Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014798293> ?p ?o ?g. }
- W2014798293 endingPage "168" @default.
- W2014798293 startingPage "157" @default.
- W2014798293 abstract "Abstract Epithelial‐mesenchymal transition (EMT), characterized by cadherin switching, contributes to cancer metastasis. Our recent study showed that Id‐1 (inhibitor of differentiation‐1) promotes metastasis in esophageal cancer cells, but whether the invasive and metastatic dynamics can be induced early in the carcinogenesis process is still unclear. Immortalization is regarded as the initial stage in the malignant transformation of normal cells. In this study, we investigated the role and mechanisms of Id‐1 in inducing EMT and cell invasiveness in immortalized esophageal epithelial cells. We found that immortalized epithelial cells expressed higher endogenous levels of Id‐1 compared with normal cells. Ectopic Id‐1 expression inhibited the differentiation of immortalized esophageal epithelial cells and promoted cadherin switching, which was accompanied by increased adhesiveness to extracellular matrix, cell motility, migratory potential and matrix metalloproteinase‐dependent invasiveness. GTPase activity assays showed that over‐expression or short‐hairpin RNA knockdown of Id‐1 led to corresponding changes in Rac1 activity, whereas RhoA activity was significantly decreased with Id‐1 depletion. Inhibitors targeting Rac1, RhoA, and Rho kinase suppressed the invasiveness of Id‐1‐expressing NE2‐hTERT cells. Knockdown of N‐cadherin in Id‐1‐over‐expressing cells inhibited cell invasiveness and down‐regulated RhoA activity. These data suggest that the Id‐1‐induced invasive potential may be regulated through the N‐cadherin‐RhoA axis and Rac1 activation. J. Cell. Biochem. 112: 157–168, 2011. © 2010 Wiley‐Liss, Inc." @default.
- W2014798293 created "2016-06-24" @default.
- W2014798293 creator A5030534629 @default.
- W2014798293 creator A5076910312 @default.
- W2014798293 creator A5086159719 @default.
- W2014798293 creator A5087557207 @default.
- W2014798293 date "2011-01-01" @default.
- W2014798293 modified "2023-10-17" @default.
- W2014798293 title "Id-1 induces cell invasiveness in immortalized epithelial cells by regulating cadherin switching and Rho GTPases" @default.
- W2014798293 cites W1647809223 @default.
- W2014798293 cites W1969292950 @default.
- W2014798293 cites W1971873096 @default.
- W2014798293 cites W1973140591 @default.
- W2014798293 cites W1976390050 @default.
- W2014798293 cites W1977321706 @default.
- W2014798293 cites W1989273528 @default.
- W2014798293 cites W1991227171 @default.
- W2014798293 cites W2005247755 @default.
- W2014798293 cites W2006433536 @default.
- W2014798293 cites W2007660746 @default.
- W2014798293 cites W2013347022 @default.
- W2014798293 cites W2014691022 @default.
- W2014798293 cites W2015458324 @default.
- W2014798293 cites W2018725942 @default.
- W2014798293 cites W2028627530 @default.
- W2014798293 cites W2030610316 @default.
- W2014798293 cites W2037249963 @default.
- W2014798293 cites W2041783360 @default.
- W2014798293 cites W2047004875 @default.
- W2014798293 cites W2052626837 @default.
- W2014798293 cites W2058308851 @default.
- W2014798293 cites W2064450320 @default.
- W2014798293 cites W2069839886 @default.
- W2014798293 cites W2073052482 @default.
- W2014798293 cites W2074078019 @default.
- W2014798293 cites W2080746789 @default.
- W2014798293 cites W2082833890 @default.
- W2014798293 cites W2083543572 @default.
- W2014798293 cites W2087868443 @default.
- W2014798293 cites W2091646587 @default.
- W2014798293 cites W2093226717 @default.
- W2014798293 cites W2096791952 @default.
- W2014798293 cites W2102411854 @default.
- W2014798293 cites W2106454275 @default.
- W2014798293 cites W2106995657 @default.
- W2014798293 cites W2118650242 @default.
- W2014798293 cites W2121079321 @default.
- W2014798293 cites W2122349103 @default.
- W2014798293 cites W2126022125 @default.
- W2014798293 cites W2128752526 @default.
- W2014798293 cites W2131326834 @default.
- W2014798293 cites W2136369251 @default.
- W2014798293 cites W2139647802 @default.
- W2014798293 cites W2143826978 @default.
- W2014798293 cites W2159511823 @default.
- W2014798293 cites W2169515379 @default.
- W2014798293 cites W262455939 @default.
- W2014798293 cites W4211224216 @default.
- W2014798293 doi "https://doi.org/10.1002/jcb.22911" @default.
- W2014798293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21053361" @default.
- W2014798293 hasPublicationYear "2011" @default.
- W2014798293 type Work @default.
- W2014798293 sameAs 2014798293 @default.
- W2014798293 citedByCount "19" @default.
- W2014798293 countsByYear W20147982932013 @default.
- W2014798293 countsByYear W20147982932014 @default.
- W2014798293 countsByYear W20147982932015 @default.
- W2014798293 countsByYear W20147982932017 @default.
- W2014798293 countsByYear W20147982932020 @default.
- W2014798293 countsByYear W20147982932022 @default.
- W2014798293 crossrefType "journal-article" @default.
- W2014798293 hasAuthorship W2014798293A5030534629 @default.
- W2014798293 hasAuthorship W2014798293A5076910312 @default.
- W2014798293 hasAuthorship W2014798293A5086159719 @default.
- W2014798293 hasAuthorship W2014798293A5087557207 @default.
- W2014798293 hasBestOaLocation W20147982931 @default.
- W2014798293 hasConcept C121608353 @default.
- W2014798293 hasConcept C137738243 @default.
- W2014798293 hasConcept C1491633281 @default.
- W2014798293 hasConcept C149402561 @default.
- W2014798293 hasConcept C173396325 @default.
- W2014798293 hasConcept C185592680 @default.
- W2014798293 hasConcept C190232843 @default.
- W2014798293 hasConcept C207332259 @default.
- W2014798293 hasConcept C2777093181 @default.
- W2014798293 hasConcept C2779013556 @default.
- W2014798293 hasConcept C2779717556 @default.
- W2014798293 hasConcept C502942594 @default.
- W2014798293 hasConcept C54355233 @default.
- W2014798293 hasConcept C55493867 @default.
- W2014798293 hasConcept C555283112 @default.
- W2014798293 hasConcept C62478195 @default.
- W2014798293 hasConcept C76419328 @default.
- W2014798293 hasConcept C81885089 @default.
- W2014798293 hasConcept C86803240 @default.
- W2014798293 hasConcept C95444343 @default.
- W2014798293 hasConcept C97037327 @default.
- W2014798293 hasConceptScore W2014798293C121608353 @default.