FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014764322> ?p ?o ?g. }

• W2014764322 endingPage "755" @default.
• W2014764322 startingPage "743" @default.
• W2014764322 abstract "Supraphysiological concentrations of recombinant activated factor VII (rVIIa, NovoSeven) are used to control bleeding in hemophilia. Current experimental evidence suggests that rVIIa may increase thrombin generation via two pathways: one being tissue factor (TF)-dependent and another being activated platelet-dependent. Contribution of TF to the rVIIa action may justify different administration profiles of rVIIa. In the present study, thrombin and fibrin generation and spatial clot formation assays in platelet-free hemophilia A and normal plasma were used to investigate this contribution. By varying the concentration of TF and the way it becomes available to plasma, we obtained the following results. Activation of clotting with less than 5 pmol/l of TF facilitates thrombin and fibrin generation at low, but not at supraphysiological rVIIa concentrations. Activation with more than 13 pmol/l of TF saturates thrombin and fibrin generation kinetics, making it insensitive to rVIIa. rVIIa minimally modulates clot growth on the surface of TF-expressing fibroblasts. On the contrary, rVIIa produces spontaneous clot formation in nonflowing platelet-free plasma far away from fibroblasts via plasma lipid particles. Therefore, both the concentration and the distribution of TF determine relevance of a particular experimental system for the studies of rVIIa action. The results indicate that 300–1600 nmol/l (megadoses) of rVIIa may deliver coagulation outside of the TF-rich areas of blood vessel damage via the platelet-derived microparticles. Therefore, rate and extent of platelet-derived microparticles generation might be important with regard to rVIIa treatment safety." @default.
• W2014764322 created "2016-06-24" @default.
• W2014764322 creator A5001629921 @default.
• W2014764322 creator A5019924093 @default.
• W2014764322 creator A5035010200 @default.
• W2014764322 creator A5039717346 @default.
• W2014764322 creator A5051457552 @default.
• W2014764322 creator A5057748570 @default.
• W2014764322 creator A5058001042 @default.
• W2014764322 creator A5072126995 @default.
• W2014764322 creator A5079066965 @default.
• W2014764322 date "2008-12-01" @default.
• W2014764322 modified "2023-10-13" @default.
• W2014764322 title "Mechanisms of action of recombinant activated factor VII in the context of tissue factor concentration and distribution" @default.
• W2014764322 cites W110545565 @default.
• W2014764322 cites W1543302782 @default.
• W2014764322 cites W1780974004 @default.
• W2014764322 cites W1837090086 @default.
• W2014764322 cites W1840889595 @default.
• W2014764322 cites W1888008068 @default.
• W2014764322 cites W194949005 @default.
• W2014764322 cites W1979734406 @default.
• W2014764322 cites W1988079576 @default.
• W2014764322 cites W1997685722 @default.
• W2014764322 cites W1998000461 @default.
• W2014764322 cites W1999317790 @default.
• W2014764322 cites W2019235807 @default.
• W2014764322 cites W2030439696 @default.
• W2014764322 cites W2031515989 @default.
• W2014764322 cites W2034975785 @default.
• W2014764322 cites W2037652834 @default.
• W2014764322 cites W2039466802 @default.
• W2014764322 cites W2041726150 @default.
• W2014764322 cites W2046936517 @default.
• W2014764322 cites W2047790770 @default.
• W2014764322 cites W2050655530 @default.
• W2014764322 cites W2052119252 @default.
• W2014764322 cites W2052867868 @default.
• W2014764322 cites W2054434160 @default.
• W2014764322 cites W2081596198 @default.
• W2014764322 cites W2094150968 @default.
• W2014764322 cites W2108446523 @default.
• W2014764322 cites W2118310160 @default.
• W2014764322 cites W2120677427 @default.
• W2014764322 cites W2120722937 @default.
• W2014764322 cites W2120739142 @default.
• W2014764322 cites W2126513998 @default.
• W2014764322 cites W2132984496 @default.
• W2014764322 cites W2133063869 @default.
• W2014764322 cites W2139192027 @default.
• W2014764322 cites W2142521608 @default.
• W2014764322 cites W2148505112 @default.
• W2014764322 cites W2152698413 @default.
• W2014764322 cites W2162841652 @default.
• W2014764322 cites W2168183582 @default.
• W2014764322 cites W2169695797 @default.
• W2014764322 cites W2171269051 @default.
• W2014764322 cites W25090560 @default.
• W2014764322 cites W321003982 @default.
• W2014764322 cites W38825290 @default.
• W2014764322 cites W4322697035 @default.
• W2014764322 doi "https://doi.org/10.1097/mbc.0b013e3283104093" @default.
• W2014764322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19002040" @default.
• W2014764322 hasPublicationYear "2008" @default.
• W2014764322 type Work @default.
• W2014764322 sameAs 2014764322 @default.
• W2014764322 citedByCount "30" @default.
• W2014764322 countsByYear W20147643222012 @default.
• W2014764322 countsByYear W20147643222013 @default.
• W2014764322 countsByYear W20147643222014 @default.
• W2014764322 countsByYear W20147643222015 @default.
• W2014764322 countsByYear W20147643222016 @default.
• W2014764322 countsByYear W20147643222018 @default.
• W2014764322 countsByYear W20147643222020 @default.
• W2014764322 countsByYear W20147643222023 @default.
• W2014764322 crossrefType "journal-article" @default.
• W2014764322 hasAuthorship W2014764322A5001629921 @default.
• W2014764322 hasAuthorship W2014764322A5019924093 @default.
• W2014764322 hasAuthorship W2014764322A5035010200 @default.
• W2014764322 hasAuthorship W2014764322A5039717346 @default.
• W2014764322 hasAuthorship W2014764322A5051457552 @default.
• W2014764322 hasAuthorship W2014764322A5057748570 @default.
• W2014764322 hasAuthorship W2014764322A5058001042 @default.
• W2014764322 hasAuthorship W2014764322A5072126995 @default.
• W2014764322 hasAuthorship W2014764322A5079066965 @default.
• W2014764322 hasConcept C104317684 @default.
• W2014764322 hasConcept C126322002 @default.
• W2014764322 hasConcept C151730666 @default.
• W2014764322 hasConcept C185592680 @default.
• W2014764322 hasConcept C186738567 @default.
• W2014764322 hasConcept C203014093 @default.
• W2014764322 hasConcept C2777292125 @default.
• W2014764322 hasConcept C2778382381 @default.
• W2014764322 hasConcept C2778589496 @default.
• W2014764322 hasConcept C2778961111 @default.
• W2014764322 hasConcept C2779343474 @default.
• W2014764322 hasConcept C2780930249 @default.
• W2014764322 hasConcept C2781221834 @default.

• next