FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014761639> ?p ?o ?g. }

• W2014761639 endingPage "352" @default.
• W2014761639 startingPage "345" @default.
• W2014761639 abstract "Cell numbers in above-ground meristems of plants are thought to be maintained by a feedback loop driven by perception of the glycopeptide ligand CLAVATA3 (CLV3) by the CLAVATA1 (CLV1) receptor kinase and the CLV2/CORYNE (CRN) receptor-like complex. CLV3 produced in the stem cells at the meristem apex limits the expression level of the stem cell-promoting homeodomain protein WUSCHEL (WUS) in the cells beneath, where CLV1 and WUS RNA are localized. WUS downregulation nonautonomously reduces stem cell proliferation. Overexpression of CLV3 eliminates the stem cells, causing meristem termination, and loss of CLV3 function allows meristem overproliferation. There are many questions regarding the CLV3/CLV1 interaction, including where in the meristem it occurs, how it is regulated, and how it is that a large range of CLV3 concentrations gives no meristem size phenotype.Here we use genetics and live imaging to examine the cell biology of CLV1 in Arabidopsis meristematic tissue. We demonstrate that plasma membrane-localized CLV1 is reduced in concentration by CLV3, which causes trafficking of CLV1 to lytic vacuoles. We find that changes in CLV2 activity have no detectable effects on CLV1 levels. We also find that CLV3 appears to diffuse broadly in meristems, contrary to a recent sequestration model.This study provides a new model for CLV1 function in plant stem cell maintenance and suggests that downregulation of plasma membrane-localized CLV1 by its CLV3 ligand can account for the buffering of CLV3 signaling in the maintenance of stem cell pools in plants." @default.
• W2014761639 created "2016-06-24" @default.
• W2014761639 creator A5033968911 @default.
• W2014761639 creator A5060790753 @default.
• W2014761639 creator A5064792085 @default.
• W2014761639 creator A5082944327 @default.
• W2014761639 creator A5089126635 @default.
• W2014761639 date "2011-03-01" @default.
• W2014761639 modified "2023-10-13" @default.
• W2014761639 title "Plant Stem Cell Signaling Involves Ligand-Dependent Trafficking of the CLAVATA1 Receptor Kinase" @default.
• W2014761639 cites W1965355812 @default.
• W2014761639 cites W1967601510 @default.
• W2014761639 cites W1968092805 @default.
• W2014761639 cites W1985023202 @default.
• W2014761639 cites W1989726653 @default.
• W2014761639 cites W1990641591 @default.
• W2014761639 cites W2035650943 @default.
• W2014761639 cites W2037353000 @default.
• W2014761639 cites W2042838204 @default.
• W2014761639 cites W2044217417 @default.
• W2014761639 cites W2046103512 @default.
• W2014761639 cites W2047397802 @default.
• W2014761639 cites W2056442594 @default.
• W2014761639 cites W2058300597 @default.
• W2014761639 cites W2068417946 @default.
• W2014761639 cites W2068588120 @default.
• W2014761639 cites W2070215364 @default.
• W2014761639 cites W2080992822 @default.
• W2014761639 cites W2091567597 @default.
• W2014761639 cites W2092212990 @default.
• W2014761639 cites W2098769040 @default.
• W2014761639 cites W2105404273 @default.
• W2014761639 cites W2116909242 @default.
• W2014761639 cites W2117570070 @default.
• W2014761639 cites W2136341461 @default.
• W2014761639 cites W2138841154 @default.
• W2014761639 cites W2140513153 @default.
• W2014761639 cites W2145593659 @default.
• W2014761639 cites W2145866502 @default.
• W2014761639 cites W2149079427 @default.
• W2014761639 cites W2151319306 @default.
• W2014761639 cites W2155536094 @default.
• W2014761639 cites W2156413023 @default.
• W2014761639 cites W2157294409 @default.
• W2014761639 cites W2158260463 @default.
• W2014761639 cites W2161060432 @default.
• W2014761639 cites W2161460195 @default.
• W2014761639 cites W2168079189 @default.
• W2014761639 cites W2169393691 @default.
• W2014761639 cites W4212814752 @default.
• W2014761639 doi "https://doi.org/10.1016/j.cub.2011.01.039" @default.
• W2014761639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3072602" @default.
• W2014761639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21333538" @default.
• W2014761639 hasPublicationYear "2011" @default.
• W2014761639 type Work @default.
• W2014761639 sameAs 2014761639 @default.
• W2014761639 citedByCount "119" @default.
• W2014761639 countsByYear W20147616392012 @default.
• W2014761639 countsByYear W20147616392013 @default.
• W2014761639 countsByYear W20147616392014 @default.
• W2014761639 countsByYear W20147616392015 @default.
• W2014761639 countsByYear W20147616392016 @default.
• W2014761639 countsByYear W20147616392017 @default.
• W2014761639 countsByYear W20147616392018 @default.
• W2014761639 countsByYear W20147616392019 @default.
• W2014761639 countsByYear W20147616392020 @default.
• W2014761639 countsByYear W20147616392021 @default.
• W2014761639 countsByYear W20147616392022 @default.
• W2014761639 countsByYear W20147616392023 @default.
• W2014761639 crossrefType "journal-article" @default.
• W2014761639 hasAuthorship W2014761639A5033968911 @default.
• W2014761639 hasAuthorship W2014761639A5060790753 @default.
• W2014761639 hasAuthorship W2014761639A5064792085 @default.
• W2014761639 hasAuthorship W2014761639A5082944327 @default.
• W2014761639 hasAuthorship W2014761639A5089126635 @default.
• W2014761639 hasBestOaLocation W20147616391 @default.
• W2014761639 hasConcept C104317684 @default.
• W2014761639 hasConcept C126021549 @default.
• W2014761639 hasConcept C127561419 @default.
• W2014761639 hasConcept C143065580 @default.
• W2014761639 hasConcept C1491633281 @default.
• W2014761639 hasConcept C150194340 @default.
• W2014761639 hasConcept C162317418 @default.
• W2014761639 hasConcept C2775988993 @default.
• W2014761639 hasConcept C2779491563 @default.
• W2014761639 hasConcept C28328180 @default.
• W2014761639 hasConcept C54355233 @default.
• W2014761639 hasConcept C86803240 @default.
• W2014761639 hasConcept C95444343 @default.
• W2014761639 hasConceptScore W2014761639C104317684 @default.
• W2014761639 hasConceptScore W2014761639C126021549 @default.
• W2014761639 hasConceptScore W2014761639C127561419 @default.
• W2014761639 hasConceptScore W2014761639C143065580 @default.
• W2014761639 hasConceptScore W2014761639C1491633281 @default.
• W2014761639 hasConceptScore W2014761639C150194340 @default.
• W2014761639 hasConceptScore W2014761639C162317418 @default.
• W2014761639 hasConceptScore W2014761639C2775988993 @default.
• W2014761639 hasConceptScore W2014761639C2779491563 @default.

• next