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- W2014769282 abstract "1. The effects of thrombin on platelet glycolysis were studied by measuring levels of glycolytic intermediates. Comparisons were made with the effects of inhibition of respiration by cyanide. 2. Glycogen phosphorylase and phosphofructokinase were identified as major regulatory enzymes with both cyanide and thrombin. 3. Activation of both enzymes occurred at the same time with cyanide. With thrombin, activation of phosphorylase was observed sooner (2.5 sec after addition of thrombin) than activation of phosphofructokinase (10 sec after addition of thrombin). 4. The results are interpreted as indicating that thrombin activates phosphofructokinase allosterically by changing the energy charge of the adenine nucleotide pool as a result of increased utilization of ATP, while activation of phosphorylase is by conversion of phosphorylase b to a, probably by a Ca2+-activated phosphorylase kinase." @default.
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- W2014769282 date "1972-02-01" @default.
- W2014769282 modified "2023-09-26" @default.
- W2014769282 title "Control of energy metabolism in platelets. The effects of thrombin and cyanide on glycolysis" @default.
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- W2014769282 doi "https://doi.org/10.1016/0005-2728(72)90049-7" @default.
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