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- W2014861565 abstract "Twenty-five to 30 % of blood lymphocytes from a myeloma patient with an IgGl(k) protein with antibody activity to horse α2-macroglobulin (α2M) reacted with purified IgG from a rabbit antiserum to the idiotypic determinants of this protein. A small proportion of these idiotype-bearing lymphocytes were IgG-bearing B cells, but most of them were T cells. Several experiments demonstrated the actual synthesis of the idiotypic structures carried by the T lymphocytes. All idiotype-bearing lymphocytes bound horse α2M, and the structures that bore the idiotype and bound the antigen were shown to completely cocap. After biosynthetic labeling with 14C-labeled amino acids, immunoprecipitation and sodium dodecyl sulfate gel electrophoresis, the anti-idiotypic serum and the α2M antigen were found to react with the same molecules. Preliminary data on the size of these antigen-binding T lymphocyte-derived molecules are in accord with those of Binz and Wigzell (Scand. J. Immunol. 1976. 5: 559) in the rat. The finding in this patient with multiple myeloma of a homogeneous and possibly malignant population of T lymphocytes, synthesizing identical antigen receptors which share idiotypic (but not isotypic) determinants of the immunoglobulin molecule produced by the malignant B cell clone, therefore confirms in man the results of several recent studies in other mammalian species." @default.
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- W2014861565 date "1977-12-01" @default.
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- W2014861565 title "Idiotype-bearing and antigen-binding receptors produced by blood T lymphocytes in a case of human myeloma" @default.
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- W2014861565 doi "https://doi.org/10.1002/eji.1830071204" @default.
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