FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014818066> ?p ?o ?g. }

• W2014818066 endingPage "961" @default.
• W2014818066 startingPage "953" @default.
• W2014818066 abstract "Proliferative responses of mononuclear cells from patients seropositive for human immunodeficiency virus to B-cell mitogens are severely depressed compared with those of controls. The role of several immunoregulatory phenomena was analyzed. Experimental results show that addition of exogenous lymphokines to cultures increases responses to anti-μ and SAC. Addition of indomethacin to cultures greatly increases the SAC response and causes a smaller increase in the pokeweed mitogen (PWM) response. When both exogenous lymphokines and indomethacin are present in cultures, responses of patients' cells to all three mitogens are positively correlated with the percentage of CD4+ T cells and negatively correlated with the percentage of CD8+ T cells. Responses to anti-μ and SAC are also positively correlated with the percentage of B cells in these cultures. On the basis of these correlations between B-cell responses and lymphocyte subset frequency, patients' B-cell responses can be mathematically corrected to estimate the responsiveness of the B cells in the presence of normal numbers of CD4+ and CD8+ cells. These corrected responses for all three mitogens are virtually identical to control responses. Furthermore, responses of enriched B-cell populations from HIV+ subjects and normal controls to SAC were not significantly different when assays were performed in the presence of indomethacin and exogenous lymphokines. These results suggest that B cells from HIV+ patients are inherently normal in their responsiveness to B-cell mitogens. The depressed function is imposed upon them as a result of the abnormal frequency of lymphocyte subsets in the blood, by increased prostaglandin production, and deficient lymphokine production." @default.
• W2014818066 created "2016-06-24" @default.
• W2014818066 creator A5041332295 @default.
• W2014818066 creator A5069686110 @default.
• W2014818066 date "1991-11-01" @default.
• W2014818066 modified "2023-09-26" @default.
• W2014818066 title "Proliferative Response of Mononuclear Cells from HIV-Infected Patients to B-Cell Mitogens: Effects Of Lymphocyte Subset Frequency, T-Cell Defects and Prostaglandins" @default.
• W2014818066 cites W1505871205 @default.
• W2014818066 cites W1515033630 @default.
• W2014818066 cites W1518009762 @default.
• W2014818066 cites W1588648491 @default.
• W2014818066 cites W1616501289 @default.
• W2014818066 cites W180906928 @default.
• W2014818066 cites W191218928 @default.
• W2014818066 cites W1969491032 @default.
• W2014818066 cites W1974865346 @default.
• W2014818066 cites W1975651602 @default.
• W2014818066 cites W1985143680 @default.
• W2014818066 cites W1985680056 @default.
• W2014818066 cites W1989511321 @default.
• W2014818066 cites W2022819455 @default.
• W2014818066 cites W2023769314 @default.
• W2014818066 cites W2027767297 @default.
• W2014818066 cites W2030692398 @default.
• W2014818066 cites W2031363581 @default.
• W2014818066 cites W2035674410 @default.
• W2014818066 cites W2036919895 @default.
• W2014818066 cites W2038887686 @default.
• W2014818066 cites W2060369372 @default.
• W2014818066 cites W2061308559 @default.
• W2014818066 cites W2065413764 @default.
• W2014818066 cites W2066121768 @default.
• W2014818066 cites W2074376964 @default.
• W2014818066 cites W2074672970 @default.
• W2014818066 cites W2095729328 @default.
• W2014818066 cites W2118588327 @default.
• W2014818066 cites W2122302780 @default.
• W2014818066 cites W2130694207 @default.
• W2014818066 cites W2145893310 @default.
• W2014818066 cites W2149251500 @default.
• W2014818066 cites W2159669315 @default.
• W2014818066 cites W2319153630 @default.
• W2014818066 cites W2321907477 @default.
• W2014818066 cites W2412483042 @default.
• W2014818066 cites W51893898 @default.
• W2014818066 doi "https://doi.org/10.1089/aid.1991.7.953" @default.
• W2014818066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1760232" @default.
• W2014818066 hasPublicationYear "1991" @default.
• W2014818066 type Work @default.
• W2014818066 sameAs 2014818066 @default.
• W2014818066 citedByCount "2" @default.
• W2014818066 crossrefType "journal-article" @default.
• W2014818066 hasAuthorship W2014818066A5041332295 @default.
• W2014818066 hasAuthorship W2014818066A5069686110 @default.
• W2014818066 hasConcept C126322002 @default.
• W2014818066 hasConcept C134018914 @default.
• W2014818066 hasConcept C137061746 @default.
• W2014818066 hasConcept C159654299 @default.
• W2014818066 hasConcept C167672396 @default.
• W2014818066 hasConcept C202751555 @default.
• W2014818066 hasConcept C203014093 @default.
• W2014818066 hasConcept C2776090121 @default.
• W2014818066 hasConcept C2777761686 @default.
• W2014818066 hasConcept C2778453870 @default.
• W2014818066 hasConcept C2781005381 @default.
• W2014818066 hasConcept C2992881475 @default.
• W2014818066 hasConcept C49382859 @default.
• W2014818066 hasConcept C55493867 @default.
• W2014818066 hasConcept C71924100 @default.
• W2014818066 hasConcept C86803240 @default.
• W2014818066 hasConcept C8891405 @default.
• W2014818066 hasConceptScore W2014818066C126322002 @default.
• W2014818066 hasConceptScore W2014818066C134018914 @default.
• W2014818066 hasConceptScore W2014818066C137061746 @default.
• W2014818066 hasConceptScore W2014818066C159654299 @default.
• W2014818066 hasConceptScore W2014818066C167672396 @default.
• W2014818066 hasConceptScore W2014818066C202751555 @default.
• W2014818066 hasConceptScore W2014818066C203014093 @default.
• W2014818066 hasConceptScore W2014818066C2776090121 @default.
• W2014818066 hasConceptScore W2014818066C2777761686 @default.
• W2014818066 hasConceptScore W2014818066C2778453870 @default.
• W2014818066 hasConceptScore W2014818066C2781005381 @default.
• W2014818066 hasConceptScore W2014818066C2992881475 @default.
• W2014818066 hasConceptScore W2014818066C49382859 @default.
• W2014818066 hasConceptScore W2014818066C55493867 @default.
• W2014818066 hasConceptScore W2014818066C71924100 @default.
• W2014818066 hasConceptScore W2014818066C86803240 @default.
• W2014818066 hasConceptScore W2014818066C8891405 @default.
• W2014818066 hasIssue "11" @default.
• W2014818066 hasLocation W20148180661 @default.
• W2014818066 hasLocation W20148180662 @default.
• W2014818066 hasOpenAccess W2014818066 @default.
• W2014818066 hasPrimaryLocation W20148180661 @default.
• W2014818066 hasRelatedWork W1506984959 @default.
• W2014818066 hasRelatedWork W2014818066 @default.
• W2014818066 hasRelatedWork W2056385328 @default.
• W2014818066 hasRelatedWork W208986397 @default.
• W2014818066 hasRelatedWork W2090531156 @default.

• next