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- W2014876036 abstract "Abstract A rat open field test is described in which the inherent tendency of rats to explore an environment is titrated against their inherent tendency to avoid an open field that is large, brightly illuminated, ceilingless, and novel. The procedure appeared responsive to the effects of benzodiazepines, barbiturates, and some related compounds. Particularly pronounced activity was obtained with ritanserin; the compound disinhibited rat exploratory behavior at doses ranging from 0.04 to 10 mg/kg. Ritanserin, but not chlordiazepoxide, significantly increased the number of animals entering the open field. Chlordiazepoxide, but not ritanserin, significantly increased the number of animals making at least nine transits. The observations suggest that chlordiazepoxide and ritanserin differ in their mode of disinhibitory action on rat open field behavior." @default.
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- W2014876036 title "A comparative study of the effects of ritanserin (R 55 667) and chlordiazepoxide on rat open field behavior" @default.
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- W2014876036 doi "https://doi.org/10.1002/ddr.430080123" @default.
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