FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014795912> ?p ?o ?g. }

• W2014795912 endingPage "22" @default.
• W2014795912 startingPage "11" @default.
• W2014795912 abstract "This study investigated the in vivo metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP) in rats after multiple dosing, the metabolism of MEHP in primary rat hepatocyte cultures for periods of up to 3 days, and the biotransformation of some major metabolites of MEHP. Rats were orally administered [14C]DEHP or [14C]MEHP at doses of 50 and 500 mg/kg body wt for three consecutive days. Urine was collected at 24-hr intervals, and metabolite profiles were determined. After a single dose of either compound, urinary metabolite profiles were similar to those previously reported. However, after multiple administration of both DEHP and MEHP at 500 mg/kg, increases in omega-/beta-oxidation products [metabolites I and V, mono(3-carboxy-2-ethylpropyl) phthalate and mono(5-carboxy-2-ethylpentyl) phthalate, respectively] and decreases in omega - 1-oxidation products [metabolites VI and IX, mono(2-ethyl-5-oxohexyl) phthalate and mono(2-ethyl-5-hydroxyhexyl) phthalate, respectively] were seen. At the low dose of 50 mg/kg little or no alteration in urinary metabolite profiles was observed. At 500 mg/kg of MEHP a 4-fold stimulation of CN- -insensitive palmitoyl-CoA oxidation (a peroxisomal beta-oxidation marker) was seen after three consecutive daily doses. At the low dose of 50 mg/kg only a 1.8-fold increase was noted. Similar observations were made with rat hepatocyte cultures. MEHP at concentrations of 50 and 500 microM was extensively metabolized in the rat hepatocyte cultures. Similar metabolic profiles to those seen after in vivo administration of MEHP were observed. At the high (500 microM) concentration of MEHP, changes in the relative proportions of omega- and omega- 1-oxidized metabolites were seen. Over the 3-day experimental period, omega-/beta-oxidation products increased in a time-dependent manner at the expense of omega - 1-oxidation products. At a concentration of 500 microM MEHP, a 12-fold increase of CN- -insensitive palmitoyl CoA oxidation (a peroxisomal beta-oxidation marker) was observed. At the low concentration of MEHP (50 microM) only a 3-fold increase in CN- -insensitive palmitoyl-CoA oxidation was noted and little alteration in the metabolite profile of MEHP was observed with time. Biotransformation studies of the metabolites of MEHP confirmed the postulated metabolic pathways. Metabolites I and VI appeared to be endpoints of metabolism, while metabolite V was converted to metabolite I, and metabolite IX to metabolite VI. It was also possible to reduce the transformation of metabolite X [mono(2-ethyl-6-hydroxyhexyl) phthalate] to metabolite V.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2014795912 created "2016-06-24" @default.
• W2014795912 creator A5004672953 @default.
• W2014795912 creator A5007314439 @default.
• W2014795912 creator A5011851211 @default.
• W2014795912 creator A5083510264 @default.
• W2014795912 creator A5090378118 @default.
• W2014795912 date "1985-08-01" @default.
• W2014795912 modified "2023-09-25" @default.
• W2014795912 title "The metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) in rats: In vivo and in vitro dose and time dependency of metabolism" @default.
• W2014795912 cites W1503187067 @default.
• W2014795912 cites W164210116 @default.
• W2014795912 cites W1775749144 @default.
• W2014795912 cites W178649100 @default.
• W2014795912 cites W1902962414 @default.
• W2014795912 cites W1977733074 @default.
• W2014795912 cites W1981363323 @default.
• W2014795912 cites W1988351606 @default.
• W2014795912 cites W1988565626 @default.
• W2014795912 cites W1992295823 @default.
• W2014795912 cites W1996520281 @default.
• W2014795912 cites W2021657137 @default.
• W2014795912 cites W2033108939 @default.
• W2014795912 cites W2039676442 @default.
• W2014795912 cites W2040393890 @default.
• W2014795912 cites W2040918147 @default.
• W2014795912 cites W2052874387 @default.
• W2014795912 cites W2059785305 @default.
• W2014795912 cites W2063580467 @default.
• W2014795912 cites W2067552975 @default.
• W2014795912 cites W2079270466 @default.
• W2014795912 cites W2087432176 @default.
• W2014795912 cites W2092122739 @default.
• W2014795912 cites W2145885671 @default.
• W2014795912 doi "https://doi.org/10.1016/0041-008x(85)90096-1" @default.
• W2014795912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4024100" @default.
• W2014795912 hasPublicationYear "1985" @default.
• W2014795912 type Work @default.
• W2014795912 sameAs 2014795912 @default.
• W2014795912 citedByCount "54" @default.
• W2014795912 countsByYear W20147959122012 @default.
• W2014795912 countsByYear W20147959122013 @default.
• W2014795912 countsByYear W20147959122015 @default.
• W2014795912 countsByYear W20147959122016 @default.
• W2014795912 countsByYear W20147959122017 @default.
• W2014795912 countsByYear W20147959122019 @default.
• W2014795912 countsByYear W20147959122020 @default.
• W2014795912 countsByYear W20147959122021 @default.
• W2014795912 crossrefType "journal-article" @default.
• W2014795912 hasAuthorship W2014795912A5004672953 @default.
• W2014795912 hasAuthorship W2014795912A5007314439 @default.
• W2014795912 hasAuthorship W2014795912A5011851211 @default.
• W2014795912 hasAuthorship W2014795912A5083510264 @default.
• W2014795912 hasAuthorship W2014795912A5090378118 @default.
• W2014795912 hasConcept C112705442 @default.
• W2014795912 hasConcept C126322002 @default.
• W2014795912 hasConcept C134018914 @default.
• W2014795912 hasConcept C150903083 @default.
• W2014795912 hasConcept C178790620 @default.
• W2014795912 hasConcept C185592680 @default.
• W2014795912 hasConcept C195289149 @default.
• W2014795912 hasConcept C202751555 @default.
• W2014795912 hasConcept C207001950 @default.
• W2014795912 hasConcept C2776200302 @default.
• W2014795912 hasConcept C2777414220 @default.
• W2014795912 hasConcept C2777477808 @default.
• W2014795912 hasConcept C2780026642 @default.
• W2014795912 hasConcept C2781005124 @default.
• W2014795912 hasConcept C55493867 @default.
• W2014795912 hasConcept C62231903 @default.
• W2014795912 hasConcept C71924100 @default.
• W2014795912 hasConcept C86803240 @default.
• W2014795912 hasConceptScore W2014795912C112705442 @default.
• W2014795912 hasConceptScore W2014795912C126322002 @default.
• W2014795912 hasConceptScore W2014795912C134018914 @default.
• W2014795912 hasConceptScore W2014795912C150903083 @default.
• W2014795912 hasConceptScore W2014795912C178790620 @default.
• W2014795912 hasConceptScore W2014795912C185592680 @default.
• W2014795912 hasConceptScore W2014795912C195289149 @default.
• W2014795912 hasConceptScore W2014795912C202751555 @default.
• W2014795912 hasConceptScore W2014795912C207001950 @default.
• W2014795912 hasConceptScore W2014795912C2776200302 @default.
• W2014795912 hasConceptScore W2014795912C2777414220 @default.
• W2014795912 hasConceptScore W2014795912C2777477808 @default.
• W2014795912 hasConceptScore W2014795912C2780026642 @default.
• W2014795912 hasConceptScore W2014795912C2781005124 @default.
• W2014795912 hasConceptScore W2014795912C55493867 @default.
• W2014795912 hasConceptScore W2014795912C62231903 @default.
• W2014795912 hasConceptScore W2014795912C71924100 @default.
• W2014795912 hasConceptScore W2014795912C86803240 @default.
• W2014795912 hasIssue "1" @default.
• W2014795912 hasLocation W20147959121 @default.
• W2014795912 hasLocation W20147959122 @default.
• W2014795912 hasOpenAccess W2014795912 @default.
• W2014795912 hasPrimaryLocation W20147959121 @default.
• W2014795912 hasRelatedWork W1966304562 @default.
• W2014795912 hasRelatedWork W1973102900 @default.
• W2014795912 hasRelatedWork W2014795912 @default.

• next