FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014806005> ?p ?o ?g. }

• W2014806005 endingPage "1228" @default.
• W2014806005 startingPage "1220" @default.
• W2014806005 abstract "Maintenance of hepatic microcirculatory flow after ischemia of the liver is essential to prevent hepatic dysfunction. Thus, we determined the differential role of carbon monoxide (CO) and nitric oxide (NO) in the intrinsic control of sinusoidal perfusion, mitochondrial redox state, and bile production in the isolated perfused rat liver after hemorrhagic shock. Administration of tin protoporphyrin-IX (50 microM), a specific inhibitor of the CO generating enzyme heme oxygenase, caused a decrease in sinusoidal flow that was more pronounced after shock compared with sham shock, as determined by in situ epifluorescence microscopy. This was associated with a shift in hepatocellular redox potential to a more reduced state (increased fluorescence intensity of reduced pyridine nucleotides in hepatocytes, decreased acetoacetate/beta-hydroxybutyrate ratio in the perfusate) and a profound reduction in bile flow. In sharp contrast, the preferential inhibitor of the inducible isoform of NO synthase S-methylisothiourea sulfate (100 microM) did not affect sinusoidal flow, hepatic redox state, or function. This indicates that 1.) endogenously generated CO preserves sinusoidal perfusion after hemorrhagic shock, 2.) protection of the hepatic microcirculation by CO may serve to limit shock-induced liver dysfunction, and 3.) in contrast to CO, inducible NO synthase-derived NO is of only minor importance for the intrinsic control of hepatic perfusion and function under these conditions." @default.
• W2014806005 created "2016-06-24" @default.
• W2014806005 creator A5006751862 @default.
• W2014806005 creator A5044567209 @default.
• W2014806005 creator A5068261184 @default.
• W2014806005 creator A5069945667 @default.
• W2014806005 creator A5070257987 @default.
• W2014806005 creator A5085202174 @default.
• W2014806005 date "1998-09-15" @default.
• W2014806005 modified "2023-10-16" @default.
• W2014806005 title "Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats." @default.
• W2014806005 cites W1553693482 @default.
• W2014806005 cites W1561188729 @default.
• W2014806005 cites W1587935192 @default.
• W2014806005 cites W1598307552 @default.
• W2014806005 cites W1964111488 @default.
• W2014806005 cites W1964217931 @default.
• W2014806005 cites W1970464034 @default.
• W2014806005 cites W1983187255 @default.
• W2014806005 cites W1986675171 @default.
• W2014806005 cites W1991236355 @default.
• W2014806005 cites W2004491334 @default.
• W2014806005 cites W2007007507 @default.
• W2014806005 cites W2007737411 @default.
• W2014806005 cites W2010844371 @default.
• W2014806005 cites W2014916185 @default.
• W2014806005 cites W2016687652 @default.
• W2014806005 cites W2024401413 @default.
• W2014806005 cites W2026008412 @default.
• W2014806005 cites W2035674056 @default.
• W2014806005 cites W2039751259 @default.
• W2014806005 cites W2049690830 @default.
• W2014806005 cites W2051478582 @default.
• W2014806005 cites W2055899878 @default.
• W2014806005 cites W2060787616 @default.
• W2014806005 cites W2067728238 @default.
• W2014806005 cites W2072227605 @default.
• W2014806005 cites W2081643556 @default.
• W2014806005 cites W2085029083 @default.
• W2014806005 cites W2087516645 @default.
• W2014806005 cites W2087823687 @default.
• W2014806005 cites W2089819986 @default.
• W2014806005 cites W2111651135 @default.
• W2014806005 cites W2124433916 @default.
• W2014806005 cites W2127241668 @default.
• W2014806005 cites W2148156463 @default.
• W2014806005 cites W2177092899 @default.
• W2014806005 cites W2182588105 @default.
• W2014806005 cites W2189106682 @default.
• W2014806005 cites W2224209645 @default.
• W2014806005 cites W2277649884 @default.
• W2014806005 cites W2313326603 @default.
• W2014806005 cites W2316234491 @default.
• W2014806005 cites W2318065544 @default.
• W2014806005 cites W2343171406 @default.
• W2014806005 cites W2403342130 @default.
• W2014806005 cites W2405695130 @default.
• W2014806005 cites W2413235337 @default.
• W2014806005 cites W2415088294 @default.
• W2014806005 cites W2432140718 @default.
• W2014806005 cites W2436648429 @default.
• W2014806005 cites W2460472768 @default.
• W2014806005 cites W2463268648 @default.
• W2014806005 doi "https://doi.org/10.1172/jci3428" @default.
• W2014806005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/509105" @default.
• W2014806005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9739056" @default.
• W2014806005 hasPublicationYear "1998" @default.
• W2014806005 type Work @default.
• W2014806005 sameAs 2014806005 @default.
• W2014806005 citedByCount "154" @default.
• W2014806005 countsByYear W20148060052012 @default.
• W2014806005 countsByYear W20148060052013 @default.
• W2014806005 countsByYear W20148060052014 @default.
• W2014806005 countsByYear W20148060052015 @default.
• W2014806005 countsByYear W20148060052016 @default.
• W2014806005 countsByYear W20148060052017 @default.
• W2014806005 countsByYear W20148060052018 @default.
• W2014806005 countsByYear W20148060052019 @default.
• W2014806005 countsByYear W20148060052020 @default.
• W2014806005 countsByYear W20148060052021 @default.
• W2014806005 countsByYear W20148060052022 @default.
• W2014806005 countsByYear W20148060052023 @default.
• W2014806005 crossrefType "journal-article" @default.
• W2014806005 hasAuthorship W2014806005A5006751862 @default.
• W2014806005 hasAuthorship W2014806005A5044567209 @default.
• W2014806005 hasAuthorship W2014806005A5068261184 @default.
• W2014806005 hasAuthorship W2014806005A5069945667 @default.
• W2014806005 hasAuthorship W2014806005A5070257987 @default.
• W2014806005 hasAuthorship W2014806005A5085202174 @default.
• W2014806005 hasBestOaLocation W20148060051 @default.
• W2014806005 hasConcept C126322002 @default.
• W2014806005 hasConcept C12722491 @default.
• W2014806005 hasConcept C134018914 @default.
• W2014806005 hasConcept C146957229 @default.
• W2014806005 hasConcept C181199279 @default.
• W2014806005 hasConcept C185592680 @default.
• W2014806005 hasConcept C2776217839 @default.
• W2014806005 hasConcept C2777622882 @default.

• next