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• W2014779062 abstract "Abstract Background & Aims Despite the high prevalence of antimicrobial‐resistant Escherichia coli in hospital‐acquired infections, the clinical epidemiology of fluoroquinolone ( FQ ) resistance in community‐onset spontaneous bacterial peritonitis ( SBP ) in patients with cirrhosis is not well understood. This study was performed to evaluate clinical features and risk factors for community‐onset SBP caused by FQ ‐resistant E. coli . Methods A case‐control control study was performed using cases of community‐onset SBP from June 2000 to August 2011 at Samsung Medical Center (Seoul, Korea). Patients with FQ ‐resistant E. coli were designated as case patients. A control group I ( CG I) patient was defined as a person whose clinical sample yielded FQ ‐susceptible E. coli, and a control group II ( CG II ) patient was defined as a person with a negative culture result. Results A total of 82 subjects with community‐onset SBP caused by E. coli were identified, of which 26 (31.7%) were FQ ‐resistant E. coli infection. Fifty‐seven matched subjects were randomly selected for CG II . Compared with CG I, previous SBP episodes ( OR , 4.91; 95% CI , 1.50–16.53; P = 0.010), prior use of FQ within 30 days ( OR , 7.05; 95% CI , 1.17–42.38; P = 0.033), and third‐generation cephalosporin resistance ( OR , 17.68; 95% CI , 1.67–187.26; P = 0.017) were significantly associated with FQ ‐resistant E. coli . Compared with CG II , a previous SBP episode was significantly associated with FQ ‐resistant E. coli ( OR , 4.20; 95% CI , 1.50–11.80; P = 0.006). Conclusion FQ ‐resistant E. coli is a significant cause of community‐onset SBP , with relation to previous SBP episodes, recent FQ use and third‐generation cephalosporin resistance." @default.
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• W2014779062 date "2013-11-24" @default.
• W2014779062 modified "2023-10-17" @default.
• W2014779062 title "Risk factor of community-onset spontaneous bacterial peritonitis caused by fluoroquinolone-resistant Escherichia coli in patients with cirrhosis" @default.
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• W2014779062 doi "https://doi.org/10.1111/liv.12374" @default.
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