Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014769887> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2014769887 endingPage "35" @default.
- W2014769887 startingPage "30" @default.
- W2014769887 abstract "The short-chain (n approximately equal to 50) homopolymer poly(L-cysteine) (PLC) has been previously studied for use as a novel metal chelator. PLC exhibits reversible oxidation-reduction chemistry involving the thiol groups of the cysteine (Cys) residues. Previously, chemical oxidation of the PLC immobilized on silica showed that metal binding capacity was minimal in the oxidized state. In this study, Cys and PLC are immobilized on a glassy carbon disk electrode (GCE) to study these redox processes and how they impact metal binding and release. Voltammetric and chronoamperometric methods were employed to demonstrate nearly monolayer coverage of both immobilized Cys monomer and immobilized PLC on GCE. The PLC-GCE exhibited a maximum metal binding capacity for Cd2+ of approximately 11 Cd2+ ions/chain. No detectable metal binding capacity was observed for oxidized PLC. The bound metals were capable of being efficiently released through disulfide bond formation and tertiary structure changes by means of repetitive oxidative pulses. The Cys-modified electrode exhibited a metal binding capacity for Cd2+ of approximately 1 Cd2+/Cys. Oxidized Cys did retain a significant capacity following oxidation, likely as a result of complexation with the terminal carboxylate site and unoxidized thiols. A glycine (Gly)-modified electrode was also evaluated as an amino acid control. Minimal Cd2+ binding was observed. Further metal binding studies were conducted using PLC-GCE with single metal solutions of Co2+, Cu2+, Ni2+, and Pb2+, as well as a multimetal solution composed of equal concentrations of all five target metals. The observed metal binding trend was as follows: Cu2+ > Cd2+ > Ni2+ > Pb2+ > Co2+. All metals were quantitatively released upon oxidation of PLC using the same anodic potential, 600 mV vs Ag/AgCl." @default.
- W2014769887 created "2016-06-24" @default.
- W2014769887 creator A5039858494 @default.
- W2014769887 creator A5078222160 @default.
- W2014769887 date "2004-11-19" @default.
- W2014769887 modified "2023-10-16" @default.
- W2014769887 title "Poly(<scp>l</scp>-cysteine) as an Electrochemically Modifiable Ligand for Trace Metal Chelation" @default.
- W2014769887 cites W1976220731 @default.
- W2014769887 cites W2007418961 @default.
- W2014769887 cites W2037197939 @default.
- W2014769887 cites W2042093813 @default.
- W2014769887 cites W2052937239 @default.
- W2014769887 cites W2058776928 @default.
- W2014769887 cites W2059298502 @default.
- W2014769887 cites W2074860692 @default.
- W2014769887 cites W2081406839 @default.
- W2014769887 cites W2087286951 @default.
- W2014769887 cites W2165783435 @default.
- W2014769887 cites W2319342096 @default.
- W2014769887 cites W3004431080 @default.
- W2014769887 doi "https://doi.org/10.1021/ac048875+" @default.
- W2014769887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15623275" @default.
- W2014769887 hasPublicationYear "2004" @default.
- W2014769887 type Work @default.
- W2014769887 sameAs 2014769887 @default.
- W2014769887 citedByCount "30" @default.
- W2014769887 countsByYear W20147698872013 @default.
- W2014769887 countsByYear W20147698872014 @default.
- W2014769887 countsByYear W20147698872015 @default.
- W2014769887 countsByYear W20147698872016 @default.
- W2014769887 countsByYear W20147698872017 @default.
- W2014769887 countsByYear W20147698872018 @default.
- W2014769887 countsByYear W20147698872021 @default.
- W2014769887 countsByYear W20147698872022 @default.
- W2014769887 countsByYear W20147698872023 @default.
- W2014769887 crossrefType "journal-article" @default.
- W2014769887 hasAuthorship W2014769887A5039858494 @default.
- W2014769887 hasAuthorship W2014769887A5078222160 @default.
- W2014769887 hasConcept C116569031 @default.
- W2014769887 hasConcept C13965031 @default.
- W2014769887 hasConcept C147789679 @default.
- W2014769887 hasConcept C170493617 @default.
- W2014769887 hasConcept C17525397 @default.
- W2014769887 hasConcept C178790620 @default.
- W2014769887 hasConcept C179104552 @default.
- W2014769887 hasConcept C181199279 @default.
- W2014769887 hasConcept C185592680 @default.
- W2014769887 hasConcept C197404232 @default.
- W2014769887 hasConcept C199164860 @default.
- W2014769887 hasConcept C2778074193 @default.
- W2014769887 hasConcept C2779201268 @default.
- W2014769887 hasConcept C52859227 @default.
- W2014769887 hasConcept C544153396 @default.
- W2014769887 hasConcept C55493867 @default.
- W2014769887 hasConcept C55904794 @default.
- W2014769887 hasConcept C71240020 @default.
- W2014769887 hasConceptScore W2014769887C116569031 @default.
- W2014769887 hasConceptScore W2014769887C13965031 @default.
- W2014769887 hasConceptScore W2014769887C147789679 @default.
- W2014769887 hasConceptScore W2014769887C170493617 @default.
- W2014769887 hasConceptScore W2014769887C17525397 @default.
- W2014769887 hasConceptScore W2014769887C178790620 @default.
- W2014769887 hasConceptScore W2014769887C179104552 @default.
- W2014769887 hasConceptScore W2014769887C181199279 @default.
- W2014769887 hasConceptScore W2014769887C185592680 @default.
- W2014769887 hasConceptScore W2014769887C197404232 @default.
- W2014769887 hasConceptScore W2014769887C199164860 @default.
- W2014769887 hasConceptScore W2014769887C2778074193 @default.
- W2014769887 hasConceptScore W2014769887C2779201268 @default.
- W2014769887 hasConceptScore W2014769887C52859227 @default.
- W2014769887 hasConceptScore W2014769887C544153396 @default.
- W2014769887 hasConceptScore W2014769887C55493867 @default.
- W2014769887 hasConceptScore W2014769887C55904794 @default.
- W2014769887 hasConceptScore W2014769887C71240020 @default.
- W2014769887 hasIssue "1" @default.
- W2014769887 hasLocation W20147698871 @default.
- W2014769887 hasLocation W20147698872 @default.
- W2014769887 hasOpenAccess W2014769887 @default.
- W2014769887 hasPrimaryLocation W20147698871 @default.
- W2014769887 hasRelatedWork W1966756687 @default.
- W2014769887 hasRelatedWork W2022283669 @default.
- W2014769887 hasRelatedWork W2037971223 @default.
- W2014769887 hasRelatedWork W2053855273 @default.
- W2014769887 hasRelatedWork W2069193002 @default.
- W2014769887 hasRelatedWork W2088914238 @default.
- W2014769887 hasRelatedWork W2125810935 @default.
- W2014769887 hasRelatedWork W2793665360 @default.
- W2014769887 hasRelatedWork W2890812159 @default.
- W2014769887 hasRelatedWork W2582906986 @default.
- W2014769887 hasVolume "77" @default.
- W2014769887 isParatext "false" @default.
- W2014769887 isRetracted "false" @default.
- W2014769887 magId "2014769887" @default.
- W2014769887 workType "article" @default.