FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014770452> ?p ?o ?g. }

• W2014770452 endingPage "1565" @default.
• W2014770452 startingPage "1557" @default.
• W2014770452 abstract "Chronic bone infection, as attends periodontitis, is often complicated by severe osteolysis. While LPS is believed to be central to the pathogenesis of the osteolytic lesion, the mechanisms by which this bacteria-derived molecule promotes bone resorption are unknown. We find that LPS induces bone marrow macrophages (BMMs) to express c-src, a protooncogene product that we demonstrate is a specific marker of commitment to the osteoclast phenotype. We next turned to possible soluble mediators of LPS-induced c-src. Of a number of osteoclastogenic cytokines tested, only TNF-alpha mirrors the c-src-enhancing effect of LPS. Suggesting that LPS augmentation of c-src is TNF-mediated, endotoxin sequentially induces BMM expression of TNF, followed by c-src. TNF and c-src expression, by cultured BMMs derived from LPS-injected mice, reflects duration of exposure to circulating endotoxin, intimating that endotoxin's effect in vivo is also mediated by TNF. Consistent with these findings, thalidomide (which antagonizes TNF action) attenuates c-src induction by LPS. An anti-TNF antibody blocks LPS enhancement of c-src mRNA, validating the cytokine's modulating role in vitro. Using BMMs of TNF receptor-deleted mice, we demonstrate that TNF induction of c-src is transmitted through the cytokine's p55, but not p75, receptor. Most importantly, LPS administered to wild-type mice prompts osteoclast precursor differentiation, manifest by profound osteoclastogenesis in marrow cultured ex vivo, and by a profusion of marrow-residing cells expressing the osteoclast marker tartrate resistant acid phosphatase, in vivo. In contrast, LPS does not substantially enhance osteoclast proliferation in mice lacking the p55TNF receptor, confirming that LPS-induced osteoclastogenesis is mediated by TNF in vivo via this receptor. Thus, therapy targeting TNF and/or its p55 receptor presents itself as a means of preventing the osteolysis of chronic bacterial infection." @default.
• W2014770452 created "2016-06-24" @default.
• W2014770452 creator A5001716316 @default.
• W2014770452 creator A5003330445 @default.
• W2014770452 creator A5040295712 @default.
• W2014770452 creator A5058432635 @default.
• W2014770452 date "1997-09-15" @default.
• W2014770452 modified "2023-10-01" @default.
• W2014770452 title "Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor." @default.
• W2014770452 cites W1483551415 @default.
• W2014770452 cites W1637104594 @default.
• W2014770452 cites W1660489924 @default.
• W2014770452 cites W1822061653 @default.
• W2014770452 cites W1893715971 @default.
• W2014770452 cites W1971544544 @default.
• W2014770452 cites W1972663624 @default.
• W2014770452 cites W1974709212 @default.
• W2014770452 cites W1975587041 @default.
• W2014770452 cites W1984113136 @default.
• W2014770452 cites W1986992784 @default.
• W2014770452 cites W1987059825 @default.
• W2014770452 cites W1988429249 @default.
• W2014770452 cites W1998761125 @default.
• W2014770452 cites W2000170431 @default.
• W2014770452 cites W2004842045 @default.
• W2014770452 cites W2009550948 @default.
• W2014770452 cites W2009934810 @default.
• W2014770452 cites W2017916878 @default.
• W2014770452 cites W2018289835 @default.
• W2014770452 cites W2023240542 @default.
• W2014770452 cites W2023694966 @default.
• W2014770452 cites W2033684266 @default.
• W2014770452 cites W2038478733 @default.
• W2014770452 cites W2043651158 @default.
• W2014770452 cites W2049953991 @default.
• W2014770452 cites W2050828232 @default.
• W2014770452 cites W2067024450 @default.
• W2014770452 cites W2081323226 @default.
• W2014770452 cites W2086255604 @default.
• W2014770452 cites W2090439142 @default.
• W2014770452 cites W2092377971 @default.
• W2014770452 cites W2100837269 @default.
• W2014770452 cites W2126446849 @default.
• W2014770452 cites W2145808389 @default.
• W2014770452 cites W2150571795 @default.
• W2014770452 cites W2156764315 @default.
• W2014770452 cites W2159746652 @default.
• W2014770452 cites W2161175463 @default.
• W2014770452 cites W2166506012 @default.
• W2014770452 cites W2410418488 @default.
• W2014770452 cites W243103330 @default.
• W2014770452 cites W4254958847 @default.
• W2014770452 doi "https://doi.org/10.1172/jci119679" @default.
• W2014770452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/508337" @default.
• W2014770452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9294124" @default.
• W2014770452 hasPublicationYear "1997" @default.
• W2014770452 type Work @default.
• W2014770452 sameAs 2014770452 @default.
• W2014770452 citedByCount "265" @default.
• W2014770452 countsByYear W20147704522012 @default.
• W2014770452 countsByYear W20147704522013 @default.
• W2014770452 countsByYear W20147704522014 @default.
• W2014770452 countsByYear W20147704522015 @default.
• W2014770452 countsByYear W20147704522016 @default.
• W2014770452 countsByYear W20147704522017 @default.
• W2014770452 countsByYear W20147704522018 @default.
• W2014770452 countsByYear W20147704522019 @default.
• W2014770452 countsByYear W20147704522020 @default.
• W2014770452 countsByYear W20147704522021 @default.
• W2014770452 countsByYear W20147704522022 @default.
• W2014770452 countsByYear W20147704522023 @default.
• W2014770452 crossrefType "journal-article" @default.
• W2014770452 hasAuthorship W2014770452A5001716316 @default.
• W2014770452 hasAuthorship W2014770452A5003330445 @default.
• W2014770452 hasAuthorship W2014770452A5040295712 @default.
• W2014770452 hasAuthorship W2014770452A5058432635 @default.
• W2014770452 hasBestOaLocation W20147704521 @default.
• W2014770452 hasConcept C108636557 @default.
• W2014770452 hasConcept C126322002 @default.
• W2014770452 hasConcept C134018914 @default.
• W2014770452 hasConcept C141071460 @default.
• W2014770452 hasConcept C150903083 @default.
• W2014770452 hasConcept C170493617 @default.
• W2014770452 hasConcept C17991360 @default.
• W2014770452 hasConcept C185592680 @default.
• W2014770452 hasConcept C203014093 @default.
• W2014770452 hasConcept C207001950 @default.
• W2014770452 hasConcept C2776033226 @default.
• W2014770452 hasConcept C2778690821 @default.
• W2014770452 hasConcept C2778754761 @default.
• W2014770452 hasConcept C2779428903 @default.
• W2014770452 hasConcept C2780007613 @default.
• W2014770452 hasConcept C2781282405 @default.
• W2014770452 hasConcept C502942594 @default.
• W2014770452 hasConcept C673006 @default.
• W2014770452 hasConcept C71924100 @default.
• W2014770452 hasConcept C86803240 @default.
• W2014770452 hasConcept C88045685 @default.

• next