FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014860679> ?p ?o ?g. }

• W2014860679 endingPage "943" @default.
• W2014860679 startingPage "934" @default.
• W2014860679 abstract "We have previously shown that interleukin (IL-)10-induced proliferation of the murine mast cell line D36, was dependent upon the activation of PI 3-kinase and p70 S6 kinase. Conversely, we were able to show that this pathway was not involved in the signal transduction pathway mediating IL-10 inhibition of pro-inflammatory cytokine release from monocytes. We have extended these studies to investigate the induction of p75 tumour necrosis factor receptor (TNF-R) shedding, another anti-inflammatory property of IL-10. Using the inhibitors of PI 3-kinase (LY294002 and wortmannin) and an inhibitor of p70 S6 kinase activation (rapamycin), we were able to show that this anti-inflammatory effect of IL-10 was not mediated by the PI 3-kinase/p70 S6 kinase pathway, indicating that another signalling cascade(s) was involved. Further studies also investigated the role of tyrosine kinases in the response to IL-10. Two distinct tyrosine kinase inhibitors, herbimycin and genistein affected the expression of TNF-R in response to IL-10 but, surprisingly, with opposite effects. However, both compounds inhibited the activation of both PI 3-kinase and p70 S6 kinase, with a concomitant inhibition of IL-10-induced proliferation. We observed that whilst tyrosine kinase activity was involved in the regulation of TNF-R expression, IL-10-induced activation of JAK kinases was not sensitive to inhibition by the tyrosine kinase inhibitors. These data suggest that multiple unknown tyrosine kinases are mediating the IL-10-induced signal transduction pathways leading to the regulation of TNF-R expression and IL-10-induced proliferation." @default.
• W2014860679 created "2016-06-24" @default.
• W2014860679 creator A5018434601 @default.
• W2014860679 creator A5020029085 @default.
• W2014860679 creator A5047430026 @default.
• W2014860679 creator A5049830929 @default.
• W2014860679 creator A5077042688 @default.
• W2014860679 date "2000-07-01" @default.
• W2014860679 modified "2023-10-17" @default.
• W2014860679 title "INTERLEUKIN 10 MODULATION OF TUMOUR NECROSIS FACTOR RECEPTORS REQUIRES TYROSINE KINASES BUT NOT THE PI 3-KINASE/p70 S6 KINASE PATHWAY" @default.
• W2014860679 cites W127609430 @default.
• W2014860679 cites W1499527462 @default.
• W2014860679 cites W1504084694 @default.
• W2014860679 cites W1511368491 @default.
• W2014860679 cites W1517658874 @default.
• W2014860679 cites W1538802759 @default.
• W2014860679 cites W1554693647 @default.
• W2014860679 cites W1594483144 @default.
• W2014860679 cites W1595612667 @default.
• W2014860679 cites W1670792975 @default.
• W2014860679 cites W1817120227 @default.
• W2014860679 cites W1969161473 @default.
• W2014860679 cites W1972941866 @default.
• W2014860679 cites W1973155132 @default.
• W2014860679 cites W1979187651 @default.
• W2014860679 cites W1979922465 @default.
• W2014860679 cites W1981101169 @default.
• W2014860679 cites W1981533854 @default.
• W2014860679 cites W1984035854 @default.
• W2014860679 cites W1985174579 @default.
• W2014860679 cites W2002144356 @default.
• W2014860679 cites W2023845407 @default.
• W2014860679 cites W2035552180 @default.
• W2014860679 cites W2038977750 @default.
• W2014860679 cites W2042307667 @default.
• W2014860679 cites W2069035291 @default.
• W2014860679 cites W2072011504 @default.
• W2014860679 cites W2092117527 @default.
• W2014860679 cites W2094228209 @default.
• W2014860679 cites W2120409061 @default.
• W2014860679 cites W2127048642 @default.
• W2014860679 cites W2145218870 @default.
• W2014860679 cites W2146271551 @default.
• W2014860679 cites W2149805219 @default.
• W2014860679 cites W2158498820 @default.
• W2014860679 cites W2312357257 @default.
• W2014860679 cites W4231581694 @default.
• W2014860679 cites W89340416 @default.
• W2014860679 doi "https://doi.org/10.1006/cyto.1999.0673" @default.
• W2014860679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10880238" @default.
• W2014860679 hasPublicationYear "2000" @default.
• W2014860679 type Work @default.
• W2014860679 sameAs 2014860679 @default.
• W2014860679 citedByCount "8" @default.
• W2014860679 crossrefType "journal-article" @default.
• W2014860679 hasAuthorship W2014860679A5018434601 @default.
• W2014860679 hasAuthorship W2014860679A5020029085 @default.
• W2014860679 hasAuthorship W2014860679A5047430026 @default.
• W2014860679 hasAuthorship W2014860679A5049830929 @default.
• W2014860679 hasAuthorship W2014860679A5077042688 @default.
• W2014860679 hasConcept C101544691 @default.
• W2014860679 hasConcept C104202773 @default.
• W2014860679 hasConcept C112392421 @default.
• W2014860679 hasConcept C124160383 @default.
• W2014860679 hasConcept C137361374 @default.
• W2014860679 hasConcept C157333092 @default.
• W2014860679 hasConcept C159479382 @default.
• W2014860679 hasConcept C170493617 @default.
• W2014860679 hasConcept C180361614 @default.
• W2014860679 hasConcept C184235292 @default.
• W2014860679 hasConcept C185592680 @default.
• W2014860679 hasConcept C195794163 @default.
• W2014860679 hasConcept C2775960820 @default.
• W2014860679 hasConcept C42362537 @default.
• W2014860679 hasConcept C502942594 @default.
• W2014860679 hasConcept C55493867 @default.
• W2014860679 hasConcept C62478195 @default.
• W2014860679 hasConcept C82495950 @default.
• W2014860679 hasConcept C86554907 @default.
• W2014860679 hasConcept C86803240 @default.
• W2014860679 hasConcept C90934575 @default.
• W2014860679 hasConcept C95444343 @default.
• W2014860679 hasConcept C97029542 @default.
• W2014860679 hasConceptScore W2014860679C101544691 @default.
• W2014860679 hasConceptScore W2014860679C104202773 @default.
• W2014860679 hasConceptScore W2014860679C112392421 @default.
• W2014860679 hasConceptScore W2014860679C124160383 @default.
• W2014860679 hasConceptScore W2014860679C137361374 @default.
• W2014860679 hasConceptScore W2014860679C157333092 @default.
• W2014860679 hasConceptScore W2014860679C159479382 @default.
• W2014860679 hasConceptScore W2014860679C170493617 @default.
• W2014860679 hasConceptScore W2014860679C180361614 @default.
• W2014860679 hasConceptScore W2014860679C184235292 @default.
• W2014860679 hasConceptScore W2014860679C185592680 @default.
• W2014860679 hasConceptScore W2014860679C195794163 @default.
• W2014860679 hasConceptScore W2014860679C2775960820 @default.
• W2014860679 hasConceptScore W2014860679C42362537 @default.
• W2014860679 hasConceptScore W2014860679C502942594 @default.

• next