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- W2014862312 endingPage "175" @default.
- W2014862312 startingPage "159" @default.
- W2014862312 abstract "Stroke continues to be a major cause of death and disability. The currently available therapies have proven to be highly unsatisfactory (except thrombolysis) and attempts are being made to identify and characterize signalling proteins which could be exploited to design novel therapeutic modalities. The pathophysiology of stroke is a complex process. Delaying interventions from the first hours to days or even weeks following blood vessel occlusion may lead to worsening or impairment of recovery in later stages. The objective of this review is to critically evaluate the major mechanisms underlying stroke pathophysiology, especially the role of cell signalling in excitotoxicity, inflammation, apoptosis, neuroprotection and angiogenesis, and highlight potential novel targets for drug discovery." @default.
- W2014862312 created "2016-06-24" @default.
- W2014862312 creator A5017487492 @default.
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- W2014862312 creator A5066710703 @default.
- W2014862312 date "2006-01-01" @default.
- W2014862312 modified "2023-10-09" @default.
- W2014862312 title "Pathophysiology of Acute Ischaemic Stroke: An Analysis of Common Signalling Mechanisms and Identification of New Molecular Targets" @default.
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