FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014824103> ?p ?o ?g. }

• W2014824103 endingPage "9" @default.
• W2014824103 startingPage "1" @default.
• W2014824103 abstract "Asymmetric dimethylarginine (ADMA) induces vascular smooth muscle cells (VSMCs) migration. VSMC phenotype change is a prerequisite of migration. RhoA and Rho-kinase (ROCK) mediate migration of VSMCs. We hypothesize that ADMA induces VSMC migration via the activation of Rho/ROCK signal pathway and due to VSMCs phenotype change. ADMA activates Rho/ROCK signal pathway that interpreted by the elevation of RhoA activity and phosphorylation level of a ROCK substrate. Pretreatment with ROCK inhibitor, Y27632 completely reverses the induction of ADMA on ROCK and in turn inhibits ADMA-induced VSMCs migration. When the Rho/ROCK signal pathway has been blocked by pretreatment with Y27632, the induction of ERK signal pathway by ADMA is completely abrogated. Elimination of ADMA via overexpression of dimethylarginine dimethylaminohydrolase 2 (DDAH2) and L-arginine both blocks the effects of ADMA on the activation of Rho/ROCK and extra cellular signal-regulated kinase (ERK) in VSMCs. The expression of differentiated phenotype relative proteins was reduced and the actin cytoskeleton was disassembled by ADMA, which were blocked by Y27632, further interpreting that ADMA inducing VSMCs migration via Rho/ROCK signal pathway is due to its effect on the VSMCs phenotype change. Our present study may help to provide novel insights into the therapy and prevention of atherosclerosis." @default.
• W2014824103 created "2016-06-24" @default.
• W2014824103 creator A5024510057 @default.
• W2014824103 creator A5070463960 @default.
• W2014824103 creator A5070504334 @default.
• W2014824103 creator A5072662743 @default.
• W2014824103 creator A5078104569 @default.
• W2014824103 creator A5086664284 @default.
• W2014824103 date "2014-01-01" @default.
• W2014824103 modified "2023-09-26" @default.
• W2014824103 title "Rho/ROCK Signal Cascade Mediates Asymmetric Dimethylarginine-Induced Vascular Smooth Muscle Cells Migration and Phenotype Change" @default.
• W2014824103 cites W1491620417 @default.
• W2014824103 cites W1910650341 @default.
• W2014824103 cites W1963996264 @default.
• W2014824103 cites W1981944497 @default.
• W2014824103 cites W1985344101 @default.
• W2014824103 cites W2003289800 @default.
• W2014824103 cites W2008740882 @default.
• W2014824103 cites W2009299673 @default.
• W2014824103 cites W2028755914 @default.
• W2014824103 cites W2054258901 @default.
• W2014824103 cites W2072531665 @default.
• W2014824103 cites W2075778216 @default.
• W2014824103 cites W2078467232 @default.
• W2014824103 cites W2084525068 @default.
• W2014824103 cites W2092766833 @default.
• W2014824103 cites W2096334465 @default.
• W2014824103 cites W2105789054 @default.
• W2014824103 cites W2133246254 @default.
• W2014824103 cites W2133846289 @default.
• W2014824103 cites W2140217457 @default.
• W2014824103 cites W2162378772 @default.
• W2014824103 cites W2168048697 @default.
• W2014824103 cites W2170760765 @default.
• W2014824103 doi "https://doi.org/10.1155/2014/683707" @default.
• W2014824103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4119924" @default.
• W2014824103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25121106" @default.
• W2014824103 hasPublicationYear "2014" @default.
• W2014824103 type Work @default.
• W2014824103 sameAs 2014824103 @default.
• W2014824103 citedByCount "8" @default.
• W2014824103 countsByYear W20148241032017 @default.
• W2014824103 countsByYear W20148241032019 @default.
• W2014824103 countsByYear W20148241032020 @default.
• W2014824103 countsByYear W20148241032021 @default.
• W2014824103 countsByYear W20148241032022 @default.
• W2014824103 countsByYear W20148241032023 @default.
• W2014824103 crossrefType "journal-article" @default.
• W2014824103 hasAuthorship W2014824103A5024510057 @default.
• W2014824103 hasAuthorship W2014824103A5070463960 @default.
• W2014824103 hasAuthorship W2014824103A5070504334 @default.
• W2014824103 hasAuthorship W2014824103A5072662743 @default.
• W2014824103 hasAuthorship W2014824103A5078104569 @default.
• W2014824103 hasAuthorship W2014824103A5086664284 @default.
• W2014824103 hasBestOaLocation W20148241031 @default.
• W2014824103 hasConcept C104317684 @default.
• W2014824103 hasConcept C11960822 @default.
• W2014824103 hasConcept C126322002 @default.
• W2014824103 hasConcept C127716648 @default.
• W2014824103 hasConcept C134018914 @default.
• W2014824103 hasConcept C185592680 @default.
• W2014824103 hasConcept C201800478 @default.
• W2014824103 hasConcept C2777093181 @default.
• W2014824103 hasConcept C2777468819 @default.
• W2014824103 hasConcept C2778609687 @default.
• W2014824103 hasConcept C2779395532 @default.
• W2014824103 hasConcept C2779877776 @default.
• W2014824103 hasConcept C2992686903 @default.
• W2014824103 hasConcept C515207424 @default.
• W2014824103 hasConcept C55493867 @default.
• W2014824103 hasConcept C57074206 @default.
• W2014824103 hasConcept C62478195 @default.
• W2014824103 hasConcept C71924100 @default.
• W2014824103 hasConcept C86803240 @default.
• W2014824103 hasConcept C95444343 @default.
• W2014824103 hasConceptScore W2014824103C104317684 @default.
• W2014824103 hasConceptScore W2014824103C11960822 @default.
• W2014824103 hasConceptScore W2014824103C126322002 @default.
• W2014824103 hasConceptScore W2014824103C127716648 @default.
• W2014824103 hasConceptScore W2014824103C134018914 @default.
• W2014824103 hasConceptScore W2014824103C185592680 @default.
• W2014824103 hasConceptScore W2014824103C201800478 @default.
• W2014824103 hasConceptScore W2014824103C2777093181 @default.
• W2014824103 hasConceptScore W2014824103C2777468819 @default.
• W2014824103 hasConceptScore W2014824103C2778609687 @default.
• W2014824103 hasConceptScore W2014824103C2779395532 @default.
• W2014824103 hasConceptScore W2014824103C2779877776 @default.
• W2014824103 hasConceptScore W2014824103C2992686903 @default.
• W2014824103 hasConceptScore W2014824103C515207424 @default.
• W2014824103 hasConceptScore W2014824103C55493867 @default.
• W2014824103 hasConceptScore W2014824103C57074206 @default.
• W2014824103 hasConceptScore W2014824103C62478195 @default.
• W2014824103 hasConceptScore W2014824103C71924100 @default.
• W2014824103 hasConceptScore W2014824103C86803240 @default.
• W2014824103 hasConceptScore W2014824103C95444343 @default.
• W2014824103 hasFunder F4320321001 @default.
• W2014824103 hasLocation W20148241031 @default.
• W2014824103 hasLocation W20148241032 @default.

• next