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• W2014760571 abstract "Since the early observations of Malzberg in 1937, 1 Malzberg B Mortality among patients with involution melancholia. Am J Psychiatry. 1937; 93: 1231-1238 Crossref Google Scholar there has been an awareness in psychiatry that patients with severe psychiatric disorders, particularly depression, are at increased risk for death from cardiovascular disease. 2 Weeke A Schou M Strongen E Prevention and Treatment of Affective Disorders. Academic Press, London1979: 288-299 Google Scholar Subsequent work focused on type A personality and hostility as predisposing factors in the development of coronary artery disease (CAD) and myocardial infarction. 3 Dimsdale JE A perspective on Type A behavior and coronary disease. N Engl J Med. 1988; 318: 110-112 Crossref PubMed Scopus (78) Google Scholar In the last 15 years, there has been a veritable explosion in research at the interface of cardiology and psychiatry with a focus on mood disorders. 4 Evans DL Charney DS Lewis L et al. Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry. 2005; 58: 175-189 Abstract Full Text Full Text PDF PubMed Scopus (841) Google Scholar I briefly review this burgeoning literature and then focus on the four manuscripts in this issue that further inform the field. To summarize the field, six major findings are highlighted: 1) Patients with ischemic heart disease exhibit high rates of both syndromal depression and subsyndromal depressive symptoms, far higher than that observed in the general population; 2) Depression is a major and independent risk factor for the development of CAD and stroke; 3) In patients post myocardial infarction, depression is a major risk factor for poor outcome, both in terms of morbidity and mortality; 4) Several pathophysiologic mechanisms have been identified that contribute to the increased risk of myocardial infarction and stroke in depressed patients including abnormalities in the platelet clotting cascade, decreased heart rate variability (HRV), increased inflammation, and alterations in brain regions that modulate cardiovascular responses; 5) The findings described above concerning depression and CAD or myocardial infarction also seem to be equally applicable to congestive heart failure, outcome of coronary artery bypass surgery, and stroke; 6) Treatment of depression with antidepressants in patients with comorbid cardiovascular or cerebrovascular disease is safe and effective. Because vascular disease is very common in the elderly, it is of great interest to focus on these comorbidities in this risk population. That is generally the focus of four reports in the current issue of the American Journal of Geriatric Psychiatry." @default.
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• W2014760571 date "2008-11-01" @default.
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• W2014760571 title "The Curiously Strong Relationship Between Cardiovascular Disease and Depression in the Elderly" @default.
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• W2014760571 doi "https://doi.org/10.1097/jgp.0b013e318189806a" @default.
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