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• W2014765513 abstract "Abstract K + channels and ionotropic glutamate receptors are thought to share a common architecture in their transmembrane pores. This oft-cited hypothesis has been derived from sequence comparisons, topology profiling and analogies to a bacterial glutamate receptor with a K + -channel pore. Although none of these arguments provides sufficient evidence for structural kinship, existing structural data and a new pedigree of bacterial glutamate receptors offer strong support. Comparisons of the patterns of pore-lining residues and mapping of functional determinants reveal extensive structural similarities, and new homologs of bacterial glutamate receptors strengthen the evolutionary link between glutamate receptors and K + channels." @default.
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• W2014765513 date "2003-01-01" @default.
• W2014765513 modified "2023-09-26" @default.
• W2014765513 title "A common architecture for K+ channels and ionotropic glutamate receptors?" @default.
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• W2014765513 doi "https://doi.org/10.1016/s0166-2236(02)00010-3" @default.
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