Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014793428> ?p ?o ?g. }
- W2014793428 endingPage "e9749" @default.
- W2014793428 startingPage "e9749" @default.
- W2014793428 abstract "Background Hepatocellular carcinoma (HCC) is characterized by late detection and fast progression, and it is believed that epigenetic disruption may be the cause of its molecular and clinicopathological heterogeneity. A better understanding of the global deregulation of methylation states and how they correlate with disease progression will aid in the design of strategies for earlier detection and better therapeutic decisions. Methods and Findings We characterized the changes in promoter methylation in a series of 30 HCC tumors and their respective surrounding tissue and identified methylation signatures associated with major risk factors and clinical correlates. A wide panel of cancer-related gene promoters was analyzed using Illumina bead array technology, and CpG sites were then selected according to their ability to classify clinicopathological parameters. An independent series of HCC tumors and matched surrounding tissue was used for validation of the signatures. We were able to develop and validate a signature of methylation in HCC. This signature distinguished HCC from surrounding tissue and from other tumor types, and was independent of risk factors. However, aberrant methylation of an independent subset of promoters was associated with tumor progression and etiological risk factors (HBV or HCV infection and alcohol consumption). Interestingly, distinct methylation of an independent panel of gene promoters was strongly correlated with survival after cancer therapy. Conclusion Our study shows that HCC tumors exhibit specific DNA methylation signatures associated with major risk factors and tumor progression stage, with potential clinical applications in diagnosis and prognosis." @default.
- W2014793428 created "2016-06-24" @default.
- W2014793428 creator A5023956790 @default.
- W2014793428 creator A5033294492 @default.
- W2014793428 creator A5036186914 @default.
- W2014793428 creator A5050480535 @default.
- W2014793428 creator A5057093670 @default.
- W2014793428 creator A5083815533 @default.
- W2014793428 creator A5088319064 @default.
- W2014793428 creator A5090875081 @default.
- W2014793428 date "2010-03-17" @default.
- W2014793428 modified "2023-10-18" @default.
- W2014793428 title "Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical Predictors" @default.
- W2014793428 cites W1504303645 @default.
- W2014793428 cites W1537112530 @default.
- W2014793428 cites W1579447084 @default.
- W2014793428 cites W1886848895 @default.
- W2014793428 cites W1966701961 @default.
- W2014793428 cites W1971278063 @default.
- W2014793428 cites W1985575613 @default.
- W2014793428 cites W1985887200 @default.
- W2014793428 cites W1989557556 @default.
- W2014793428 cites W1998516698 @default.
- W2014793428 cites W1999928502 @default.
- W2014793428 cites W2000940387 @default.
- W2014793428 cites W2003203989 @default.
- W2014793428 cites W2009671859 @default.
- W2014793428 cites W2010073727 @default.
- W2014793428 cites W2010829584 @default.
- W2014793428 cites W2015314925 @default.
- W2014793428 cites W2027229185 @default.
- W2014793428 cites W2039634280 @default.
- W2014793428 cites W2043235003 @default.
- W2014793428 cites W2046980861 @default.
- W2014793428 cites W2059109143 @default.
- W2014793428 cites W2074137258 @default.
- W2014793428 cites W2085023377 @default.
- W2014793428 cites W2086035953 @default.
- W2014793428 cites W2088714429 @default.
- W2014793428 cites W2090899401 @default.
- W2014793428 cites W2103099248 @default.
- W2014793428 cites W2104193042 @default.
- W2014793428 cites W2111604012 @default.
- W2014793428 cites W2114973741 @default.
- W2014793428 cites W2115556288 @default.
- W2014793428 cites W2116815663 @default.
- W2014793428 cites W2125313689 @default.
- W2014793428 cites W2127248987 @default.
- W2014793428 cites W2135231304 @default.
- W2014793428 cites W2137476312 @default.
- W2014793428 cites W2138550913 @default.
- W2014793428 cites W2138859400 @default.
- W2014793428 cites W2148405421 @default.
- W2014793428 cites W2150414518 @default.
- W2014793428 cites W2158677075 @default.
- W2014793428 cites W2169385554 @default.
- W2014793428 cites W2170330778 @default.
- W2014793428 doi "https://doi.org/10.1371/journal.pone.0009749" @default.
- W2014793428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2840036" @default.
- W2014793428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20305825" @default.
- W2014793428 hasPublicationYear "2010" @default.
- W2014793428 type Work @default.
- W2014793428 sameAs 2014793428 @default.
- W2014793428 citedByCount "174" @default.
- W2014793428 countsByYear W20147934282012 @default.
- W2014793428 countsByYear W20147934282013 @default.
- W2014793428 countsByYear W20147934282014 @default.
- W2014793428 countsByYear W20147934282015 @default.
- W2014793428 countsByYear W20147934282016 @default.
- W2014793428 countsByYear W20147934282017 @default.
- W2014793428 countsByYear W20147934282018 @default.
- W2014793428 countsByYear W20147934282019 @default.
- W2014793428 countsByYear W20147934282020 @default.
- W2014793428 countsByYear W20147934282021 @default.
- W2014793428 countsByYear W20147934282022 @default.
- W2014793428 countsByYear W20147934282023 @default.
- W2014793428 crossrefType "journal-article" @default.
- W2014793428 hasAuthorship W2014793428A5023956790 @default.
- W2014793428 hasAuthorship W2014793428A5033294492 @default.
- W2014793428 hasAuthorship W2014793428A5036186914 @default.
- W2014793428 hasAuthorship W2014793428A5050480535 @default.
- W2014793428 hasAuthorship W2014793428A5057093670 @default.
- W2014793428 hasAuthorship W2014793428A5083815533 @default.
- W2014793428 hasAuthorship W2014793428A5088319064 @default.
- W2014793428 hasAuthorship W2014793428A5090875081 @default.
- W2014793428 hasBestOaLocation W20147934281 @default.
- W2014793428 hasConcept C101762097 @default.
- W2014793428 hasConcept C104317684 @default.
- W2014793428 hasConcept C121608353 @default.
- W2014793428 hasConcept C140173407 @default.
- W2014793428 hasConcept C143998085 @default.
- W2014793428 hasConcept C150194340 @default.
- W2014793428 hasConcept C190727270 @default.
- W2014793428 hasConcept C2778019345 @default.
- W2014793428 hasConcept C2779256057 @default.
- W2014793428 hasConcept C33288867 @default.
- W2014793428 hasConcept C41091548 @default.
- W2014793428 hasConcept C502942594 @default.