FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014771353> ?p ?o ?g. }

• W2014771353 endingPage "e82" @default.
• W2014771353 startingPage "e76" @default.
• W2014771353 abstract "Synaptosomal-associated protein of 25 kDa (SNAP25) is a member of the soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) protein complex, which plays essential roles in the modulation of different voltage-gated calcium channels and neurotransmitter release. Many previous studies have reported the SNAP25 gene to be significantly associated with attention-deficit/hyperactivity disorder (ADHD). Recently, shared genetic variants have been demonstrated in 5 major psychiatric disorders, including schizophrenia, major depressive disorder, bipolar disorder, autism spectrum disorders, and ADHD. However, no compelling, convincing evidence has suggested an association between SNAP25 and schizophrenia or major depressive disorder. Thus, we investigated the association between SNAP25 and both schizophrenia and major depressive disorder in the Han Chinese population.We performed a large-scale case-control study to test the association between SNAP25 and 2 major mental disorders, schizophrenia (DSM-IV criteria) and major depressive disorder (DSM-IV criteria), in the Han Chinese population. Seven single-nucleotide polymorphisms (SNPs) were genotyped in 1,330 schizophrenia patients, 1,045 major depressive disorder patients, and 1,520 healthy controls of Han Chinese origin.Two SNPs, rs3787283 and rs3746544, were found to be associated with both schizophrenia (rs3746544, adjusted P = .00257) and major depressive disorder (rs3746544, adjusted P = .0485; rs3787283, adjusted P = .00387) in this study. The AG haplotype consisting of rs3787283 and rs3746544 was also significantly associated with both schizophrenia and major depressive disorder (schizophrenia: adjusted P = .0126; major depressive disorder: adjusted P = .000580). Additionally, we carried out a meta-analysis of the current data and published association results and further confirmed the association between rs3746544 and schizophrenia (Pmeta = .002, ORmeta = 1.213 [95% CI, 1.077-1.367]).Our results indicated that SNPs in SNAP25 represented a common risk factor of both schizophrenia and major depressive disorder in the Han Chinese population." @default.
• W2014771353 created "2016-06-24" @default.
• W2014771353 creator A5004165664 @default.
• W2014771353 creator A5004254273 @default.
• W2014771353 creator A5011241874 @default.
• W2014771353 creator A5021075276 @default.
• W2014771353 creator A5031437856 @default.
• W2014771353 creator A5032617409 @default.
• W2014771353 creator A5040863158 @default.
• W2014771353 creator A5042560788 @default.
• W2014771353 creator A5047134204 @default.
• W2014771353 creator A5059950155 @default.
• W2014771353 creator A5060341807 @default.
• W2014771353 creator A5073897483 @default.
• W2014771353 creator A5080431687 @default.
• W2014771353 creator A5086714131 @default.
• W2014771353 creator A5087423645 @default.
• W2014771353 creator A5090497741 @default.
• W2014771353 date "2015-01-28" @default.
• W2014771353 modified "2023-10-03" @default.
• W2014771353 title "<em>SNAP25<em> Is Associated With Schizophrenia and Major Depressive Disorder in the Han Chinese Population" @default.
• W2014771353 cites W1524110814 @default.
• W2014771353 cites W1963673462 @default.
• W2014771353 cites W1979130304 @default.
• W2014771353 cites W1992847257 @default.
• W2014771353 cites W1993706808 @default.
• W2014771353 cites W1994109896 @default.
• W2014771353 cites W1997576450 @default.
• W2014771353 cites W1999575197 @default.
• W2014771353 cites W2005133671 @default.
• W2014771353 cites W2006878605 @default.
• W2014771353 cites W2019097293 @default.
• W2014771353 cites W2021535444 @default.
• W2014771353 cites W2030447006 @default.
• W2014771353 cites W2032930756 @default.
• W2014771353 cites W2033320712 @default.
• W2014771353 cites W2035192299 @default.
• W2014771353 cites W2042773138 @default.
• W2014771353 cites W2044819723 @default.
• W2014771353 cites W2046013073 @default.
• W2014771353 cites W2046247026 @default.
• W2014771353 cites W2049792617 @default.
• W2014771353 cites W2061712427 @default.
• W2014771353 cites W2065521084 @default.
• W2014771353 cites W2071613912 @default.
• W2014771353 cites W2071880067 @default.
• W2014771353 cites W2078349873 @default.
• W2014771353 cites W2097323670 @default.
• W2014771353 cites W2107973794 @default.
• W2014771353 cites W2109275773 @default.
• W2014771353 cites W2117161714 @default.
• W2014771353 cites W2139852368 @default.
• W2014771353 cites W2140660757 @default.
• W2014771353 cites W2144034070 @default.
• W2014771353 cites W2144963822 @default.
• W2014771353 cites W2149693794 @default.
• W2014771353 cites W2161986875 @default.
• W2014771353 cites W2162530578 @default.
• W2014771353 doi "https://doi.org/10.4088/jcp.13m08962" @default.
• W2014771353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25650683" @default.
• W2014771353 hasPublicationYear "2015" @default.
• W2014771353 type Work @default.
• W2014771353 sameAs 2014771353 @default.
• W2014771353 citedByCount "33" @default.
• W2014771353 countsByYear W20147713532016 @default.
• W2014771353 countsByYear W20147713532017 @default.
• W2014771353 countsByYear W20147713532018 @default.
• W2014771353 countsByYear W20147713532019 @default.
• W2014771353 countsByYear W20147713532020 @default.
• W2014771353 countsByYear W20147713532021 @default.
• W2014771353 countsByYear W20147713532022 @default.
• W2014771353 countsByYear W20147713532023 @default.
• W2014771353 crossrefType "journal-article" @default.
• W2014771353 hasAuthorship W2014771353A5004165664 @default.
• W2014771353 hasAuthorship W2014771353A5004254273 @default.
• W2014771353 hasAuthorship W2014771353A5011241874 @default.
• W2014771353 hasAuthorship W2014771353A5021075276 @default.
• W2014771353 hasAuthorship W2014771353A5031437856 @default.
• W2014771353 hasAuthorship W2014771353A5032617409 @default.
• W2014771353 hasAuthorship W2014771353A5040863158 @default.
• W2014771353 hasAuthorship W2014771353A5042560788 @default.
• W2014771353 hasAuthorship W2014771353A5047134204 @default.
• W2014771353 hasAuthorship W2014771353A5059950155 @default.
• W2014771353 hasAuthorship W2014771353A5060341807 @default.
• W2014771353 hasAuthorship W2014771353A5073897483 @default.
• W2014771353 hasAuthorship W2014771353A5080431687 @default.
• W2014771353 hasAuthorship W2014771353A5086714131 @default.
• W2014771353 hasAuthorship W2014771353A5087423645 @default.
• W2014771353 hasAuthorship W2014771353A5090497741 @default.
• W2014771353 hasConcept C104317684 @default.
• W2014771353 hasConcept C118552586 @default.
• W2014771353 hasConcept C135763542 @default.
• W2014771353 hasConcept C153209595 @default.
• W2014771353 hasConcept C15744967 @default.
• W2014771353 hasConcept C169900460 @default.
• W2014771353 hasConcept C205778803 @default.
• W2014771353 hasConcept C2776174506 @default.
• W2014771353 hasConcept C2776412080 @default.

• next