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- W2014864514 abstract "Following a powder dehydration process, the surface-modified anhydrates (EA, PA and BA) of nitrofurantoin were obtained in a specially designed surface-modification apparatus at 60 °C via the adsorption of ethanol, n-propanol and n-butanol, respectively. The intact (IA) nitrofurantoin was used as control. The X-ray diffraction, FT-IR and DSC results suggested that the crystalline characteristics of anhydrate were not affected by surface-modification treatment, such as the adsorption of ethanol, n-propanol or n-butanol. Powder X-ray diffraction and differential scanning calorimetric (DSC) were used to determine the crystalline characteristics of the samples that had been stored at 93% relative humidity (RH) and at 40±1°C. The hydration of surface-modified samples followed a first-order process with an induction period. The hydration rate constants obtained by the X-ray diffraction method were in the order of PA≈BA<EA<IA. The associated induction periods were in the order of BA≥PA>EA>IA. On the other hand, the order of hydration rate constants measured by DSC method was PA≈BA<EA<IA with induction periods of BA≥PA>EA>IA. The values of kinetic parameters obtained by DSC method were different from those obtained by X-ray diffraction method. The results suggested that the surface-modified anhydrates were more stable in high humidity condition than intact, and the surface-modification by n-butanol or n-propanol adsorption was more effective than that by ethanol. The dissolution test for surface-modified samples was performed following the method as stipulated in the Japanese Pharmacopoeia XIII. Briefly, 20 mg of sample powder was introduced into 900 ml of distilled water at 37±0.5 °C with stirring by a paddle at 0 or 100 rpm. The dissolution kinetics was analyzed based on Hixon–Crowell equation. In the dynamic condition (100 rpm), the dissolution profile of surface-modified sample by n-butanol was superimposable to that of intact sample. In contrast, under the static dissolution condition the intact sample showed faster dissolution than the surface-modified initially. The result indicated that wetability of the sample decreased by surface-modification using n-butanol." @default.
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- W2014864514 date "2002-01-01" @default.
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- W2014864514 title "Effect of surface-modification on hydration kinetics of nitrofurantoin anhydrate" @default.
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- W2014864514 doi "https://doi.org/10.1016/s0927-7765(01)00210-7" @default.
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