FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014804312> ?p ?o ?g. }

• W2014804312 endingPage "2720" @default.
• W2014804312 startingPage "2713" @default.
• W2014804312 abstract "Highly selective serotonin (5-hydroxytryptamine, 5-HT) receptor antagonists developed for mammals are ineffective in Aplysia due to the evolutionary divergence of neurotransmitter receptors and because the higher ionic strength of physiological saline for marine invertebrates reduces antagonist affinity. It has therefore been difficult to identify antagonists that specifically block individual signaling cascades initiated by 5-HT. We studied two broad-spectrum 5-HT receptor antagonists that have been characterized biochemically in Aplysia CNS: methiothepin and spiperone. Methiothepin is highly effective in inhibiting adenylyl cyclase (AC)-coupled 5-HT receptors in Aplysia. Spiperone, which blocks phospholipase C (PLC)-coupled 5-HT receptors in mammals, does not block AC-coupled 5-HT receptors in Aplysia. In electrophysiological studies, we explored whether methiothepin and spiperone can be used in parallel to distinguish between the AC-cAMP and PLC-protein kinase C (PKC) modulatory cascades that are initiated by 5-HT. 5-HT-induced broadening of the sensory neuron action potential in the presence of tetraethylammonium/nifedipine, which is mediated by modulation of the S-K + currents, was used an assay for the AC-cAMP cascade. Spike broadening initiated by 5 μM 5-HT was unaffected by 100 μM spiperone, whereas it was effectively blocked by 100 μM methiothepin. Facilitation of highly depressed sensory neuron-to-motor neuron synapses by 5-HT was used as an assay for the PLC-PKC cascade. Spiperone completely blocked facilitation of highly depressed synapses by 5 μM 5-HT. In contrast, methiothepin produced a modest, nonsignificant, reduction in the facilitation of depressed synapses. Interestingly, these experiments revealed that the PLC-PKC cascade undergoes desensitization during exposure to 5-HT." @default.
• W2014804312 created "2016-06-24" @default.
• W2014804312 creator A5003097864 @default.
• W2014804312 creator A5015491576 @default.
• W2014804312 creator A5033877762 @default.
• W2014804312 creator A5036251144 @default.
• W2014804312 creator A5036616517 @default.
• W2014804312 date "2006-04-01" @default.
• W2014804312 modified "2023-09-24" @default.
• W2014804312 title "Serotonin Receptor Antagonists Discriminate Between PKA- and PKC-Mediated Plasticity in<i>Aplysia</i>Sensory Neurons" @default.
• W2014804312 cites W1438374727 @default.
• W2014804312 cites W1492581478 @default.
• W2014804312 cites W1493453283 @default.
• W2014804312 cites W1501752630 @default.
• W2014804312 cites W1593340911 @default.
• W2014804312 cites W1600300223 @default.
• W2014804312 cites W1658066930 @default.
• W2014804312 cites W1842747747 @default.
• W2014804312 cites W1881742754 @default.
• W2014804312 cites W1941692718 @default.
• W2014804312 cites W1963851142 @default.
• W2014804312 cites W1965815102 @default.
• W2014804312 cites W1966286636 @default.
• W2014804312 cites W1982288973 @default.
• W2014804312 cites W1985340505 @default.
• W2014804312 cites W1998596192 @default.
• W2014804312 cites W2006336910 @default.
• W2014804312 cites W2008904681 @default.
• W2014804312 cites W2009823120 @default.
• W2014804312 cites W2010362159 @default.
• W2014804312 cites W2012604591 @default.
• W2014804312 cites W2013435143 @default.
• W2014804312 cites W2030180059 @default.
• W2014804312 cites W2049905665 @default.
• W2014804312 cites W2052487980 @default.
• W2014804312 cites W2054343388 @default.
• W2014804312 cites W2055817678 @default.
• W2014804312 cites W2056833797 @default.
• W2014804312 cites W2066592391 @default.
• W2014804312 cites W2067171615 @default.
• W2014804312 cites W2072529458 @default.
• W2014804312 cites W2073908596 @default.
• W2014804312 cites W2080383340 @default.
• W2014804312 cites W2081863440 @default.
• W2014804312 cites W2086608732 @default.
• W2014804312 cites W2111735128 @default.
• W2014804312 cites W2113594310 @default.
• W2014804312 cites W2113627100 @default.
• W2014804312 cites W2119546274 @default.
• W2014804312 cites W2138595433 @default.
• W2014804312 cites W2155981601 @default.
• W2014804312 cites W2157507214 @default.
• W2014804312 cites W2158294982 @default.
• W2014804312 cites W2166486911 @default.
• W2014804312 cites W2181681948 @default.
• W2014804312 cites W2184297541 @default.
• W2014804312 cites W2187065207 @default.
• W2014804312 cites W2340050943 @default.
• W2014804312 cites W2394763804 @default.
• W2014804312 cites W2415744812 @default.
• W2014804312 cites W2438826700 @default.
• W2014804312 cites W2439053919 @default.
• W2014804312 cites W2460389497 @default.
• W2014804312 cites W2466711611 @default.
• W2014804312 cites W4297802844 @default.
• W2014804312 cites W92854236 @default.
• W2014804312 doi "https://doi.org/10.1152/jn.00642.2005" @default.
• W2014804312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16236785" @default.
• W2014804312 hasPublicationYear "2006" @default.
• W2014804312 type Work @default.
• W2014804312 sameAs 2014804312 @default.
• W2014804312 citedByCount "25" @default.
• W2014804312 countsByYear W20148043122012 @default.
• W2014804312 countsByYear W20148043122014 @default.
• W2014804312 countsByYear W20148043122015 @default.
• W2014804312 countsByYear W20148043122016 @default.
• W2014804312 countsByYear W20148043122017 @default.
• W2014804312 countsByYear W20148043122018 @default.
• W2014804312 crossrefType "journal-article" @default.
• W2014804312 hasAuthorship W2014804312A5003097864 @default.
• W2014804312 hasAuthorship W2014804312A5015491576 @default.
• W2014804312 hasAuthorship W2014804312A5033877762 @default.
• W2014804312 hasAuthorship W2014804312A5036251144 @default.
• W2014804312 hasAuthorship W2014804312A5036616517 @default.
• W2014804312 hasConcept C169760540 @default.
• W2014804312 hasConcept C170493617 @default.
• W2014804312 hasConcept C185592680 @default.
• W2014804312 hasConcept C2775864247 @default.
• W2014804312 hasConcept C2775908076 @default.
• W2014804312 hasConcept C2776219046 @default.
• W2014804312 hasConcept C2777450907 @default.
• W2014804312 hasConcept C2778178740 @default.
• W2014804312 hasConcept C2781073084 @default.
• W2014804312 hasConcept C529278444 @default.
• W2014804312 hasConcept C53910766 @default.
• W2014804312 hasConcept C55493867 @default.
• W2014804312 hasConcept C86803240 @default.
• W2014804312 hasConcept C94487597 @default.

• next