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- W2014828596 abstract "Great progress has been made in understanding the HCV genome and its molecular virology. This understanding has culminated in the development of direct-acting antiviral (DAA) agents targeting HCV viral proteins. Telaprevir (TVR) and boceprevir (BOC) were the first DAAs introduced for treatment of genotype 1 HCV in 2011; when used in combination with pegylated interferon (pegIFN) and ribavirin (RBV), these protease inhibitors improved efficacy in patients with chronic HCV infection compared to the traditional dual therapy. However, this combination was associated with adverse events that often led to early termination of therapy. In late 2013, the FDA approved a second wave of DAAs, sofosbuvir (SOF) and simeprevir (SMV). The use of SOF with SMV opened the door for IFN-free combination regimens. This combination was highly efficacious and well tolerated in patients with HCV genotype 1. Sofosbuvir and ledipasvir (LDV) fixed-dose oral combination (FDC) therapy, and paritaprevir/ritonavir, ombitasvir and dasabuvir ± RBV were recently approved, elevating sustained virologic response (SVR) rates to over 95 %. We are anticipating the approval of additional IFN-free regimens with comparable efficacy and tolerability but with the addition of pangenotypic coverage, fewer drug-drug interactions, and a high barrier to resistance. This review will summarize current management for chronic HCV infection." @default.
- W2014828596 created "2016-06-24" @default.
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- W2014828596 date "2015-03-01" @default.
- W2014828596 modified "2023-10-09" @default.
- W2014828596 title "Enhancing Our Understanding of Current Therapies for Hepatitis C Virus (HCV)" @default.
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- W2014828596 cites W1602347566 @default.
- W2014828596 cites W162603234 @default.
- W2014828596 cites W1808615540 @default.
- W2014828596 cites W1958727566 @default.
- W2014828596 cites W1967657617 @default.
- W2014828596 cites W1970062940 @default.
- W2014828596 cites W1972821220 @default.
- W2014828596 cites W1973675889 @default.
- W2014828596 cites W1976745213 @default.
- W2014828596 cites W1980771473 @default.
- W2014828596 cites W1992668008 @default.
- W2014828596 cites W1996872932 @default.
- W2014828596 cites W2000851328 @default.
- W2014828596 cites W2002142691 @default.
- W2014828596 cites W2004560175 @default.
- W2014828596 cites W2006309458 @default.
- W2014828596 cites W2012873354 @default.
- W2014828596 cites W2018798881 @default.
- W2014828596 cites W2020323079 @default.
- W2014828596 cites W2021207134 @default.
- W2014828596 cites W2021668929 @default.
- W2014828596 cites W2022687771 @default.
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- W2014828596 cites W2042158802 @default.
- W2014828596 cites W2043193067 @default.
- W2014828596 cites W2045390938 @default.
- W2014828596 cites W2048778984 @default.
- W2014828596 cites W2049390811 @default.
- W2014828596 cites W2052533488 @default.
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- W2014828596 cites W2068253682 @default.
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- W2014828596 cites W2081897332 @default.
- W2014828596 cites W2092646281 @default.
- W2014828596 cites W2097888434 @default.
- W2014828596 cites W2103796460 @default.
- W2014828596 cites W2105947305 @default.
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- W2014828596 cites W2315634424 @default.
- W2014828596 cites W2322279641 @default.
- W2014828596 cites W2324690778 @default.
- W2014828596 cites W2362391013 @default.
- W2014828596 cites W2402657517 @default.
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- W2014828596 doi "https://doi.org/10.1007/s11904-014-0243-7" @default.
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