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- W2014804465 abstract "Series of β-aryl-n-butyric (I), arylacetic (II), α-methyl-β-arylpropionic (III) and cinnamic (IV) acids were subjected to reversed-phase thin-layer chromatography on silica gel impregnated with silicone oil. In the series of acids I, II, and IV, characterized by a broad range of lipophilicity of the aromatic substituents, a non-linear course of the relationship between RM values and π parameters was found. The influence was studied of these non-linear relationships on the usability of RM values for the characterization of lipophilicity in quantitative structure-activity relationships. A change from a linear form of activity-π dependence to a parabolic form of activity-RM dependence was found solely in instances in which the statistical significance of the linear dependence was characterized by a high correlation coefficient, approaching 0.99. In such exceptional instances, requiring the highly accurate determination of the biological activity concerned, a fallacious quadratic activity-lipophilicity relationship may thus appear. In most of the regression equations studied, however, the use of RM values instead of π parameters did not influence the activity-lipophilicity relationships. With the aid of values obtained from partition chromatography, the lipophilicity of some disubstituted derivatives of acids I–IV was characterized, in which the addiditivy of the π parameters could be expected to fail as a result of the action of the ortho-effect of their substituents. For this purpose either the RM values were used directly, or π parameters calculated from the relationship between π and RM values were used." @default.
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- W2014804465 title "RM values from reversed-phase thin-layer chromatography as parameters of lipophilicity in quantitative structure-activity relationships in four series of arylaliphatic acids" @default.
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- W2014804465 doi "https://doi.org/10.1016/s0021-9673(00)81467-3" @default.
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