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• W2014804738 abstract "Due to its exquisite sensitivity to multiple sclerosis (MS) abnormalities, magnetic resonance imaging (MRI) has become an established tool to diagnose the disease and to monitor its evolution. MRI has been formally included in the diagnostic work up of patients at presentation with clinically isolated syndromes suggestive of MS, and ad hoc criteria have been proposed and are updated on a regular basis. On the contrary, in patients with established MS, the ability of MR measures in explaining patient clinical status and progression of disability is still suboptimal. This has prompted the extensive application of modern MR-based technologies to estimate overall MS burden in patients at different stages of the disease. The use of these techniques has allowed to grade in vivo the heterogeneity of MS pathology not only in focal lesions, but also in the normal-appearing white matter and gray matter. More recently, additional aspects of MS pathology, including macrophage infiltration and abnormal iron deposition have become quantifiable. Functional MRI (either task related or resting state) has provided important insights into cortical reorganization and how this might have an adaptive role in limiting the clinical consequences of structural damage. Furthermore, progress has been made assessing the spinal cord and the optic nerve. High-field-strength MRI scanners (7.0 T or more) are likely to advance further the understanding of damaging and reparative mechanisms of MS. All of this is progressively improving our understanding of the factors associated to MS progression. Due to its exquisite sensitivity to multiple sclerosis (MS) abnormalities, magnetic resonance imaging (MRI) has become an established tool to diagnose the disease and to monitor its evolution. MRI has been formally included in the diagnostic work up of patients at presentation with clinically isolated syndromes suggestive of MS, and ad hoc criteria have been proposed and are updated on a regular basis. On the contrary, in patients with established MS, the ability of MR measures in explaining patient clinical status and progression of disability is still suboptimal. This has prompted the extensive application of modern MR-based technologies to estimate overall MS burden in patients at different stages of the disease. The use of these techniques has allowed to grade in vivo the heterogeneity of MS pathology not only in focal lesions, but also in the normal-appearing white matter and gray matter. More recently, additional aspects of MS pathology, including macrophage infiltration and abnormal iron deposition have become quantifiable. Functional MRI (either task related or resting state) has provided important insights into cortical reorganization and how this might have an adaptive role in limiting the clinical consequences of structural damage. Furthermore, progress has been made assessing the spinal cord and the optic nerve. High-field-strength MRI scanners (7.0 T or more) are likely to advance further the understanding of damaging and reparative mechanisms of MS. All of this is progressively improving our understanding of the factors associated to MS progression." @default.
• W2014804738 created "2016-06-24" @default.
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• W2014804738 date "2014-11-01" @default.
• W2014804738 modified "2023-09-30" @default.
• W2014804738 title "Recent advances in MS neuroimaging" @default.
• W2014804738 doi "https://doi.org/10.1016/j.msard.2014.09.013" @default.
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