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- W2014773249 abstract "By using ultra-violet and visible absorbance in conjunction with high field 1H-nuclear magnetic resonance spectroscopy, the insulin hexamer has been shown to undergo two allosteric transitions in solution involving three allosteric states (T6<-->T3 R3<-->R6). A simple mathematical model consisting of four variables has been derived that quantitatively describes the complex homotropic and heterotropic interactions that modulate these allosteric transitions. The mutation of one residue, Glu-B13 to Gln, results in an unexpected change in the T3R3 to R6 equilibrium by a factor of 10(7)." @default.
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- W2014773249 date "1995-01-01" @default.
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- W2014773249 title "Ligand Binding to Wild-type and E-B13Q Mutant Insulins: A Three-state Allosteric Model System Showing Half-site Reactivity" @default.
- W2014773249 doi "https://doi.org/10.1006/jmbi.1994.0027" @default.
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