Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014795466> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2014795466 endingPage "115" @default.
- W2014795466 startingPage "111" @default.
- W2014795466 abstract "Contraction of vascular smooth muscle such as that existing in coronary arteries is regulated in part by Ca++ entry into cells via Ca++ channels. Volatile anaesthetics are known to attenuate agonist-induced coronary artery constriction. The purpose of this experiment was to determine if 1.5 MAC concentrations of halothane or enflurane attenuated contractions evoked by activation of one type of Ca++ channel —the potential operator channel. In the current experiment, potential operator channels were activated by depolarizing isolated canine coronary artery rings with high concentration of K+, causing Ca++ entry and vessel contraction. Rings without endothelium were suspended for isometric force measurement in organ chambers containing aerated Krebs-Ringer solution. Maximum response to Ca++ in rings depolarized with K+ was 120 ±5 per cent in untreated versus 101 ±3 per cent in rings treated with enflurane (P < 0.01). The maximum response was 123 ±6 per cent in untreated versus 111 ±5 per cent during halothane administration (P < 0.05). In contrast, nifedipine 10−9 M depressed maximum contractions from 114 ±5 per cent to 37 ±4 per cent (P < 0.01) and nifedipine 10−8 M depressed contractions to 30 ±4 per cent (P < 0.01). In a further series of experiments, sustained contractions were depressed by continued administration of the anaesthetics, indicating no loss of anaesthetic effect with time. The results indicate that 1.5 MAC halothane and enflurane attenuate contractions of canine coronary arteries evoked by depolarization and Ca++ entry through potential operated channels. However, neither halothane nor enflurane exhibited the marked depressant effect exerted by nifedipine." @default.
- W2014795466 created "2016-06-24" @default.
- W2014795466 creator A5004469273 @default.
- W2014795466 creator A5019949513 @default.
- W2014795466 creator A5063361765 @default.
- W2014795466 creator A5068749205 @default.
- W2014795466 creator A5089464167 @default.
- W2014795466 date "1991-01-01" @default.
- W2014795466 modified "2023-10-06" @default.
- W2014795466 title "Attenuation of contraction of isolated canine coronary arteries by enflurane and halothane" @default.
- W2014795466 cites W1875475552 @default.
- W2014795466 cites W1963699687 @default.
- W2014795466 cites W1977197035 @default.
- W2014795466 cites W2009960812 @default.
- W2014795466 cites W2013097801 @default.
- W2014795466 cites W2026325123 @default.
- W2014795466 cites W2030888154 @default.
- W2014795466 cites W2068573903 @default.
- W2014795466 cites W2079305547 @default.
- W2014795466 cites W2080010271 @default.
- W2014795466 cites W2084769286 @default.
- W2014795466 cites W2115508204 @default.
- W2014795466 cites W2136479710 @default.
- W2014795466 cites W2143331422 @default.
- W2014795466 cites W2154902768 @default.
- W2014795466 cites W2157612987 @default.
- W2014795466 cites W2157963933 @default.
- W2014795466 cites W2180403979 @default.
- W2014795466 cites W2406584781 @default.
- W2014795466 cites W2750466703 @default.
- W2014795466 doi "https://doi.org/10.1007/bf03009173" @default.
- W2014795466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1846568" @default.
- W2014795466 hasPublicationYear "1991" @default.
- W2014795466 type Work @default.
- W2014795466 sameAs 2014795466 @default.
- W2014795466 citedByCount "10" @default.
- W2014795466 crossrefType "journal-article" @default.
- W2014795466 hasAuthorship W2014795466A5004469273 @default.
- W2014795466 hasAuthorship W2014795466A5019949513 @default.
- W2014795466 hasAuthorship W2014795466A5063361765 @default.
- W2014795466 hasAuthorship W2014795466A5068749205 @default.
- W2014795466 hasAuthorship W2014795466A5089464167 @default.
- W2014795466 hasBestOaLocation W20147954661 @default.
- W2014795466 hasConcept C103486182 @default.
- W2014795466 hasConcept C126322002 @default.
- W2014795466 hasConcept C163415756 @default.
- W2014795466 hasConcept C185592680 @default.
- W2014795466 hasConcept C2776820930 @default.
- W2014795466 hasConcept C2776932660 @default.
- W2014795466 hasConcept C2777858289 @default.
- W2014795466 hasConcept C2778742706 @default.
- W2014795466 hasConcept C2779066535 @default.
- W2014795466 hasConcept C4141045 @default.
- W2014795466 hasConcept C42219234 @default.
- W2014795466 hasConcept C519063684 @default.
- W2014795466 hasConcept C71924100 @default.
- W2014795466 hasConceptScore W2014795466C103486182 @default.
- W2014795466 hasConceptScore W2014795466C126322002 @default.
- W2014795466 hasConceptScore W2014795466C163415756 @default.
- W2014795466 hasConceptScore W2014795466C185592680 @default.
- W2014795466 hasConceptScore W2014795466C2776820930 @default.
- W2014795466 hasConceptScore W2014795466C2776932660 @default.
- W2014795466 hasConceptScore W2014795466C2777858289 @default.
- W2014795466 hasConceptScore W2014795466C2778742706 @default.
- W2014795466 hasConceptScore W2014795466C2779066535 @default.
- W2014795466 hasConceptScore W2014795466C4141045 @default.
- W2014795466 hasConceptScore W2014795466C42219234 @default.
- W2014795466 hasConceptScore W2014795466C519063684 @default.
- W2014795466 hasConceptScore W2014795466C71924100 @default.
- W2014795466 hasIssue "1" @default.
- W2014795466 hasLocation W20147954661 @default.
- W2014795466 hasLocation W20147954662 @default.
- W2014795466 hasOpenAccess W2014795466 @default.
- W2014795466 hasPrimaryLocation W20147954661 @default.
- W2014795466 hasRelatedWork W2014795466 @default.
- W2014795466 hasRelatedWork W2016334212 @default.
- W2014795466 hasRelatedWork W2028905654 @default.
- W2014795466 hasRelatedWork W2029964109 @default.
- W2014795466 hasRelatedWork W2033565399 @default.
- W2014795466 hasRelatedWork W2044191573 @default.
- W2014795466 hasRelatedWork W2090778935 @default.
- W2014795466 hasRelatedWork W2117973200 @default.
- W2014795466 hasRelatedWork W2160286434 @default.
- W2014795466 hasRelatedWork W2412406166 @default.
- W2014795466 hasVolume "38" @default.
- W2014795466 isParatext "false" @default.
- W2014795466 isRetracted "false" @default.
- W2014795466 magId "2014795466" @default.
- W2014795466 workType "article" @default.