FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014767959> ?p ?o ?g. }

• W2014767959 endingPage "E523" @default.
• W2014767959 startingPage "E518" @default.
• W2014767959 abstract "Klinefelter syndrome (KS) is the most common chromosome disorder in men (47,XXY), exhibiting a phenotype with marked variation and increased morbidity. The pathophysiological link between the supernumerary X chromosome and the clinical phenotype remains unknown.To elucidate whether differential gene expression patterns can be detected in KS patients and whether these are related to inherent clinical features.EXAKT (Epigenetics, X-chromosomal Features and Clinical Applications in Klinefelter Syndrome Trial) is a Münster-based prospective project involving 132 Klinefelter men and their parents. A range of cardiovascular, inflammatory, and metabolic factors, in comparison to age-matched male (n = 50)/female controls (n = 50) and in relation to genetic features, is assessed.Our predefined hypothesis was that differential gene expression patterns in blood cells exist in KS patients vs male controls and are related to the clinical phenotype.Differential expression of 36 X-chromosomal and autosomal genes put KS patients into a unique genetic setting vs male and female controls. The KS cohort exhibited increased insulin resistance, enhanced inflammatory and procoagulatory status, higher waist circumference, dyslipidemia, and a markedly shorter 12-lead electrocardiogram QTc interval (partly located within the pathological range) vs male controls (all P < .001). Clinical dyshomeostasis was associated with expression patterns of dysregulated genes (all P < .01). Parental origin of the supernumerary X chromosome was a confounder regarding insulin resistance and cardiac phenotype (P < .05). Results are considered preliminary because gene expression was measured in blood cells.The supernumerary X chromosome contributes to a number of pathologies in KS. The pattern of gene expression is altered in KS, and the degree of differential gene expression is associated with the clinical phenotype." @default.
• W2014767959 created "2016-06-24" @default.
• W2014767959 creator A5006152198 @default.
• W2014767959 creator A5022099945 @default.
• W2014767959 creator A5033834367 @default.
• W2014767959 creator A5037897862 @default.
• W2014767959 creator A5048402117 @default.
• W2014767959 creator A5055275116 @default.
• W2014767959 creator A5061585561 @default.
• W2014767959 creator A5081465085 @default.
• W2014767959 date "2015-03-01" @default.
• W2014767959 modified "2023-10-12" @default.
• W2014767959 title "Gene Expression Patterns in Relation to the Clinical Phenotype in Klinefelter Syndrome" @default.
• W2014767959 cites W1555489744 @default.
• W2014767959 cites W1582394831 @default.
• W2014767959 cites W1987624943 @default.
• W2014767959 cites W1995938276 @default.
• W2014767959 cites W2031243089 @default.
• W2014767959 cites W2046616280 @default.
• W2014767959 cites W2047777772 @default.
• W2014767959 cites W2050017294 @default.
• W2014767959 cites W2059233508 @default.
• W2014767959 cites W2072857138 @default.
• W2014767959 cites W2074950840 @default.
• W2014767959 cites W2077833546 @default.
• W2014767959 cites W2082462833 @default.
• W2014767959 cites W2118525500 @default.
• W2014767959 cites W2120588526 @default.
• W2014767959 cites W2125936600 @default.
• W2014767959 cites W2143104968 @default.
• W2014767959 cites W2149586068 @default.
• W2014767959 cites W2167608748 @default.
• W2014767959 cites W64123695 @default.
• W2014767959 doi "https://doi.org/10.1210/jc.2014-2780" @default.
• W2014767959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25532039" @default.
• W2014767959 hasPublicationYear "2015" @default.
• W2014767959 type Work @default.
• W2014767959 sameAs 2014767959 @default.
• W2014767959 citedByCount "78" @default.
• W2014767959 countsByYear W20147679592015 @default.
• W2014767959 countsByYear W20147679592016 @default.
• W2014767959 countsByYear W20147679592017 @default.
• W2014767959 countsByYear W20147679592018 @default.
• W2014767959 countsByYear W20147679592019 @default.
• W2014767959 countsByYear W20147679592020 @default.
• W2014767959 countsByYear W20147679592021 @default.
• W2014767959 countsByYear W20147679592022 @default.
• W2014767959 countsByYear W20147679592023 @default.
• W2014767959 crossrefType "journal-article" @default.
• W2014767959 hasAuthorship W2014767959A5006152198 @default.
• W2014767959 hasAuthorship W2014767959A5022099945 @default.
• W2014767959 hasAuthorship W2014767959A5033834367 @default.
• W2014767959 hasAuthorship W2014767959A5037897862 @default.
• W2014767959 hasAuthorship W2014767959A5048402117 @default.
• W2014767959 hasAuthorship W2014767959A5055275116 @default.
• W2014767959 hasAuthorship W2014767959A5061585561 @default.
• W2014767959 hasAuthorship W2014767959A5081465085 @default.
• W2014767959 hasBestOaLocation W20147679591 @default.
• W2014767959 hasConcept C104317684 @default.
• W2014767959 hasConcept C105702510 @default.
• W2014767959 hasConcept C126322002 @default.
• W2014767959 hasConcept C127716648 @default.
• W2014767959 hasConcept C134018914 @default.
• W2014767959 hasConcept C2776314099 @default.
• W2014767959 hasConcept C2777391703 @default.
• W2014767959 hasConcept C2780610479 @default.
• W2014767959 hasConcept C35158069 @default.
• W2014767959 hasConcept C41091548 @default.
• W2014767959 hasConcept C54355233 @default.
• W2014767959 hasConcept C555293320 @default.
• W2014767959 hasConcept C71924100 @default.
• W2014767959 hasConcept C86803240 @default.
• W2014767959 hasConceptScore W2014767959C104317684 @default.
• W2014767959 hasConceptScore W2014767959C105702510 @default.
• W2014767959 hasConceptScore W2014767959C126322002 @default.
• W2014767959 hasConceptScore W2014767959C127716648 @default.
• W2014767959 hasConceptScore W2014767959C134018914 @default.
• W2014767959 hasConceptScore W2014767959C2776314099 @default.
• W2014767959 hasConceptScore W2014767959C2777391703 @default.
• W2014767959 hasConceptScore W2014767959C2780610479 @default.
• W2014767959 hasConceptScore W2014767959C35158069 @default.
• W2014767959 hasConceptScore W2014767959C41091548 @default.
• W2014767959 hasConceptScore W2014767959C54355233 @default.
• W2014767959 hasConceptScore W2014767959C555293320 @default.
• W2014767959 hasConceptScore W2014767959C71924100 @default.
• W2014767959 hasConceptScore W2014767959C86803240 @default.
• W2014767959 hasIssue "3" @default.
• W2014767959 hasLocation W20147679591 @default.
• W2014767959 hasLocation W20147679592 @default.
• W2014767959 hasOpenAccess W2014767959 @default.
• W2014767959 hasPrimaryLocation W20147679591 @default.
• W2014767959 hasRelatedWork W1979252938 @default.
• W2014767959 hasRelatedWork W2032225465 @default.
• W2014767959 hasRelatedWork W2169206971 @default.
• W2014767959 hasRelatedWork W2378290744 @default.
• W2014767959 hasRelatedWork W2584731720 @default.
• W2014767959 hasRelatedWork W2886303208 @default.
• W2014767959 hasRelatedWork W2910989958 @default.

• next