Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014770229> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2014770229 abstract "Detailed sex differences in the disposition and metabolism of BOF-4272, a newly developed xanthine oxidase/xanthine dehydrogenase inhibitor, are described on the basis of in-vivo studies in rats.In both male and female rats, at all times after oral administration of 14C-labelled BOF-4272, the highest level of radioactivity (except for radioactivity in the gastrointestinal tract) was observed in the liver, then in the kidney. Little radioactivity was detected in other tissues. After oral administration the total 14C concentration profiles in the plasma and kidney were almost identical in male and female rats whereas total 14C concentrations in the liver to 24h were higher in female rats than in males. Levels of BOF-4269 (the sulphide metabolite of BOF-4272) in the contents of the large intestine to 24h after the oral administration of BOF-4272 were higher in female rats than in males. BOF-4269 was the main metabolite found in the plasma in female rats after intravenous or oral administration. The area under the plasma concentration-time curve (AUC0-t) for BOF-4272 after oral administration was almost identical in female and male rats, whereas that for BOF-4269 was 2.8 times higher in female rats than in males.These findings suggest that differences between the disposition of 14C-labelled BOF-4272 in rats of different sexes are mainly because of differences between the metabolism of BOF-4272 to BOF-4269 by the intestinal flora, the elimination of BOF-4269 by the liver, or both." @default.
- W2014770229 created "2016-06-24" @default.
- W2014770229 creator A5015690383 @default.
- W2014770229 creator A5025692399 @default.
- W2014770229 creator A5034689531 @default.
- W2014770229 creator A5041801530 @default.
- W2014770229 creator A5067192714 @default.
- W2014770229 creator A5075713189 @default.
- W2014770229 creator A5089408950 @default.
- W2014770229 date "2000-04-01" @default.
- W2014770229 modified "2023-09-27" @default.
- W2014770229 title "In-vivo Sex Differences in Disposition and Metabolism of Sulphoxide-containing Drug BOF-4272 in Rats" @default.
- W2014770229 doi "https://doi.org/10.1211/146080800128735854" @default.
- W2014770229 hasPublicationYear "2000" @default.
- W2014770229 type Work @default.
- W2014770229 sameAs 2014770229 @default.
- W2014770229 citedByCount "0" @default.
- W2014770229 crossrefType "journal-article" @default.
- W2014770229 hasAuthorship W2014770229A5015690383 @default.
- W2014770229 hasAuthorship W2014770229A5025692399 @default.
- W2014770229 hasAuthorship W2014770229A5034689531 @default.
- W2014770229 hasAuthorship W2014770229A5041801530 @default.
- W2014770229 hasAuthorship W2014770229A5067192714 @default.
- W2014770229 hasAuthorship W2014770229A5075713189 @default.
- W2014770229 hasAuthorship W2014770229A5089408950 @default.
- W2014770229 hasConcept C112705442 @default.
- W2014770229 hasConcept C126322002 @default.
- W2014770229 hasConcept C134018914 @default.
- W2014770229 hasConcept C150903083 @default.
- W2014770229 hasConcept C185592680 @default.
- W2014770229 hasConcept C207001950 @default.
- W2014770229 hasConcept C2777056448 @default.
- W2014770229 hasConcept C2777477808 @default.
- W2014770229 hasConcept C62231903 @default.
- W2014770229 hasConcept C71924100 @default.
- W2014770229 hasConcept C86803240 @default.
- W2014770229 hasConcept C98274493 @default.
- W2014770229 hasConceptScore W2014770229C112705442 @default.
- W2014770229 hasConceptScore W2014770229C126322002 @default.
- W2014770229 hasConceptScore W2014770229C134018914 @default.
- W2014770229 hasConceptScore W2014770229C150903083 @default.
- W2014770229 hasConceptScore W2014770229C185592680 @default.
- W2014770229 hasConceptScore W2014770229C207001950 @default.
- W2014770229 hasConceptScore W2014770229C2777056448 @default.
- W2014770229 hasConceptScore W2014770229C2777477808 @default.
- W2014770229 hasConceptScore W2014770229C62231903 @default.
- W2014770229 hasConceptScore W2014770229C71924100 @default.
- W2014770229 hasConceptScore W2014770229C86803240 @default.
- W2014770229 hasConceptScore W2014770229C98274493 @default.
- W2014770229 hasLocation W20147702291 @default.
- W2014770229 hasOpenAccess W2014770229 @default.
- W2014770229 hasPrimaryLocation W20147702291 @default.
- W2014770229 hasRelatedWork W1585814412 @default.
- W2014770229 hasRelatedWork W1970981908 @default.
- W2014770229 hasRelatedWork W1991991954 @default.
- W2014770229 hasRelatedWork W1998282142 @default.
- W2014770229 hasRelatedWork W2043753038 @default.
- W2014770229 hasRelatedWork W2055637124 @default.
- W2014770229 hasRelatedWork W2085991340 @default.
- W2014770229 hasRelatedWork W2150835916 @default.
- W2014770229 hasRelatedWork W2163709435 @default.
- W2014770229 hasRelatedWork W2164029851 @default.
- W2014770229 hasRelatedWork W2315816963 @default.
- W2014770229 hasRelatedWork W2317147376 @default.
- W2014770229 hasRelatedWork W2318869520 @default.
- W2014770229 hasRelatedWork W2320056037 @default.
- W2014770229 hasRelatedWork W2329046933 @default.
- W2014770229 hasRelatedWork W2329061257 @default.
- W2014770229 hasRelatedWork W2330160438 @default.
- W2014770229 hasRelatedWork W2334661947 @default.
- W2014770229 hasRelatedWork W3209342504 @default.
- W2014770229 hasRelatedWork W1952575721 @default.
- W2014770229 isParatext "false" @default.
- W2014770229 isRetracted "false" @default.
- W2014770229 magId "2014770229" @default.
- W2014770229 workType "article" @default.