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- W2014865322 abstract "Aims: To study the role of sinomenine (SIN) in prolonging high-risk corneal graft survival in rats. Methods: All recipients were randomly assigned to SIN, cyclosporine A (CsA), SIN plus CsA and control groups. IL-2, IL-10, Fas–Fas ligand and CD4 + CD25 + FoxP3 + T cells in peripheral blood were detected. In addition, rat corneal grafts’ survival times were recorded. Results: Survival time was 15.88 ± 5.87 days in the SIN group, 17.67 ± 5.43 days in the CsA group and 20.75 ± 4.77 days in the drug combination group, which were longer survival times than those in the control group (p < 0.05). Compared with the SIN and CsA groups, levels of CD4 + CD25 + FoxP3 + lymphocytes in the control group were decreased (p < 0.05) and were increased in the cotreated group (p < 0.05). IL-2 levels in the SIN-only and CsA-only groups were lower than those in the control group (p < 0.05) and higher than those in the cotreated group (p < 0.05); however, the results for IL-10 were different. The expressions of Fas and Fas ligand were least in the control group. Conclusion: SIN could prolong allograft survival and might have potential clinical usage." @default.
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- W2014865322 date "2012-06-01" @default.
- W2014865322 modified "2023-09-28" @default.
- W2014865322 title "Sinomenine can prolong high-risk corneal graft survival in a rat model" @default.
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- W2014865322 doi "https://doi.org/10.2217/imt.12.45" @default.
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