FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014814331> ?p ?o ?g. }

• W2014814331 endingPage "98" @default.
• W2014814331 startingPage "89" @default.
• W2014814331 abstract "The regulation of trophoblast apoptosis is essential for normal placentation, and increased placental trophoblast cell apoptosis is the cause of pathologies such as intrauterine growth retardation (IUGR) and pre-eclampsia. X-linked inhibitor of apoptosis (XIAP) is expressed in trophoblasts, but little is known about the role of XIAP in placental development. In the present study, the function of XIAP in the placenta and in HTR-8/SVneo trophoblasts under hypoxic conditions was examined. In addition, the correlation between XIAP and immortalization-upregulated protein-2 (IMUP-2) was demonstrated in HTR-8/SVneo trophoblasts under hypoxia, based on a previous study showing that increased IMUP-2 induces trophoblast apoptosis and pre-eclampsia. XIAP was downregulated in pre-eclamptic placentas (P < 0.05). In HTR-8/SVneo trophoblasts, XIAP expression was decreased and the expression of apoptosis-related genes was increased in response to hypoxia. Ectopic expression of hypoxia inducible factor (HIF)-1α in HRT-8 SV/neo cells induced the nuclear translocation of XIAP and alterations of XIAP protein stability. Furthermore, hypoxia induced nuclear translocated XIAP co-localized with upregulated IMUP-2 in trophoblast nuclei, and the interaction between XIAP and IMUP-2 induced apoptosis in HRT-8 SV/neo cells. The present results suggest that hypoxia-induced down-regulation of XIAP mediates apoptosis in trophoblasts through interaction with increased IMUP-2, and that this mechanism underlies the pathogenesis of pre-eclampsia. J. Cell. Biochem. 114: 89–98, 2012. © 2012 Wiley Periodicals, Inc." @default.
• W2014814331 created "2016-06-24" @default.
• W2014814331 creator A5021873236 @default.
• W2014814331 creator A5027533100 @default.
• W2014814331 creator A5028837275 @default.
• W2014814331 creator A5048668336 @default.
• W2014814331 creator A5063692305 @default.
• W2014814331 creator A5066903821 @default.
• W2014814331 creator A5068162617 @default.
• W2014814331 creator A5091660120 @default.
• W2014814331 date "2012-11-14" @default.
• W2014814331 modified "2023-09-22" @default.
• W2014814331 title "Hypoxia-induced downregulation of XIAP in trophoblasts mediates apoptosis via interaction with IMUP-2: Implications for placental development during pre-eclampsia" @default.
• W2014814331 cites W1551826730 @default.
• W2014814331 cites W1829810608 @default.
• W2014814331 cites W1970142478 @default.
• W2014814331 cites W1979071912 @default.
• W2014814331 cites W2002825609 @default.
• W2014814331 cites W2025499382 @default.
• W2014814331 cites W2031949901 @default.
• W2014814331 cites W2032943068 @default.
• W2014814331 cites W2047868879 @default.
• W2014814331 cites W2050452052 @default.
• W2014814331 cites W2066074894 @default.
• W2014814331 cites W2087746800 @default.
• W2014814331 cites W2093730092 @default.
• W2014814331 cites W2094985040 @default.
• W2014814331 cites W2095576458 @default.
• W2014814331 cites W2096800463 @default.
• W2014814331 cites W2113419678 @default.
• W2014814331 cites W2123123035 @default.
• W2014814331 cites W2144010503 @default.
• W2014814331 cites W2151389745 @default.
• W2014814331 cites W2164953175 @default.
• W2014814331 doi "https://doi.org/10.1002/jcb.24304" @default.
• W2014814331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22886722" @default.
• W2014814331 hasPublicationYear "2012" @default.
• W2014814331 type Work @default.
• W2014814331 sameAs 2014814331 @default.
• W2014814331 citedByCount "16" @default.
• W2014814331 countsByYear W20148143312013 @default.
• W2014814331 countsByYear W20148143312014 @default.
• W2014814331 countsByYear W20148143312015 @default.
• W2014814331 countsByYear W20148143312016 @default.
• W2014814331 countsByYear W20148143312017 @default.
• W2014814331 countsByYear W20148143312019 @default.
• W2014814331 countsByYear W20148143312020 @default.
• W2014814331 countsByYear W20148143312022 @default.
• W2014814331 countsByYear W20148143312023 @default.
• W2014814331 crossrefType "journal-article" @default.
• W2014814331 hasAuthorship W2014814331A5021873236 @default.
• W2014814331 hasAuthorship W2014814331A5027533100 @default.
• W2014814331 hasAuthorship W2014814331A5028837275 @default.
• W2014814331 hasAuthorship W2014814331A5048668336 @default.
• W2014814331 hasAuthorship W2014814331A5063692305 @default.
• W2014814331 hasAuthorship W2014814331A5066903821 @default.
• W2014814331 hasAuthorship W2014814331A5068162617 @default.
• W2014814331 hasAuthorship W2014814331A5091660120 @default.
• W2014814331 hasConcept C104317684 @default.
• W2014814331 hasConcept C127561419 @default.
• W2014814331 hasConcept C172680121 @default.
• W2014814331 hasConcept C178790620 @default.
• W2014814331 hasConcept C185592680 @default.
• W2014814331 hasConcept C190283241 @default.
• W2014814331 hasConcept C2776953305 @default.
• W2014814331 hasConcept C2777408456 @default.
• W2014814331 hasConcept C2777495146 @default.
• W2014814331 hasConcept C2779234561 @default.
• W2014814331 hasConcept C31573885 @default.
• W2014814331 hasConcept C33195913 @default.
• W2014814331 hasConcept C45167389 @default.
• W2014814331 hasConcept C502942594 @default.
• W2014814331 hasConcept C540031477 @default.
• W2014814331 hasConcept C54355233 @default.
• W2014814331 hasConcept C55493867 @default.
• W2014814331 hasConcept C7836513 @default.
• W2014814331 hasConcept C86803240 @default.
• W2014814331 hasConcept C95444343 @default.
• W2014814331 hasConcept C98424977 @default.
• W2014814331 hasConceptScore W2014814331C104317684 @default.
• W2014814331 hasConceptScore W2014814331C127561419 @default.
• W2014814331 hasConceptScore W2014814331C172680121 @default.
• W2014814331 hasConceptScore W2014814331C178790620 @default.
• W2014814331 hasConceptScore W2014814331C185592680 @default.
• W2014814331 hasConceptScore W2014814331C190283241 @default.
• W2014814331 hasConceptScore W2014814331C2776953305 @default.
• W2014814331 hasConceptScore W2014814331C2777408456 @default.
• W2014814331 hasConceptScore W2014814331C2777495146 @default.
• W2014814331 hasConceptScore W2014814331C2779234561 @default.
• W2014814331 hasConceptScore W2014814331C31573885 @default.
• W2014814331 hasConceptScore W2014814331C33195913 @default.
• W2014814331 hasConceptScore W2014814331C45167389 @default.
• W2014814331 hasConceptScore W2014814331C502942594 @default.
• W2014814331 hasConceptScore W2014814331C540031477 @default.
• W2014814331 hasConceptScore W2014814331C54355233 @default.
• W2014814331 hasConceptScore W2014814331C55493867 @default.
• W2014814331 hasConceptScore W2014814331C7836513 @default.
• W2014814331 hasConceptScore W2014814331C86803240 @default.

• next