Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014785004> ?p ?o ?g. }
- W2014785004 endingPage "11388" @default.
- W2014785004 startingPage "11377" @default.
- W2014785004 abstract "The human SWI/SNF (hSWI/SNF) ATP-dependent chromatin remodeling complex is a tumor suppressor and essential transcriptional coregulator. SWI/SNF complexes have been shown to alter nucleosome positions, and this activity is likely to be important for their functions. However, previous studies have largely been unable to determine the extent to which DNA sequence might control nucleosome repositioning by SWI/SNF complexes. Here, we employ a minicircle remodeling approach to provide the first evidence that hSWI/SNF moves nucleosomes in a sequence dependent manner, away from nucleosome positioning sequences favored during nucleosome assembly. This repositioning is unaffected by the presence of DNA nicks, and can occur on closed-circular DNAs in the absence of topoisomerases. We observed directed nucleosome movement on minicircles derived from the human SWI/SNF-regulated c-myc promoter, which may contribute to the previously observed disruption of two promoter nucleosomes during c-myc activation in vivo. Our results suggest a model wherein hSWI/SNF-directed nucleosome movement away from default positioning sequences results in sequence-specific regulatory effects." @default.
- W2014785004 created "2016-06-24" @default.
- W2014785004 creator A5016239245 @default.
- W2014785004 creator A5023525135 @default.
- W2014785004 creator A5051218801 @default.
- W2014785004 creator A5055310458 @default.
- W2014785004 date "2007-09-18" @default.
- W2014785004 modified "2023-09-27" @default.
- W2014785004 title "Human SWI/SNF Drives Sequence-Directed Repositioning of Nucleosomes on C-myc Promoter DNA Minicircles" @default.
- W2014785004 cites W104820104 @default.
- W2014785004 cites W1573199447 @default.
- W2014785004 cites W1573433765 @default.
- W2014785004 cites W1964689386 @default.
- W2014785004 cites W1965588875 @default.
- W2014785004 cites W1966605181 @default.
- W2014785004 cites W1968700151 @default.
- W2014785004 cites W1973536007 @default.
- W2014785004 cites W1979668925 @default.
- W2014785004 cites W1980971292 @default.
- W2014785004 cites W1981397859 @default.
- W2014785004 cites W1987431581 @default.
- W2014785004 cites W1987435610 @default.
- W2014785004 cites W1987718112 @default.
- W2014785004 cites W1989819265 @default.
- W2014785004 cites W1994924280 @default.
- W2014785004 cites W1996234697 @default.
- W2014785004 cites W1999141348 @default.
- W2014785004 cites W2008878794 @default.
- W2014785004 cites W2020582422 @default.
- W2014785004 cites W2020992585 @default.
- W2014785004 cites W2027652933 @default.
- W2014785004 cites W2029364031 @default.
- W2014785004 cites W2029873987 @default.
- W2014785004 cites W2030851477 @default.
- W2014785004 cites W2038777044 @default.
- W2014785004 cites W2042021221 @default.
- W2014785004 cites W2044385397 @default.
- W2014785004 cites W2045186817 @default.
- W2014785004 cites W2051104214 @default.
- W2014785004 cites W2055698723 @default.
- W2014785004 cites W2059202030 @default.
- W2014785004 cites W2059745208 @default.
- W2014785004 cites W2064114814 @default.
- W2014785004 cites W2072139657 @default.
- W2014785004 cites W2081830518 @default.
- W2014785004 cites W2083679421 @default.
- W2014785004 cites W2097935140 @default.
- W2014785004 cites W2099848412 @default.
- W2014785004 cites W2100239410 @default.
- W2014785004 cites W2104968595 @default.
- W2014785004 cites W2121123025 @default.
- W2014785004 cites W2121155074 @default.
- W2014785004 cites W2127205858 @default.
- W2014785004 cites W2128443344 @default.
- W2014785004 cites W2128569886 @default.
- W2014785004 cites W2144400827 @default.
- W2014785004 cites W214606598 @default.
- W2014785004 cites W2146149293 @default.
- W2014785004 cites W2146689455 @default.
- W2014785004 cites W2151082594 @default.
- W2014785004 cites W2159678021 @default.
- W2014785004 cites W2161225294 @default.
- W2014785004 cites W2162928535 @default.
- W2014785004 cites W2165812194 @default.
- W2014785004 cites W2167110640 @default.
- W2014785004 cites W2173601290 @default.
- W2014785004 cites W2413040338 @default.
- W2014785004 cites W2474065091 @default.
- W2014785004 doi "https://doi.org/10.1021/bi7008823" @default.
- W2014785004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2526049" @default.
- W2014785004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17877373" @default.
- W2014785004 hasPublicationYear "2007" @default.
- W2014785004 type Work @default.
- W2014785004 sameAs 2014785004 @default.
- W2014785004 citedByCount "25" @default.
- W2014785004 countsByYear W20147850042012 @default.
- W2014785004 countsByYear W20147850042013 @default.
- W2014785004 countsByYear W20147850042015 @default.
- W2014785004 countsByYear W20147850042016 @default.
- W2014785004 countsByYear W20147850042017 @default.
- W2014785004 crossrefType "journal-article" @default.
- W2014785004 hasAuthorship W2014785004A5016239245 @default.
- W2014785004 hasAuthorship W2014785004A5023525135 @default.
- W2014785004 hasAuthorship W2014785004A5051218801 @default.
- W2014785004 hasAuthorship W2014785004A5055310458 @default.
- W2014785004 hasBestOaLocation W20147850042 @default.
- W2014785004 hasConcept C104317684 @default.
- W2014785004 hasConcept C111936080 @default.
- W2014785004 hasConcept C14519417 @default.
- W2014785004 hasConcept C166941617 @default.
- W2014785004 hasConcept C167227067 @default.
- W2014785004 hasConcept C54355233 @default.
- W2014785004 hasConcept C55204905 @default.
- W2014785004 hasConcept C552990157 @default.
- W2014785004 hasConcept C83640560 @default.
- W2014785004 hasConcept C84772758 @default.
- W2014785004 hasConcept C86339819 @default.
- W2014785004 hasConcept C86803240 @default.