Matches in SemOpenAlex for { <https://semopenalex.org/work/W2014881738> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2014881738 endingPage "328" @default.
- W2014881738 startingPage "324" @default.
- W2014881738 abstract "<i>Background:</i> The vascular deposition of amyloid known as cerebral amyloid angiopathy (CAA) – an age-associated condition and a common finding in Alzheimer’s disease – compromises cerebral blood flow, causing macro/microhemorrhages and/or cognitive impairment. Very little is known about the mechanisms causing CAA-related degeneration of cerebral vascular cells. The Dutch E22Q familial amyloid-β (Aβ) variant is primarily associated with CAA, and manifests clinically with severe cerebral hemorrhages. <i>Objective:</i> We aimed to determine the molecular mechanisms causing apoptosis of cerebral endothelial cells in the presence of wild-type Aβ40 or its vasculotropic E22Q variant. <i>Methods:</i> We challenged human brain microvascular endothelial cells with both Aβ variants, and studied the apoptotic pathways triggered by these peptides. <i>Results:</i> Caspase-mediated apoptotic pathways were elicited by both peptides within time frames correlating with their aggregation properties and formation of oligomeric/protofibrillar assemblies. Our data revealed a primary activation of caspase-8 (typically triggered by death receptors) with secondary engagement of caspase-9, with cytochrome C and apoptosis-inducing factor release from the mitochondria, suggesting the independent or synergistic engagement of extrinsic and intrinsic apoptotic mechanisms. <i>Conclusion: </i>Our data demonstrate the induction of caspase-8- and caspase-9-dependent mitochondrial-mediated apoptotic pathways by Aβ oligomers/protofibrils in vascular cells, likely implicating a primary activation of death receptors." @default.
- W2014881738 created "2016-06-24" @default.
- W2014881738 creator A5000453166 @default.
- W2014881738 creator A5031100058 @default.
- W2014881738 creator A5081547926 @default.
- W2014881738 date "2011-12-07" @default.
- W2014881738 modified "2023-10-18" @default.
- W2014881738 title "Insights into Caspase-Mediated Apoptotic Pathways Induced by Amyloid-β in Cerebral Microvascular Endothelial Cells" @default.
- W2014881738 cites W1600652270 @default.
- W2014881738 cites W1981458288 @default.
- W2014881738 cites W1992758695 @default.
- W2014881738 cites W2015640782 @default.
- W2014881738 cites W2063272219 @default.
- W2014881738 cites W2081598046 @default.
- W2014881738 cites W2093910429 @default.
- W2014881738 cites W2107798346 @default.
- W2014881738 doi "https://doi.org/10.1159/000332821" @default.
- W2014881738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3363348" @default.
- W2014881738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22156599" @default.
- W2014881738 hasPublicationYear "2011" @default.
- W2014881738 type Work @default.
- W2014881738 sameAs 2014881738 @default.
- W2014881738 citedByCount "35" @default.
- W2014881738 countsByYear W20148817382012 @default.
- W2014881738 countsByYear W20148817382013 @default.
- W2014881738 countsByYear W20148817382014 @default.
- W2014881738 countsByYear W20148817382015 @default.
- W2014881738 countsByYear W20148817382016 @default.
- W2014881738 countsByYear W20148817382017 @default.
- W2014881738 countsByYear W20148817382018 @default.
- W2014881738 countsByYear W20148817382019 @default.
- W2014881738 countsByYear W20148817382020 @default.
- W2014881738 countsByYear W20148817382021 @default.
- W2014881738 countsByYear W20148817382022 @default.
- W2014881738 countsByYear W20148817382023 @default.
- W2014881738 crossrefType "journal-article" @default.
- W2014881738 hasAuthorship W2014881738A5000453166 @default.
- W2014881738 hasAuthorship W2014881738A5031100058 @default.
- W2014881738 hasAuthorship W2014881738A5081547926 @default.
- W2014881738 hasBestOaLocation W20148817381 @default.
- W2014881738 hasConcept C12519072 @default.
- W2014881738 hasConcept C142724271 @default.
- W2014881738 hasConcept C170493617 @default.
- W2014881738 hasConcept C185592680 @default.
- W2014881738 hasConcept C190283241 @default.
- W2014881738 hasConcept C2777790613 @default.
- W2014881738 hasConcept C2779134260 @default.
- W2014881738 hasConcept C2779483572 @default.
- W2014881738 hasConcept C28859421 @default.
- W2014881738 hasConcept C29311851 @default.
- W2014881738 hasConcept C31573885 @default.
- W2014881738 hasConcept C502032728 @default.
- W2014881738 hasConcept C502942594 @default.
- W2014881738 hasConcept C55493867 @default.
- W2014881738 hasConcept C71924100 @default.
- W2014881738 hasConcept C86803240 @default.
- W2014881738 hasConcept C95444343 @default.
- W2014881738 hasConcept C98424977 @default.
- W2014881738 hasConceptScore W2014881738C12519072 @default.
- W2014881738 hasConceptScore W2014881738C142724271 @default.
- W2014881738 hasConceptScore W2014881738C170493617 @default.
- W2014881738 hasConceptScore W2014881738C185592680 @default.
- W2014881738 hasConceptScore W2014881738C190283241 @default.
- W2014881738 hasConceptScore W2014881738C2777790613 @default.
- W2014881738 hasConceptScore W2014881738C2779134260 @default.
- W2014881738 hasConceptScore W2014881738C2779483572 @default.
- W2014881738 hasConceptScore W2014881738C28859421 @default.
- W2014881738 hasConceptScore W2014881738C29311851 @default.
- W2014881738 hasConceptScore W2014881738C31573885 @default.
- W2014881738 hasConceptScore W2014881738C502032728 @default.
- W2014881738 hasConceptScore W2014881738C502942594 @default.
- W2014881738 hasConceptScore W2014881738C55493867 @default.
- W2014881738 hasConceptScore W2014881738C71924100 @default.
- W2014881738 hasConceptScore W2014881738C86803240 @default.
- W2014881738 hasConceptScore W2014881738C95444343 @default.
- W2014881738 hasConceptScore W2014881738C98424977 @default.
- W2014881738 hasIssue "1-4" @default.
- W2014881738 hasLocation W20148817381 @default.
- W2014881738 hasLocation W20148817382 @default.
- W2014881738 hasLocation W20148817383 @default.
- W2014881738 hasLocation W20148817384 @default.
- W2014881738 hasOpenAccess W2014881738 @default.
- W2014881738 hasPrimaryLocation W20148817381 @default.
- W2014881738 hasRelatedWork W1831945918 @default.
- W2014881738 hasRelatedWork W1971518346 @default.
- W2014881738 hasRelatedWork W1977329581 @default.
- W2014881738 hasRelatedWork W2050266038 @default.
- W2014881738 hasRelatedWork W2058000280 @default.
- W2014881738 hasRelatedWork W2111512232 @default.
- W2014881738 hasRelatedWork W2136043745 @default.
- W2014881738 hasRelatedWork W2157999078 @default.
- W2014881738 hasRelatedWork W2219970926 @default.
- W2014881738 hasRelatedWork W2423395710 @default.
- W2014881738 hasVolume "10" @default.
- W2014881738 isParatext "false" @default.
- W2014881738 isRetracted "false" @default.
- W2014881738 magId "2014881738" @default.
- W2014881738 workType "article" @default.