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- W2014763995 abstract "1. The motor effect of the α2 adrenoreceptor antagonist, idazoxan, was compared to that of L-dopa in MPTP-treated monkeys. 2. Idazoxan 2.0 mg/kg improved parkinsonian motor abnormalities which was comparable to the effects of a minimal effective dose of L-dopa. 3. At 2.0 and 5.0 mg/kg, the parkinsonian rigidity was the item most frequently alleviated by idazoxan (respectively 63.6% and 68.2%). 4. These findings provide support for the therapeutic utility of α2 antagonists in the treatment of Parkinson's disease." @default.
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- W2014763995 title "Effect of the α2 adrenoreceptor antagonist, idazoxan, on motor disabilities in MPTP-treated monkey" @default.
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- W2014763995 doi "https://doi.org/10.1016/s0278-5846(99)00067-6" @default.
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