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- W2014803071 abstract "RATIONALE: Allergen-immunotherapy is associated with increases in serum allergen-specific IgG4 and increases in serum inhibitory activity for allergen-IgE binding to B cells (Wachholz P. JACI 2003). We measured the time-course of these variables during withdrawal of IT. METHODS: Thirteen patients who had received IT for 2 years were randomised into two groups. In a double-blind withdrawal, 7 continued on active treatment and 6 received placebo injections for a further two years. Sera were obtained 6-monthly and analysed for allergen (Phleum pratense) specific IgG4 (ELISA) and inhibition of allergen-IgE binding (flow cytometry). RESULTS: After 2 years IT, IgG4 levels were increased compared to baseline (mean ± SD) (pre-IT: 2.96±2.68 IU/ml; post-IT: 64.4±44.6 IU/ml; p=0.001). In subjects that continued IT, IgG4 levels remained consistently high for 2 years. In contrast, withdrawal of IT resulted in a significant decrease in IgG4 levels within 12 months (active: 71.2±35.0 IU/ml; withdrawal: 16.8±12.5 IU/ml; p=0.01) and IgG4 levels remained persistently lower for two years following withdrawal. After 2 years IT, there was also a marked increase in serum IgG inhibitory activity. In both the withdrawal- and the continued-immunotherapy groups, both symptomatic improvement and serum inhibitory activity remained high, with no difference between the groups for two years. CONCLUSIONS: Withdrawal of successful immunotherapy resulted in a reduction in allergen-specific IgG4 within 6 months whereas symptomatic improvement and serum inhibitory activity for allergen-IgE binding to B cells remained high for at least 2 years. This ‘functional’ assay of IgG activity may be more predictive of the clinical response to immunotherapy than IgG4." @default.
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- W2014803071 date "2005-02-01" @default.
- W2014803071 modified "2023-09-27" @default.
- W2014803071 title "Time-course of serum IgG4 levels and IgG inhibitory activity following withdrawal of grass pollen immunotherapy (IT)" @default.
- W2014803071 doi "https://doi.org/10.1016/j.jaci.2004.12.1068" @default.
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