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- W2014760586 abstract "In cells infected by herpes simplex virus type 1 (HSV1), a series of nuclear changes can be observed in a temporal sequence. Such changes are related to important modifications in the higher-order structure of host cell chromatin, such as loss of DNA loop supercoiling and wholesale DNA loop disorganization. It is known that the topological relationship between DNA and the nuclear substructure is a critical factor for proper nuclear physiology. Here we report that the usual association between newly replicated DNA and the nuclear substructure, commonly known as nuclear matrix, is abrogated in cells infected by HSV1, thus establishing a correlation between the virus-induced modifications in chromatin higher-order structure and a major biochemical change within the infected cell nucleus. Dans les cellules infectées par le virus de l'herpes simplex de type 1 (VHS1) on observe une suite séquentielle de modifications nucléaires ; et de telles modifications sont en relation avec d'importantes modifications de la superstructure de la chromatine cellulaire, en l'occurrence, des perturbations diverses au niveau de la boucle d'ADN; sachant que la relation topologique entre l'ADN et la sous-structure nucléaire est un facteur critique de la physiologie nucléaire, nous avons étudié l'association habituelle entre l'ADN fraîchement répliqué et la sous-structure nucléaire (appelée communément matrice nucléaire): cette association est supprimée dans les cellules infectées par le VHS1. Cela démontre l'existence d'une corrélation entre les modifications induites par le virus dans la superstructure chromatinienne et une modification biochimique majeure observée dans le noyau de la cellule infectée." @default.
- W2014760586 created "2016-06-24" @default.
- W2014760586 creator A5047394387 @default.
- W2014760586 date "1998-07-01" @default.
- W2014760586 modified "2023-09-26" @default.
- W2014760586 title "The normal association between newly replicated DNA and the nuclear matrix is abolished in cells infected by herpes simplex virus type 1" @default.
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- W2014760586 doi "https://doi.org/10.1016/s0923-2516(98)80001-0" @default.
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