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- W2014804677 abstract "Abstract In young growing sheep ( ca 6 months of age), adrenaline (0.25 nmol·min −1 ·kg −1 intravenously for one hr, then 2.5 nmol·min −1 ·kg −1 for a second hr) decreased plasma K + concentration by 0.89 ± 0.109 mmol/l ( n = 4). In chronically cannulated late-gestation foetuses, however, adrenaline ( ca 2.5 then 5.0 nmol·min −1 ·kg −1 each for one hr) decreased plasma K + by only 0.26 ± 0.056 mmol/l ( n = 12), despite metabolic and cardiovascular changes of comparable magnitude to those in postnatal sheep. In vewborn lambs ( ca 1.25, then 6.0 nmol·min −1 ·kg −1 each for an hr) failed to decrease plasma K + significantly. In contrast, at 6 days of age, the decrease in plasma K + (0.71 ± 0.095 mmol/l, n = 5) during adrenaline infusion was similar to that in older sheep. The changes in plasma K + observed during adrenaline infusion into foetuses and growing sheep were totally abolished and those in lactate greatly attenuated after prolonged (6–8 days) infusion of a β 2 -selective adrenergic-receptor agonist, ritodrine. Because insulin decreases plasma K + in the foetus, these results imply a difference in developmental programming of the hypokalaemic action of catecholamines and insulin." @default.
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- W2014804677 title "Adrenaline and regulation of the plasma potassium concentration in foetal and newborn lambs" @default.
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- W2014804677 doi "https://doi.org/10.1016/0300-9629(95)02033-0" @default.
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