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- W2014874657 abstract "Transposable elements (TEs) are known to influence the regulation of neighboring genes through a variety of mechanisms. Additionally, it was recently discovered that TEs can regulate non-neighboring genes through the trans-acting nature of small interfering RNAs (siRNAs). When the epigenetic repression of TEs is lost, TEs become transcriptionally active, and the host cell acts to repress mutagenic transposition by degrading TE mRNAs into siRNAs. In this study, we have performed a genome-wide analysis in the model plant Arabidopsis thaliana and found that TE siRNA-based regulation of genic mRNAs is more pervasive than the two formerly characterized proof-of-principle examples. We identified 27 candidate genic mRNAs that do not contain a TE fragment but are regulated through partial complementarity by the accumulation of TE siRNAs and are therefore influenced by TE epigenetic activation. We have experimentally confirmed several gene targets and demonstrated that they respond to the accumulation of specific 21 nucleotide TE siRNAs that are incorporated into the Arabidopsis Argonaute1 protein. Additionally, we found that one TE siRNA specifically targets and inhibits the formation of a host protein that acts to repress TE activity, suggesting that TEs harbor and potentially evolutionarily select short sequences to act as suppressors of host TE repression." @default.
- W2014874657 created "2016-06-24" @default.
- W2014874657 creator A5001824833 @default.
- W2014874657 creator A5035748821 @default.
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- W2014874657 date "2013-08-01" @default.
- W2014874657 modified "2023-10-13" @default.
- W2014874657 title "Genome-wide identification of genes regulated in<i>trans</i>by transposable element small interfering RNAs" @default.
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- W2014874657 doi "https://doi.org/10.4161/rna.25555" @default.
- W2014874657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3817159" @default.
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