a region involved in generating panic-like anxiety, and inhibited neural activity via actions at GABAA receptors. Withdrawal of female rats from prolonged systemic dosing with progesterone leads to increased numbers of α4, β1 and δ GABAA receptor subunit-immunoreactive neurones in the PAG. In naturally cycling rats a similar upregulation occurred during late dioestrus, when progesterone levels fall. Functional experiments revealed that upregulation of α4β1δ receptor subunit expression was associated with a decrease in GABAergic tone in the PAG and increased responsiveness to a panicogenic CCK2 receptor agonist. The oestrous cycle-linked plasticity of GABA receptors was absent in rats housed in quiet conditions in an isolated room suggesting that environmental factors may be able to influence the central response to hormonal changes. In susceptible animals, i.e. those housed in a communal animal holding room, oestrous cycle-related changes in GABAergic circuits may underlie the development of increased anxiety levels that represent a rodent counterpart to premenstrual syndrome in women." @default.
• W2014760247 created "2016-06-24" @default.
• W2014760247 creator A5050645796 @default.
• W2014760247 date "2008-07-01" @default.
• W2014760247 modified "2023-09-30" @default.
• W2014760247 title "GABA in the female brain — Oestrous cycle-related changes in GABAergic function in the periaqueductal grey matter" @default.
• W2014760247 cites W1506582057 @default.
• W2014760247 cites W1647312149 @default.
• W2014760247 cites W1771372085 @default.
• W2014760247 cites W1921693572 @default.
• W2014760247 cites W1964544239 @default.
• W2014760247 cites W1970843817 @default.
• W2014760247 cites W1973671944 @default.
• W2014760247 cites W1985367308 @default.
• W2014760247 cites W1985852839 @default.
• W2014760247 cites W1990291379 @default.
• W2014760247 cites W1990778763 @default.
• W2014760247 cites W1994130816 @default.
• W2014760247 cites W1997043298 @default.
• W2014760247 cites W2001744091 @default.
• W2014760247 cites W2010852471 @default.
• W2014760247 cites W2021450290 @default.
• W2014760247 cites W2024394464 @default.
• W2014760247 cites W2030079440 @default.
• W2014760247 cites W2046599344 @default.
• W2014760247 cites W2051174877 @default.
• W2014760247 cites W2055706162 @default.
• W2014760247 cites W2059560647 @default.
• W2014760247 cites W2063132305 @default.
• W2014760247 cites W2063771029 @default.
• W2014760247 cites W2071448790 @default.
• W2014760247 cites W2072370095 @default.
• W2014760247 cites W2073214521 @default.
• W2014760247 cites W2073397309 @default.
• W2014760247 cites W2081626609 @default.
• W2014760247 cites W2103715310 @default.
• W2014760247 cites W2105739669 @default.
• W2014760247 cites W2126484663 @default.
• W2014760247 cites W2150921052 @default.
• W2014760247 cites W2323408668 @default.
• W2014760247 cites W4235882036 @default.
• W2014760247 cites W4245117662 @default.
• W2014760247 cites W4253079162 @default.
• W2014760247 doi "https://doi.org/10.1016/j.pbb.2007.12.014" @default.
• W2014760247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18261785" @default.
• W2014760247 hasPublicationYear "2008" @default.
• W2014760247 type Work @default.
• W2014760247 sameAs 2014760247 @default.
• W2014760247 citedByCount "36" @default.
• W2014760247 countsByYear W20147602472012 @default.
• W2014760247 countsByYear W20147602472013 @default.
• W2014760247 countsByYear W20147602472014 @default.
• W2014760247 countsByYear W20147602472015 @default.
• W2014760247 countsByYear W20147602472016 @default.
• W2014760247 countsByYear W20147602472018 @default.
• W2014760247 countsByYear W20147602472021 @default.
• W2014760247 countsByYear W20147602472022 @default.
• W2014760247 countsByYear W20147602472023 @default.
• W2014760247 crossrefType "journal-article" @default.
• W2014760247 hasAuthorship W2014760247A5050645796 @default.
• W2014760247 hasConcept C104317684 @default.
• W2014760247 hasConcept C126322002 @default.
• W2014760247 hasConcept C127561419 @default.
• W2014760247 hasConcept C134018914 @default.
• W2014760247 hasConcept C168258287 @default.
• W2014760247 hasConcept C170493617 @default.
• W2014760247 hasConcept C1998276 @default.
• W2014760247 hasConcept C2778338918 @default.
• W2014760247 hasConcept C2778938600 @default.
• W2014760247 hasConcept C2779058012 @default.
• W2014760247 hasConcept C2779177108 @default.
• W2014760247 hasConcept C44796713 @default.
• W2014760247 hasConcept C55493867 @default.
• W2014760247 hasConcept C71315377 @default.
• W2014760247 hasConcept C71924100 @default.
• W2014760247 hasConcept C86803240 @default.
• W2014760247 hasConceptScore W2014760247C104317684 @default.
• W2014760247 hasConceptScore W2014760247C126322002 @default.
• W2014760247 hasConceptScore W2014760247C127561419 @default.
• W2014760247 hasConceptScore W2014760247C134018914 @default.
• W2014760247 hasConceptScore W2014760247C168258287 @default.
• W2014760247 hasConceptScore W2014760247C170493617 @default.
• W2014760247 hasConceptScore W2014760247C1998276 @default.
• W2014760247 hasConceptScore W2014760247C2778338918 @default.
• W2014760247 hasConceptScore W2014760247C2778938600 @default.
• W2014760247 hasConceptScore W2014760247C2779058012 @default.
• W2014760247 hasConceptScore W2014760247C2779177108 @default.
• W2014760247 hasConceptScore W2014760247C44796713 @default.
• W2014760247 hasConceptScore W2014760247C55493867 @default.
• W2014760247 hasConceptScore W2014760247C71315377 @default.
• W2014760247 hasConceptScore W2014760247C71924100 @default.
• W2014760247 hasConceptScore W2014760247C86803240 @default.
• W2014760247 hasIssue "1" @default.
• W2014760247 hasLocation W20147602471 @default.
• W2014760247 hasLocation W20147602472 @default.
• W2014760247 hasOpenAccess W2014760247 @default.
• W2014760247 hasPrimaryLocation W20147602471 @default.
• W2014760247 hasRelatedWork W1484579537 @default.

• next