Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014875912> ?p ?o ?g. }
- W2014875912 abstract "Innate immunity and tissue proliferation play important roles in otitis media (OM), the most common disease of childhood. CJUN terminal kinase (JNK) is potentially involved in both processes.Genes involved in both innate immune and growth factor activation of JNK are upregulated during OM, while expression of both positive and negative JNK regulatory genes is altered. When compared to wildtypes (WTs), C57BL/6 mice deficient in JNK1 exhibit enhanced mucosal thickening, with delayed recovery, enhanced neutrophil recruitment early in OM, and delayed bacterial clearance. In contrast, JNK2-/- mice exhibit delayed mucosal hyperplasia that eventually exceeds that of WTs and is slow to recover, delayed recruitment of neutrophils, and failure of bacterial clearance.The results suggest that JNK1 and JNK2 play primarily opposing roles in mucosal hyperplasia and neutrophil recruitment early in OM. However, both isoforms are required for the normal resolution of middle ear infection." @default.
- W2014875912 created "2016-06-24" @default.
- W2014875912 creator A5010031854 @default.
- W2014875912 creator A5013796910 @default.
- W2014875912 creator A5022129072 @default.
- W2014875912 creator A5037947412 @default.
- W2014875912 creator A5061529952 @default.
- W2014875912 creator A5087223772 @default.
- W2014875912 creator A5087735390 @default.
- W2014875912 date "2014-10-14" @default.
- W2014875912 modified "2023-10-09" @default.
- W2014875912 title "C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media" @default.
- W2014875912 cites W1572174728 @default.
- W2014875912 cites W1706533503 @default.
- W2014875912 cites W1966112891 @default.
- W2014875912 cites W1971925780 @default.
- W2014875912 cites W1976083854 @default.
- W2014875912 cites W1986974750 @default.
- W2014875912 cites W1994219871 @default.
- W2014875912 cites W1997110892 @default.
- W2014875912 cites W2001617515 @default.
- W2014875912 cites W2011760895 @default.
- W2014875912 cites W2016035376 @default.
- W2014875912 cites W2026756845 @default.
- W2014875912 cites W2036224418 @default.
- W2014875912 cites W2036662476 @default.
- W2014875912 cites W2042376897 @default.
- W2014875912 cites W2052071148 @default.
- W2014875912 cites W2056221908 @default.
- W2014875912 cites W2058744360 @default.
- W2014875912 cites W2076485183 @default.
- W2014875912 cites W2076515532 @default.
- W2014875912 cites W2079712059 @default.
- W2014875912 cites W2088863984 @default.
- W2014875912 cites W2089580797 @default.
- W2014875912 cites W2095591126 @default.
- W2014875912 cites W2096264631 @default.
- W2014875912 cites W2104146721 @default.
- W2014875912 cites W2109709409 @default.
- W2014875912 cites W2109978703 @default.
- W2014875912 cites W2126081240 @default.
- W2014875912 cites W2132994355 @default.
- W2014875912 cites W2143516276 @default.
- W2014875912 cites W2144517045 @default.
- W2014875912 cites W2145965566 @default.
- W2014875912 cites W2155280531 @default.
- W2014875912 cites W2163373413 @default.
- W2014875912 cites W2166556795 @default.
- W2014875912 cites W2166947044 @default.
- W2014875912 cites W2169906167 @default.
- W2014875912 cites W4294316044 @default.
- W2014875912 doi "https://doi.org/10.1186/s12865-014-0046-z" @default.
- W2014875912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4200133" @default.
- W2014875912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25311344" @default.
- W2014875912 hasPublicationYear "2014" @default.
- W2014875912 type Work @default.
- W2014875912 sameAs 2014875912 @default.
- W2014875912 citedByCount "15" @default.
- W2014875912 countsByYear W20148759122016 @default.
- W2014875912 countsByYear W20148759122017 @default.
- W2014875912 countsByYear W20148759122018 @default.
- W2014875912 countsByYear W20148759122019 @default.
- W2014875912 countsByYear W20148759122020 @default.
- W2014875912 countsByYear W20148759122021 @default.
- W2014875912 countsByYear W20148759122022 @default.
- W2014875912 crossrefType "journal-article" @default.
- W2014875912 hasAuthorship W2014875912A5010031854 @default.
- W2014875912 hasAuthorship W2014875912A5013796910 @default.
- W2014875912 hasAuthorship W2014875912A5022129072 @default.
- W2014875912 hasAuthorship W2014875912A5037947412 @default.
- W2014875912 hasAuthorship W2014875912A5061529952 @default.
- W2014875912 hasAuthorship W2014875912A5087223772 @default.
- W2014875912 hasAuthorship W2014875912A5087735390 @default.
- W2014875912 hasBestOaLocation W20148759121 @default.
- W2014875912 hasConcept C104317684 @default.
- W2014875912 hasConcept C127561419 @default.
- W2014875912 hasConcept C136449434 @default.
- W2014875912 hasConcept C184235292 @default.
- W2014875912 hasConcept C203014093 @default.
- W2014875912 hasConcept C2776439223 @default.
- W2014875912 hasConcept C53345823 @default.
- W2014875912 hasConcept C54355233 @default.
- W2014875912 hasConcept C86803240 @default.
- W2014875912 hasConcept C8891405 @default.
- W2014875912 hasConcept C95444343 @default.
- W2014875912 hasConceptScore W2014875912C104317684 @default.
- W2014875912 hasConceptScore W2014875912C127561419 @default.
- W2014875912 hasConceptScore W2014875912C136449434 @default.
- W2014875912 hasConceptScore W2014875912C184235292 @default.
- W2014875912 hasConceptScore W2014875912C203014093 @default.
- W2014875912 hasConceptScore W2014875912C2776439223 @default.
- W2014875912 hasConceptScore W2014875912C53345823 @default.
- W2014875912 hasConceptScore W2014875912C54355233 @default.
- W2014875912 hasConceptScore W2014875912C86803240 @default.
- W2014875912 hasConceptScore W2014875912C8891405 @default.
- W2014875912 hasConceptScore W2014875912C95444343 @default.
- W2014875912 hasIssue "1" @default.
- W2014875912 hasLocation W20148759121 @default.
- W2014875912 hasLocation W20148759122 @default.
- W2014875912 hasLocation W20148759123 @default.