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• W2014805008 abstract "Triplex-forming peptide nucleic acids (PNAs) can be used to coordinate the recombination of short 50–60 bp “donor DNA” fragments into genomic DNA, resulting in site-specific correction of genetic mutations or the introduction of advantageous genetic modifications. Site-specific gene editing in hematopoietic stem and progenitor cells (HSPCs) could result in the treatment or cure of inherited disorders of the blood such as β-thalassemia or sickle cell anemia. Gene editing in HSPCs and differentiated T cells could also help combat HIV infection by modifying the HIV co-receptor CCR5, which is necessary for R5-tropic HIV entry. However, translation of genome modification technologies to clinical practice is limited by challenges in intracellular delivery, especially in difficult-to-transfect hematolymphoid cells. Here, we review the use of engineered biodegradable polymer nanoparticles for site-specific genome editing in human hematopoietic cells, which represent a promising approach for ex vivo and in vivo gene therapy." @default.
• W2014805008 created "2016-06-24" @default.
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• W2014805008 date "2011-10-01" @default.
• W2014805008 modified "2023-10-16" @default.
• W2014805008 title "Polymer delivery systems for site-specific genome editing" @default.
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• W2014805008 doi "https://doi.org/10.1016/j.jconrel.2011.05.011" @default.
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